Astros vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 13

Odds updated as of 4:16 a.m.

Wednesday's slate in the MLB includes a matchup between the Houston Astros and the Boston Red Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Red Sox Game Info

• Houston Astros (67-53) vs. Boston Red Sox (66-55)
• Date: Wednesday, August 13, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NESN

Astros vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-174) | BOS: (+146)
• Spread: HOU: -1.5 (+122) | BOS: +1.5 (-146)
• Total: 8 -- Over: (-105) | Under: (-115)

Astros vs Red Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 9-5, 2.51 ERA vs Walker Buehler (Red Sox) - 7-6, 5.40 ERA

The probable pitchers are Hunter Brown (9-5) for the Astros and Walker Buehler (7-6) for the Red Sox. Brown's team is 13-10-0 against the spread in his starts this season. When Brown starts a game and his team is the favorite on the moneyline, they have a record of 11-7. The Red Sox are 12-8-0 against the spread when Buehler starts. The Red Sox have been the underdog on the moneyline in nine of Buehler's starts this season, and they went 4-5 in those matchups.

Astros vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (65%)

Astros vs Red Sox Moneyline

• Looking at the moneyline for Red Sox-Astros, Boston is the underdog at +146, and Houston is -174 playing at home.

Astros vs Red Sox Spread

• The Red Sox are at the Astros, and are +1.5 on the runline. The Red Sox are +122 to cover the spread, and the Astros are -146.

Astros vs Red Sox Over/Under

• Astros versus Red Sox on Aug. 13 has an over/under of 8 runs, with the odds on the over -105 and the under set at -115.

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Astros vs Red Sox Betting Trends

• The Astros have come away with 41 wins in the 77 contests they have been listed as the favorites in this season.
• This season Houston has been victorious five times in 11 chances when named as a favorite of at least -174 on the moneyline.
• Contests with the Astros have gone over the total set by oddsmakers in 53 of 119 chances this season.
• The Astros have an against the spread mark of 60-59-0 in 119 games with a line this season.
• The Red Sox have won 46.5% of the games this season they were the moneyline underdog (20-23).
• Boston has gone 3-5 when playing as a moneyline underdog with odds of +146 or longer (37.5%).
• In the 120 games bookmakers have set an over/under for the Red Sox, they have combined with opponents to go over the total 59 times (59-56-5).
• The Red Sox have a 68-52-0 record ATS this season.

Astros Player Leaders

• Jose Altuve has an OPS of .821, fueled by an OBP of .349 and a team-best slugging percentage of .472 this season. He has a .285 batting average.
• Among qualified hitters in MLB, his batting average ranks 22nd, his on-base percentage ranks 44th, and he is 37th in slugging.
• Jeremy Pena has 114 hits and an OBP of .374, both of which lead the Astros this season. He's batting .318 and slugging .486.
• Among qualifying hitters, his batting average ranks him second, his on-base percentage 13th, and his slugging percentage 30th.
• Pena heads into this matchup looking to extend his two-game hit streak. During his last five outings he is hitting .227 with a home run, a walk and an RBI.
• Yainer Diaz is batting .251 with a .414 slugging percentage and 50 RBI this year.
• Christian Walker has been key for Houston with 102 hits, an OBP of .300 plus a slugging percentage of .396.

Red Sox Player Leaders

• Jarren Duran has a .335 on-base percentage and a .456 slugging percentage, both team-best marks for the Red Sox. He's batting .265.
• Including all qualified players in the big leagues, he is 61st in batting average, 65th in on-base percentage and 58th in slugging percentage.
• Ceddanne Rafaela is hitting .259 with 24 doubles, three triples, 14 home runs and 20 walks. He's slugging .438 with an on-base percentage of .301.
• Including all qualified players, his batting average places him 77th, his on-base percentage is 130th, and he is 73rd in slugging.
• Trevor Story is hitting .256 with 19 doubles, 18 home runs and 25 walks.
• Wilyer Abreu paces his team with 85 hits.

Astros vs Red Sox Head to Head

• 8/12/2025: 14-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/11/2025: 7-6 HOU (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/3/2025: 6-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/2/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/1/2025: 2-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 4-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/20/2024: 6-5 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/19/2024: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/11/2024: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/10/2024: 5-4 HOU (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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