Astros vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 11

Odds updated as of 2:11 p.m.

The Houston Astros versus the Cincinnati Reds is on the MLB schedule for Sunday.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Reds Game Info

• Houston Astros (19-19) vs. Cincinnati Reds (20-21)
• Date: Sunday, May 11, 2025
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSOH

Astros vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | CIN: (+122)
• Spread: HOU: -1.5 (+140) | CIN: +1.5 (-170)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Astros vs Reds Probable Starting Pitchers

Probable Pitchers: Ronel Blanco (Astros) - 2-3, 4.98 ERA vs Chase Petty (Reds) - 0-1, 34.71 ERA

The probable pitchers are Ronel Blanco (2-3) for the Astros and Chase Petty (0-1) for the Reds. Blanco's team is 4-3-0 against the spread in his starts this season. When Blanco starts a game and his team is the favorite on the moneyline, they have a record of 2-1. Petty has started just one game with a set spread, which the Reds failed to cover. The Reds have not been a moneyline underdog when Petty starts this season.

Astros vs Reds Moneyline

• Houston is the favorite, -144 on the moneyline, while Cincinnati is a +122 underdog on the road.

Astros vs Reds Spread

• The Reds are at the Astros, and are +1.5 on the runline. The Reds are +140 to cover the spread, and the Astros are -170.

Astros vs Reds Over/Under

• Astros versus Reds, on May 11, has an over/under of 8.5, with the over being -106 and the under -114.

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Astros vs Reds Betting Trends

• The Astros have been victorious in 14, or 51.9%, of the 27 contests they have been chosen as favorites in this season.
• Houston has a record of 4-4 when favored by -144 or more this year.
• The Astros and their opponents have gone over in 17 of their 38 games with a total set by sportsbooks this season.
• The Astros have posted a record of 21-17-0 against the spread this season.
• The Reds have won 43.5% of the games this season they were the underdog on the moneyline (10-13).
• Cincinnati has a 3-5 record (winning just 37.5% of its games) when playing as a moneyline underdog of +122 or longer.
• The Reds have played in 40 games with an over/under set, and have combined with opponents to go over the total 18 times (18-21-1).
• The Reds have put together a 21-19-0 record against the spread this season (covering 52.5% of the time).

Astros Player Leaders

• Jeremy Pena has 42 hits to go with a slugging percentage of .438, both of which are best among Houston hitters this season. He has a .288 batting average and an on-base percentage of .344.
• Among qualified hitters in baseball, his batting average ranks 31st, his on-base percentage ranks 61st, and he is 61st in slugging.
• Pena hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .318 with two doubles, a home run and seven RBIs.
• Isaac Paredes leads Houston with an OBP of .373 this season while batting .263 with 22 walks and 16 runs scored. He's slugging .401.
• Among qualifying batters, he ranks 67th in batting average, 31st in on-base percentage and 90th in slugging percentage.
• Paredes takes a three-game streak with at least one hit into this contest. During his last five outings he is batting .353 with two doubles, five walks and three RBIs.
• Jose Altuve has 38 hits this season and has a slash line of .259/.308/.374.
• Jake Meyers has two home runs, 13 RBI and a batting average of .296 this season.
• Meyers enters this game on a 10-game hitting streak. In his last 10 games he is batting .400 with a double, a triple, two home runs, five walks and eight RBIs.

Reds Player Leaders

• TJ Friedl has a team-best .392 slugging percentage. He's batting .281 with an on-base percentage of .360.
• He ranks 41st in batting average, 44th in on-base percentage and 99th in slugging percentage among all qualified batters in the majors.
• Elly De La Cruz is batting .250 with five doubles, six home runs and 17 walks. He's slugging .394 with an on-base percentage of .328.
• His batting average is 84th among all qualified players, his on-base percentage ranks 84th, and he is 95th in slugging.
• Gavin Lux has a team-best OBP (.385), and paces the Reds in hits (37).
• Jose Trevino has nine doubles, three home runs and five walks while hitting .310.

Astros vs Reds Head to Head

• 5/10/2025: 13-9 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2025: 3-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/5/2024: 1-0 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 12-5 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/2/2024: 5-3 CIN (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/18/2023: 9-7 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/17/2023: 10-3 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/16/2023: 2-1 CIN (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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