Astros vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 16

Odds updated as of 6:19 p.m.

Saturday's slate in the MLB includes a matchup between the Houston Astros and the Baltimore Orioles.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Astros vs Orioles Game Info

• Houston Astros (68-54) vs. Baltimore Orioles (56-66)
• Date: Saturday, August 16, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and MASN2

Astros vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-220) | BAL: (+184)
• Spread: HOU: -1.5 (-102) | BAL: +1.5 (-118)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Astros vs Orioles Probable Starting Pitchers

Probable Pitchers: Jason Alexander (Astros) - 3-1, 5.02 ERA vs Rico Garcia (Orioles) - 0-0, 3.71 ERA

The Astros will give the nod to Jason Alexander (3-1) against the Orioles and Rico Garcia. Alexander's team is 4-1-0 against the spread this season in his starts. Alexander's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. Garcia did not pitch as a moneyline underdog a season ago.

Astros vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.9%)

Astros vs Orioles Moneyline

• Houston is a -220 favorite on the moneyline, while Baltimore is a +184 underdog on the road.

Astros vs Orioles Spread

• The Astros are favored by 1.5 runs at home versus the Orioles. The Astros are -102 to cover the spread, while the Orioles are -118.

Astros vs Orioles Over/Under

• Astros versus Orioles on Aug. 16 has an over/under of 7.5 runs, with the odds on the over -112 and the under set at -108.

Bet on Houston Astros vs. Baltimore Orioles on FanDuel today!

Astros vs Orioles Betting Trends

• The Astros have been chosen as favorites in 79 games this year and have walked away with the win 42 times (53.2%) in those games.
• This year Houston has won four of seven games when listed as at least -220 on the moneyline.
• The Astros' games have gone over the total in 53 of their 121 opportunities.
• The Astros are 61-60-0 against the spread in their 121 games with a line set by sportsbooks this season.
• The Orioles have been the underdog on the moneyline 63 total times this season. They've gone 29-34 in those games.
• Baltimore has a record of 2-1 in games it has played as a moneyline underdog with odds of +184 or longer (66.7%).
• In the 119 games bookmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 50 times (50-65-4).
• The Orioles have collected a 54-65-0 record ATS this season.

Astros Player Leaders

• Jose Altuve has an OPS of .810, fueled by an OBP of .345 and a team-best slugging percentage of .465 this season. He has a .281 batting average.
• Among qualified batters, he ranks 26th in batting average, his on-base percentage ranks 51st, and he is 45th in slugging.
• Jeremy Pena leads Houston with 115 hits and an OBP of .373 this season. He's batting .318 and slugging .492.
• His batting average is second among qualified players, his on-base percentage 13th, and his slugging percentage 27th.
• Pena has picked up at least one hit in three straight games. During his last five outings he is batting .273 with two home runs, a walk and two RBIs.
• Yainer Diaz is batting .252 with a .420 slugging percentage and 53 RBI this year.
• Christian Walker has been key for Houston with 102 hits, an OBP of .298 plus a slugging percentage of .391.

Orioles Player Leaders

• Gunnar Henderson has 122 hits with a .351 on-base percentage and a .466 slugging percentage, all club-highs for the Orioles. He's batting .283.
• Including all qualified players in the big leagues, his batting average places him 24th, his on-base percentage is 42nd, and he is 42nd in slugging.
• Henderson enters this game on an eight-game hitting streak. During his last 10 outings he is hitting .257 with four doubles, a home run, two walks and six RBIs.
• Jackson Holliday has 16 doubles, two triples, 14 home runs and 29 walks while batting .248. He's slugging .385 with an on-base percentage of .300.
• Including all qualifying hitters, he ranks 102nd in batting average, 131st in on-base percentage and 128th in slugging percentage.
• Adley Rutschman is hitting .232 with 16 doubles, a triple, nine home runs and 37 walks.
• Jordan Westburg is hitting .268 with nine doubles, a triple, 14 home runs and 15 walks.

Astros vs Orioles Head to Head

• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/23/2024: 7-5 BAL (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2024: 6-0 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/23/2024: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/22/2024: 5-1 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/21/2024: 14-11 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/20/2023: 2-1 HOU (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/19/2023: 9-5 BAL (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)

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