Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 3:20 p.m.

MLB Opening Day on Thursday features the Houston Astros taking on the Los Angeles Angels.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Angels Game Info

• Houston Astros (0-0) vs. Los Angeles Angels (0-0)
• Date: Thursday, March 26, 2026
• Time: 4:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSW

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-184) | LAA: (+154)
• Spread: HOU: -1.5 (+122) | LAA: +1.5 (-146)
• Total: 8 -- Over: (-112) | Under: (-108)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 0-0, 0.00 ERA vs José Soriano (Angels) - 0-0, 0.00 ERA

The Astros will look to Hunter Brown against the Angels and Jose Soriano. In games Brown pitched with a spread last season, his team was 17-14-0 ATS. Brown appeared in 24 games last season as the moneyline favorite and his team finished with a record of 13-11 in those contests. Last season Soriano and his team had a 13-18-0 record against the spread in games he pitched. Soriano and his team put together a 11-9 record in games he appeared in when they were the moneyline underdog a season ago.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (64.7%)

Astros vs Angels Moneyline

• Houston is a -184 favorite on the moneyline, while Los Angeles is a +154 underdog on the road.

Astros vs Angels Spread

• The Astros are hosting the Angels and are favored by 1.5 runs (+122 to cover) on the runline. Los Angeles is -146 to cover.

Astros vs Angels Over/Under

• Astros versus Angels, on March 26, has an over/under of 8, with the over being -112 and the under -108.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros were chosen as favorites in 99 games last year and walked away with the win 53 times (53.5%) in those games.
• Last year, Houston won seven of 14 games when listed as at least -184 on the moneyline.
• The Astros and their opponents hit the over in 72 of their 161 games with a total last season.
• The Angels compiled a 52-69 record in games last season when they were listed as the moneyline underdog (winning 43% of those games).
• Los Angeles went 13-16 when it played as a moneyline underdog with odds of +154 or longer (44.8%).
• The Angels combined with their opponents to go over the total 84 times last season for an 84-71-5 record against the over/under.

Astros Player Leaders

• Last season, Jose Altuve finished with a slugging percentage of .442, fueled by 51 extra-base hits.
• Jeremy Pena finished with an OBP of .363 and 150 total hits.
• Yainer Diaz ended his last campaign with 139 hits, an OBP of .284, plus a slugging percentage of .417.
• Christian Walker slashed .238/.297/.421 and finished with an OPS of .717.

Angels Player Leaders

• Jo Adell had 124 hits and a batting average of .236 a season ago.
• Nolan Schanuel slugged .389 while batting .264.
• Zach Neto put up a slugging percentage of .474 and a batting average of .257 last season.
• Mike Trout had an on-base percentage of .359 while batting .232.

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