49ers vs Saints Prediction, Odds, Picks, Best Bets for NFL Week 2

The NFL schedule on Sunday includes the San Francisco 49ers facing the New Orleans Saints.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NFL betting odds.

49ers vs Saints Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (58.2%)

49ers vs Saints Point Spread

The 49ers are 3-point favorites against the Saints. The 49ers are -104 to cover the spread, while the Saints are -118 to cover as a 3-point underdog.

49ers vs Saints Over/Under

49ers versus Saints, on Sept. 14, has an over/under of 40.5, with the over being -110 and the under -110.

49ers vs Saints Moneyline

New Orleans is a +130 underdog on the moneyline, while San Francisco is a -154 favorite at home.

49ers vs Saints Betting Trends

• The 49ers were 5-12-0 against the spread last season.
• As 3-point favorites or more, the 49ers went 5-6 against the spread last season.
• There were 11 San Francisco games (out of 17) that went over the total last season.
• Against the spread, the Saints were 7-10-0 last year.
• Against the spread, as underdogs of 3 points or greater, New Orleans went 4-4 last season.
• There were eight Saints games (out of 17) that hit the over last year.

Check out even more in-depth 49ers vs. Saints analysis on FanDuel Research.

49ers vs Saints Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-154) | NO: (+130)
• Spread: SF: -3 (-104) | NO: +3 (-118)
• Total: 40.5 -- Over: (-110) | Under: (-110)

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