Brewers vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 1:12 p.m.

MLB Opening Day on Thursday features the Milwaukee Brewers facing the Chicago White Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Brewers vs White Sox Game Info

• Milwaukee Brewers (0-0) vs. Chicago White Sox (0-0)
• Date: Thursday, March 26, 2026
• Time: 2:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and CHSN

Brewers vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-184) | CHW: (+154)
• Spread: MIL: -1.5 (+116) | CHW: +1.5 (-140)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Brewers vs White Sox Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 0-0, 0.00 ERA vs Shane Smith (White Sox) - 0-0, 0.00 ERA

The Brewers will look to Jacob Misiorowski against the White Sox and Shane Smith. Misiorowski and his team were 8-6-0 ATS in games he pitched last year. Misiorowski and his team won as favorites in 50% of his eight appearances last season with a moneyline. Last season Smith and his team had a 17-12-0 record against the spread when he pitched. Smith and his team went 9-17 in games he appeared in when they were the moneyline underdog a season ago.

Brewers vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (66.6%)

Brewers vs White Sox Moneyline

• Milwaukee is the favorite, -184 on the moneyline, while Chicago is a +154 underdog on the road.

Brewers vs White Sox Spread

• The Brewers are favored by 1.5 runs at home versus the White Sox. The Brewers are +116 to cover the spread, while the White Sox are -140.

Brewers vs White Sox Over/Under

• Brewers versus White Sox, on March 26, has an over/under of 7.5, with the over being -122 and the under +100.

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Brewers vs White Sox Betting Trends

• The Brewers came away with 63 wins in the 100 contests they were listed as the favorites last season.
• Last year, Milwaukee won 17 of 20 games when listed as at least -184 on the moneyline.
• The Brewers and their opponents hit the over in 82 of their 168 games with a total last season.
• The White Sox finished 56-97 in games they were listed as the moneyline underdog last season (winning 36.6% of those games).
• In games it played as a moneyline underdog with odds of +154 or longer last year, Chicago went 18-47 (27.7%).
• The White Sox combined with their opponents to hit the over on the total 72 times last season for a 72-77-8 record against the over/under.

Brewers Player Leaders

• Brice Turang had an OBP of .359 to go with a slugging percentage of .435 last season.
• Christian Yelich slashed .264/.343/.452 and finished with an OPS of .795.
• Last season, William Contreras finished with 17 home runs, 76 RBI and a batting average of .260 last season.
• Jackson Chourio slashed .270/.308/.463 and finished with an OPS of .770.

White Sox Player Leaders

• Miguel Vargas hit .234 with 32 doubles, two triples, 16 home runs and 56 walks a season ago.
• Andrew Benintendi hit .240 with 16 doubles, two triples, 20 home runs and 40 walks.
• Lenyn Sosa had 137 hits with a .434 slugging percentage last season.
• Austin Hays hit .266 with 16 doubles, five triples, 15 home runs and 29 walks.

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