Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 1:12 p.m.

Friday's slate in the MLB includes a matchup between the Milwaukee Brewers and the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Pirates Game Info

• Milwaukee Brewers (86-55) vs. Pittsburgh Pirates (64-77)
• Date: Friday, September 5, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-142) | PIT: (+120)
• Spread: MIL: -1.5 (+118) | PIT: +1.5 (-142)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Quinn Priester (Brewers) - 11-2, 3.28 ERA vs Johan Oviedo (Pirates) - 2-0, 3.60 ERA

The Brewers will give the nod to Quinn Priester (11-2) against the Pirates and Johan Oviedo (2-0). Priester and his team are 12-8-0 ATS this season when he starts. Priester's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. The Pirates covered in each of the four games Oviedo started that had a spread set by bookmakers. The Pirates have a 3-1 record in Oviedo's four starts this season when they were the moneyline underdog.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.7%)

Brewers vs Pirates Moneyline

• Milwaukee is the favorite, -142 on the moneyline, while Pittsburgh is a +120 underdog despite being at home.

Brewers vs Pirates Spread

• The Brewers are favored by 1.5 runs on the road versus the Pirates. The Brewers are +118 to cover the spread, while the Pirates are -142.

Brewers vs Pirates Over/Under

• An over/under of 8.5 has been set for Brewers-Pirates on Sept. 5, with the over being -108 and the under -112.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have won in 50, or 64.9%, of the 77 contests they have been named as odds-on favorites in this year.
• This season Milwaukee has been victorious 28 times in 39 chances when named as a favorite of at least -142 on the moneyline.
• The Brewers' games have gone over the total in 69 of their 138 opportunities.
• The Brewers have an against the spread mark of 78-60-0 in 138 games with a line this season.
• The Pirates have been the moneyline underdog 93 total times this season. They've finished 41-52 in those games.
• When it has played as a moneyline underdog with odds of +120 or longer, Pittsburgh has gone 23-38 (37.7%).
• The Pirates have played in 133 games with a set over/under, and have combined with their opponents to go over the total 53 times (53-74-6).
• The Pirates have a 74-59-0 record against the spread this season.

Brewers Player Leaders

• William Contreras is hitting .261 with 26 doubles, 17 home runs and 77 walks. He has an on-base percentage of .357 while slugging .411.
• Among qualified hitters in MLB, his batting average ranks 73rd, his on-base percentage ranks 28th, and he is 91st in slugging.
• Contreras has hit safely in four games in a row. In his last five games he is batting .300 with a double, a home run, two walks and three RBIs.
• Brice Turang leads Milwaukee in slugging percentage (.449) thanks to 44 extra-base hits. He's batting .291 with an on-base percentage of .358.
• His batting average is 15th among qualified players, his on-base percentage 25th, and his slugging percentage 62nd.
• Christian Yelich has collected 134 base hits, an OBP of .350 and a slugging percentage of .464 this season.
• Jackson Chourio leads Milwaukee with 129 hits, batting .279 this season with 53 extra-base hits.

Pirates Player Leaders

• Bryan Reynolds has accumulated 127 hits with a .411 slugging percentage, both team-best figures for the Pirates. He's batting .246 and with an on-base percentage of .313.
• Including all qualified hitters in the big leagues, he is 108th in batting average, 113th in on-base percentage and 91st in slugging percentage.
• Oneil Cruz is hitting .202 with 17 doubles, two triples, 19 home runs and 59 walks. He's slugging .389 with an on-base percentage of .304.
• He is 152nd in batting average, 126th in on-base percentage and 122nd in slugging percentage in the majors.
• Andrew McCutchen a has .342 on-base percentage to lead the Pirates.
• Tommy Pham is batting .264 with 16 doubles, a triple, eight home runs and 39 walks.

Brewers vs Pirates Head to Head

• 8/13/2025: 12-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/12/2025: 14-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/11/2025: 7-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2025: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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