Blue Jays vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 12:12 a.m.

The MLB's Thursday schedule includes the San Diego Padres taking on the Toronto Blue Jays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Padres vs Blue Jays Game Info

• San Diego Padres (27-20) vs. Toronto Blue Jays (24-24)
• Date: Thursday, May 22, 2025
• Time: 1:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: MLB Network, SNET, and SDPA

Padres vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-112) | TOR: (-104)
• Spread: SD: -1.5 (+138) | TOR: +1.5 (-166)
• Total: 9 -- Over: (-108) | Under: (-112)

Padres vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Stephen Kolek (Padres) - 2-1, 2.33 ERA vs Bowden Francis (Blue Jays) - 2-6, 5.63 ERA

The Padres will give the nod to Stephen Kolek (2-1, 2.33 ERA), who is eyeing win No. 3 on the season, and the Blue Jays will counter with Bowden Francis (2-6, 5.63 ERA). When Kolek starts, his team is 2-1-0 against the spread this season. Kolek's team is 1-1 this season when he starts and they're favored on the moneyline. When Francis starts, the Blue Jays are 7-2-0 against the spread. The Blue Jays have been the underdog on the moneyline in seven of Francis' starts this season, and they went 1-6 in those games.

Padres vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.6%)

Padres vs Blue Jays Moneyline

• Looking at the moneyline for Padres-Blue Jays, San Diego is the favorite at -112, and Toronto is -104 playing at home.

Padres vs Blue Jays Spread

• The Padres are favored by 1.5 runs on the road against the Blue Jays. The Padres are +138 to cover the spread, while the Blue Jays are -166.

Padres vs Blue Jays Over/Under

• The Padres-Blue Jays game on May 22 has been given an over/under of 9 runs. The over is set at -108 and the under at -112.

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Padres vs Blue Jays Betting Trends

• The Padres have won in 16, or 64%, of the 25 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win 16 times in 25 chances when named as a favorite of at least -112 on the moneyline.
• The Padres and their opponents have gone over the total this season in 20 of their 46 opportunities.
• The Padres are 25-21-0 against the spread in their 46 games that had a posted line this season.
• The Blue Jays are 14-14 in games they were the underdog on the moneyline (winning 50% of those games).
• Toronto is 11-13 (winning 45.8% of its games) when playing as a moneyline underdog of -104 or longer.
• The Blue Jays have played in 47 games with an over/under set, and have combined with opponents to go over the total 24 times (24-22-1).
• The Blue Jays have gone 30-17-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 53 hits, batting .296 this season with 19 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .542.
• Among all qualifying hitters in the majors, he ranks 24th in batting average, 37th in on-base percentage, and 12th in slugging.
• Manny Machado has a slash line of .314/.383/.453 this season and a team-best OPS of .837.
• He is ninth in batting average, 17th in on-base percentage and 57th in slugging among qualified hitters.
• Luis Arraez has collected 50 base hits, an OBP of .337 and a slugging percentage of .434 this season.
• Arraez has recorded a hit in eight straight games. During his last 10 games he is batting .333 with three doubles, two triples, a walk and three RBIs.
• Xander Bogaerts has been key for San Diego with 39 hits, an OBP of .330 plus a slugging percentage of .354.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has racked up an on-base percentage of .389, a team-high for the Blue Jays. He's batting .287 and slugging .433.
• Including all the qualifying hitters in MLB, he ranks 33rd in batting average, 15th in on-base percentage and 72nd in slugging percentage.
• Guerrero enters this game on a three-game hitting streak. During his last five outings he is hitting .222 with a home run, three walks and two RBIs.
• Bo Bichette paces his team with a .420 slugging percentage. He has a batting average of .288 with an on-base percentage of .335.
• Including all qualified players, he is 30th in batting average, 71st in on-base percentage and 79th in slugging percentage.
• George Springer paces the Blue Jays with 38 hits.
• Alejandro Kirk is hitting .277 with four doubles, three home runs and seven walks.

Padres vs Blue Jays Head to Head

• 5/21/2025: 14-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/20/2025: 3-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/21/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2024: 5-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/19/2024: 5-1 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/20/2023: 4-0 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2023: 2-0 SD (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/18/2023: 9-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)

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