Blue Jays vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 6:12 a.m.

The Toronto Blue Jays are among the MLB teams in action on Wednesday, versus the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Padres Game Info

• Toronto Blue Jays (23-24) vs. San Diego Padres (27-19)
• Date: Wednesday, May 21, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SN1 and SDPA

Blue Jays vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-148) | SD: (+126)
• Spread: TOR: -1.5 (+130) | SD: +1.5 (-156)
• Total: 9 -- Over: (-100) | Under: (-122)

Blue Jays vs Padres Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 3-4, 4.59 ERA vs Randy Vasquez (Padres) - 3-3, 3.45 ERA

This contest's pitching matchup is set, as the Blue Jays will send Kevin Gausman (3-4) to the mound, while Randy Vasquez (3-3) will answer the bell for the Padres. Gausman's team is 4-5-0 against the spread this season in his starts. When Gausman starts a game and his team is the favorite on the moneyline, they have a record of 1-2. The Padres have a 5-3-0 record against the spread in Vasquez's starts. The Padres have a 2-4 record in Vasquez's six starts this season when they were the moneyline underdog.

Blue Jays vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50.8%)

Blue Jays vs Padres Moneyline

• San Diego is a +126 underdog on the moneyline, while Toronto is a -148 favorite at home.

Blue Jays vs Padres Spread

• The Padres are +1.5 on the spread (-156 to cover), and Toronto is +130 to cover the runline.

Blue Jays vs Padres Over/Under

• Blue Jays versus Padres, on May 21, has an over/under of 9, with the over being -100 and the under -122.

Bet on Toronto Blue Jays vs. San Diego Padres on FanDuel today!

Blue Jays vs Padres Betting Trends

• The Blue Jays have been favorites in 17 games this season and have come away with the win eight times (47.1%) in those contests.
• Toronto has a record of 4-2 when favored by -148 or more this year.
• The Blue Jays and their opponents have gone over in 23 of their 46 games with a total set by sportsbooks this season.
• The Blue Jays are 29-17-0 against the spread in their 46 games that had a posted line this season.
• The Padres have gone 8-9 in games they were listed as the moneyline underdog (winning 47.1% of those games).
• In games it has played as a moneyline underdog with odds of +126 or longer, San Diego has a 1-5 record (winning only 16.7% of its games).
• The Padres have combined with opponents to go over the total 19 times this season for a 19-25-1 record against the over/under.
• The Padres have covered 55.6% of their games this season, going 25-20-0 against the spread.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .393 this season while batting .289 with 30 walks and 27 runs scored. He has a slugging percentage of .439.
• Among the qualifying hitters in the majors, his batting average ranks 31st, his on-base percentage ranks 11th, and he is 67th in slugging.
• Guerrero has hit safely in two straight games. During his last five outings he is batting .267 with two home runs, five walks and two RBIs.
• Bo Bichette has hit four homers this season while driving in 22 runs. He's batting .286 this season and slugging .422 with an on-base percentage of .335.
• Among qualifying hitters, his batting average ranks him 35th, his on-base percentage 71st, and his slugging percentage 78th.
• George Springer leads Toronto in total hits (36) this season, and 16 of those have gone for extra bases.
• Alejandro Kirk is batting .283 with a .310 OBP and 18 RBI for Toronto this season.

Padres Player Leaders

• Fernando Tatis Jr. has a team-best slugging percentage (.554) while leading the Padres in hits (53). He's batting .303 and with an on-base percentage of .372.
• Including all the qualifying players in MLB, his batting average ranks 18th, his on-base percentage ranks 32nd, and he is 11th in slugging.
• Tatis takes a four-game hitting streak into this game. During his last five outings he is hitting .200 with a double, a home run, a walk and an RBI.
• Manny Machado's .381 OBP leads his team. He has a batting average of .310 while slugging .446.
• Including all qualifying hitters, he is 10th in batting average, 19th in on-base percentage and 61st in slugging percentage.
• Luis Arraez is batting .296 with six doubles, two triples, three home runs and nine walks.
• Xander Bogaerts is batting .247 with nine doubles, three home runs and 22 walks.

Blue Jays vs Padres Head to Head

• 5/20/2025: 3-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/21/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2024: 5-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/19/2024: 5-1 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/20/2023: 4-0 TOR (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2023: 2-0 SD (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/18/2023: 9-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)

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