Blue Jays vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 6:11 p.m.

MLB action on Wednesday includes the Toronto Blue Jays playing the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Padres Game Info

• Toronto Blue Jays (23-24) vs. San Diego Padres (27-19)
• Date: Wednesday, May 21, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SN1 and SDPA

Blue Jays vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-166) | SD: (+140)
• Spread: TOR: -1.5 (+118) | SD: +1.5 (-142)
• Total: 9 -- Over: (-100) | Under: (-122)

Blue Jays vs Padres Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 3-4, 4.59 ERA vs Randy Vasquez (Padres) - 3-3, 3.45 ERA

This contest's pitching matchup is set, as the Blue Jays will send Kevin Gausman (3-4) to the mound, while Randy Vasquez (3-3) will answer the bell for the Padres. Gausman and his team are 4-5-0 ATS this season when he starts. Gausman's team is 1-2 this season when he starts and they are the moneyline favorite. The Padres have a 5-3-0 record against the spread in Vasquez's starts. The Padres have been the moneyline underdog in six of Vasquez's starts this season, and they went 2-4 in those games.

Blue Jays vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.6%)

Blue Jays vs Padres Moneyline

• Looking at the moneyline for Blue Jays-Padres, Toronto is the favorite at -166, and San Diego is +140 playing on the road.

Blue Jays vs Padres Spread

• The Padres are +1.5 on the run line against the Blue Jays. The Padres are -142 to cover, and the Blue Jays are +118.

Blue Jays vs Padres Over/Under

• The over/under for the Blue Jays versus Padres contest on May 21 has been set at 9, with -100 odds on the over and -122 odds on the under.

Bet on Toronto Blue Jays vs. San Diego Padres on FanDuel today!

Blue Jays vs Padres Betting Trends

• The Blue Jays have been favorites in 17 games this season and have come away with the win eight times (47.1%) in those contests.
• Toronto has a record of 2-1 when favored by -166 or more this year.
• The Blue Jays' games have gone over the total in 23 of their 46 opportunities.
• The Blue Jays have an against the spread mark of 29-17-0 in 46 games with a line this season.
• The Padres have won 47.1% of the games this season they were the moneyline underdog (8-9).
• San Diego has played as a moneyline underdog of +140 or longer in only two games this season, which it lost both.
• The Padres have had an over/under set by bookmakers 45 times, and have combined with opponents to go over the total in 19 of those games (19-25-1).
• The Padres have a 25-20-0 record ATS this season (covering 55.6% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has 50 hits this season and a team-best OBP of .393. He has a .289 batting average and a slugging percentage of .439.
• Among qualifying batters, he is 30th in batting average, his on-base percentage ranks 11th, and he is 65th in slugging.
• Guerrero hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .267 with two home runs, five walks and two RBIs.
• Bo Bichette leads Toronto in slugging percentage (.422) thanks to 19 extra-base hits. He's batting .286 with an on-base percentage of .335.
• His batting average is 35th among qualified players, his on-base percentage 70th, and his slugging percentage 76th.
• George Springer leads Toronto in total hits (36) this season, and 16 of those have gone for extra bases.
• Alejandro Kirk is batting .283 with a .310 OBP and 18 RBI for Toronto this season.

Padres Player Leaders

• Fernando Tatis Jr. has put up a team-high slugging percentage (.554) while pacing the Padres in hits (53). He's batting .303 and with an on-base percentage of .372.
• Including all the qualified hitters in the majors, he ranks 19th in batting average, 30th in on-base percentage and 10th in slugging percentage.
• Tatis brings a four-game hitting streak into this game. During his last five outings he is batting .200 with a double, a home run, a walk and an RBI.
• Manny Machado has a .381 OBP to lead his team. He has a batting average of .310 while slugging .446.
• Including all qualified players, he ranks ninth in batting average, 18th in on-base percentage and 60th in slugging percentage.
• Luis Arraez is batting .296 with six doubles, two triples, three home runs and nine walks.
• Xander Bogaerts is hitting .247 with nine doubles, three home runs and 22 walks.

Blue Jays vs Padres Head to Head

• 5/20/2025: 3-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/21/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2024: 5-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/19/2024: 5-1 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/20/2023: 4-0 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2023: 2-0 SD (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/18/2023: 9-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)

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