Brewers vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 9:12 p.m.

The Milwaukee Brewers and the Chicago White Sox meet for MLB Opening Day on Thursday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs White Sox Game Info

• Milwaukee Brewers (0-0) vs. Chicago White Sox (0-0)
• Date: Thursday, March 26, 2026
• Time: 2:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: BREW and CHSN

Brewers vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-184) | CHW: (+154)
• Spread: MIL: -1.5 (+114) | CHW: +1.5 (-137)
• Total: 8 -- Over: (-105) | Under: (-115)

Brewers vs White Sox Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 0-0, 0.00 ERA vs Shane Smith (White Sox) - 0-0, 0.00 ERA

The Brewers will look to Jacob Misiorowski versus the White Sox and Shane Smith. Misiorowski and his team were 8-6-0 ATS in games he pitched last year. Misiorowski and his team won 50% of the games he started as the moneyline favorite last season, with a record of 4-4. Last season Smith and his team went 17-12-0 against the spread in games he pitched. Smith and his team went 9-17 in games he appeared in when they were the moneyline underdog a season ago.

Brewers vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (68.9%)

Brewers vs White Sox Moneyline

• Chicago is a +154 underdog on the moneyline, while Milwaukee is a -184 favorite at home.

Brewers vs White Sox Spread

• The White Sox are +1.5 on the run line against the Brewers. The White Sox are -137 to cover, and the Brewers are +114.

Brewers vs White Sox Over/Under

• The over/under for Brewers-White Sox on March 26 is 8. The over is -105, and the under is -115.

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Brewers vs White Sox Betting Trends

• The Brewers were favorites in 100 games last season and came away with the win 63 times (63%) in those contests.
• Last year, Milwaukee won 17 of 20 games when listed as at least -184 on the moneyline.
• The Brewers and their opponents hit the over in 82 of their 168 games with a total last season.
• The White Sox were the moneyline underdog 153 times last season. They went 56-97 in those games.
• Chicago went 18-47 in games it played as a moneyline underdog with odds of +154 or longer (27.7%).
• The White Sox played in 157 games with an over/under set last season, and combined with their opponents to go over the total 72 times (72-77-8).

Brewers Player Leaders

• Brice Turang finished with an OPS of .794 last season, fueled by a .359 OBP and a slugging percentage of .435.
• Christian Yelich slashed .264/.343/.452 and finished with an OPS of .795.
• Last season, William Contreras finished with 17 home runs, 76 RBI and a batting average of .260 last season.
• Jackson Chourio had 148 hits while batting .270 with 60 extra-base hits.

White Sox Player Leaders

• Miguel Vargas had 32 doubles, two triples, 16 home runs and 56 walks while batting .234 last season.
• Andrew Benintendi hit .240 with 16 doubles, two triples, 20 home runs and 40 walks.
• Lenyn Sosa had a slugging percentage of .434 while collecting 137 hits a season ago.
• Austin Hays hit .266 with 16 doubles, five triples, 15 home runs and 29 walks.

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