Astros vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 11

Odds updated as of 1:12 a.m.

On Sunday in MLB, the Houston Astros are up against the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Reds Game Info

• Houston Astros (19-19) vs. Cincinnati Reds (20-21)
• Date: Sunday, May 11, 2025
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSOH

Astros vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-148) | CIN: (+126)
• Spread: HOU: -1.5 (+142) | CIN: +1.5 (-172)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Astros vs Reds Probable Starting Pitchers

Probable Pitchers: Ronel Blanco (Astros) - 2-3, 4.98 ERA vs Chase Petty (Reds) - 0-1, 34.71 ERA

The Astros will give the nod to Ronel Blanco (2-3, 4.98 ERA), who is eyeing win No. 3 on the season, and the Reds will counter with Chase Petty (0-1, 34.71 ERA). When Blanco starts, his team is 4-3-0 against the spread this season. Blanco's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. Petty has started only one game with a set spread, which the Reds failed to cover. The Reds have not been a moneyline underdog when Petty starts this season.

Astros vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.5%)

Astros vs Reds Moneyline

• Cincinnati is a +126 underdog on the moneyline, while Houston is a -148 favorite at home.

Astros vs Reds Spread

• The Astros are hosting the Reds and are favored by 1.5 runs on the spread. The Astros are +142 to cover the runline, with the Reds being -172.

Astros vs Reds Over/Under

• An over/under of 8.5 has been set for Astros-Reds on May 11, with the over being -115 and the under -105.

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Astros vs Reds Betting Trends

• The Astros have been victorious in 14, or 51.9%, of the 27 contests they have been chosen as favorites in this season.
• This year Houston has won four of eight games when listed as at least -148 on the moneyline.
• The Astros and their opponents have hit the over in 17 of their 38 games with a total set by oddsmakers this season.
• The Astros are 21-17-0 against the spread in their 38 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 23 total times this season. They've gone 10-13 in those games.
• When it has played as a moneyline underdog with odds of +126 or longer, Cincinnati has gone 3-3 (50%).
• The Reds have played in 40 games with a set over/under, and have combined with their opponents to go over the total 18 times (18-21-1).
• The Reds have a 21-19-0 record ATS this season (covering 52.5% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston with 42 hits and a team-best slugging percentage of .438. He's batting .288 with an on-base percentage of .344.
• Among all qualifying hitters in the majors, his batting average ranks 31st, his on-base percentage ranks 61st, and he is 61st in slugging.
• Pena will look for his fourth straight game with a hit in this contest. In his last five games he is hitting .318 with two doubles, a home run and seven RBIs.
• Isaac Paredes leads Houston in OBP (.373) this season, fueled by 36 hits. He's batting .263 while slugging .401.
• Among qualified hitters, he ranks 67th in batting average, 31st in on-base percentage and 90th in slugging percentage.
• Paredes enters this game looking to extend his three-game hit streak. In his last five games he is batting .353 with two doubles, five walks and three RBIs.
• Jose Altuve has 38 hits this season and has a slash line of .259/.308/.374.
• Jake Meyers has two home runs, 13 RBI and a batting average of .296 this season.
• Meyers takes a 10-game hitting streak into this game. In his last 10 outings he is hitting .400 with a double, a triple, two home runs, five walks and eight RBIs.

Reds Player Leaders

• TJ Friedl has a slugging percentage of .392, a team-high for the Reds. He's batting .281 with an on-base percentage of .360.
• Including all qualified hitters in the majors, his batting average places him 41st, his on-base percentage is 44th, and he is 99th in slugging.
• Elly De La Cruz is batting .250 with five doubles, six home runs and 17 walks. He's slugging .394 with an on-base percentage of .328.
• He ranks 84th in batting average, 84th in on-base percentage and 95th in slugging percentage in the majors.
• Gavin Lux has racked up 37 hits with a .385 on-base percentage, leading the Reds in both categories.
• Jose Trevino is batting .310 with nine doubles, three home runs and five walks.

Astros vs Reds Head to Head

• 5/10/2025: 13-9 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2025: 3-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/5/2024: 1-0 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 12-5 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/2/2024: 5-3 CIN (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/18/2023: 9-7 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/17/2023: 10-3 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/16/2023: 2-1 CIN (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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