Blue Jays vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 12:12 p.m.

The San Diego Padres are among the MLB teams playing on Thursday, versus the Toronto Blue Jays.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Padres vs Blue Jays Game Info

• San Diego Padres (27-20) vs. Toronto Blue Jays (24-24)
• Date: Thursday, May 22, 2025
• Time: 1:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: MLB Network, SNET, and SDPA

Padres vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | TOR: (-102)
• Spread: SD: -1.5 (+140) | TOR: +1.5 (-170)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Padres vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Stephen Kolek (Padres) - 2-1, 2.33 ERA vs Bowden Francis (Blue Jays) - 2-6, 5.63 ERA

The Padres will give the nod to Stephen Kolek (2-1, 2.33 ERA), who is eyeing win No. 3 on the season, and the Blue Jays will turn to Bowden Francis (2-6, 5.63 ERA). Kolek and his team are 2-1-0 ATS this season when he starts. Kolek's team is 1-1 this season when he starts and they're favored on the moneyline. The Blue Jays are 7-2-0 ATS in Francis' nine starts with a set spread. The Blue Jays have a 1-6 record in Francis' seven starts this season when they were the moneyline underdog.

Padres vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (55.1%)

Padres vs Blue Jays Moneyline

• The Padres vs Blue Jays moneyline has San Diego as a -116 favorite, while Toronto is a -102 underdog at home.

Padres vs Blue Jays Spread

• The Padres are favored by 1.5 runs on the road versus the Blue Jays. The Padres are +140 to cover the spread, while the Blue Jays are -170.

Padres vs Blue Jays Over/Under

• A combined run total of 8.5 has been set for Padres-Blue Jays on May 22, with the over at -122 and the under at -100.

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Padres vs Blue Jays Betting Trends

• The Padres have been victorious in 16, or 64%, of the 25 contests they have been chosen as favorites in this season.
• This season San Diego has been victorious 16 times in 25 chances when named as a favorite of at least -116 on the moneyline.
• The Padres and their opponents have gone over the total this season in 20 of their 46 opportunities.
• In 46 games with a line this season, the Padres have a mark of 25-21-0 against the spread.
• The Blue Jays have compiled a 14-14 record in games they were the underdog on the moneyline (winning 50% of those games).
• When playing as a moneyline underdog with odds of -102 or longer, Toronto has a 10-11 record (winning 47.6% of its games).
• The Blue Jays have played in 47 games with a set over/under, and have combined with their opponents to go over the total 24 times (24-22-1).
• The Blue Jays have covered 63.8% of their games this season, going 30-17-0 against the spread.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in total hits (53) this season while batting .296 with 19 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .542.
• Among the qualifying hitters in the majors, his batting average ranks 24th, his on-base percentage ranks 37th, and he is 12th in slugging.
• Manny Machado is slashing .314/.383/.453 this season and leads the Padres with an OPS of .837.
• He is ninth in batting average, 17th in on-base percentage and 56th in slugging in the major leagues.
• Luis Arraez is batting .301 with a .434 slugging percentage and 15 RBI this year.
• Arraez has picked up a hit in eight straight games. In his last 10 outings he is batting .333 with three doubles, two triples, a walk and three RBIs.
• Xander Bogaerts has been key for San Diego with 39 hits, an OBP of .330 plus a slugging percentage of .354.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. a has .389 on-base percentage to pace the Blue Jays. He's batting .287 while slugging .433.
• Including all the qualifying players in the big leagues, his batting average is 33rd, his on-base percentage ranks 15th, and he is 70th in slugging.
• Guerrero hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .222 with a home run, three walks and two RBIs.
• Bo Bichette's .420 slugging percentage paces his team. He has a batting average of .288 with an on-base percentage of .335.
• Including all qualified hitters, he is 30th in batting average, 72nd in on-base percentage and 79th in slugging percentage.
• George Springer leads the Blue Jays with 38 hits.
• Alejandro Kirk has four doubles, three home runs and seven walks while batting .277.

Padres vs Blue Jays Head to Head

• 5/21/2025: 14-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/20/2025: 3-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/21/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2024: 5-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/19/2024: 5-1 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/20/2023: 4-0 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2023: 2-0 SD (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/18/2023: 9-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)

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