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NFL

2025 San Francisco 49ers Schedule, Results, TV Channel

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Data Skrive

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2025 San Francisco 49ers Schedule, Results, TV Channel

The San Francisco 49ers open their 2025 campaign with a game against the Seattle Seahawks on Sept. 7. For a glimpse at their full NFL schedule, keep reading. For details on the San Francisco 49ers, including their 2025 results, NFL schedule, and where they sit in the NFC West, read the below article.

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49ers' 2025 Schedule

Date/Time
Opponent
Odds/Score
Location
TV Channel
Sunday, Sept. 7 at 4:05 p.m. ET@ Seahawks49ers (-2.5) | O/U: 45.5Lumen Field, Seattle, WashingtonFOX
Sunday, Sept. 14 at 1 p.m. ET@ Saints-Caesars Superdome, New Orleans, LouisianaFOX
Sunday, Sept. 21 at 4:25 p.m. ETCardinals-Levi's Stadium, Santa Clara, CaliforniaFOX
Sunday, Sept. 28 at 4:05 p.m. ETJaguars-Levi's Stadium, Santa Clara, CaliforniaFOX
Thursday, Oct. 2 at 8:15 p.m. ET@ Rams-SoFi Stadium, Inglewood, CaliforniaAmazon Prime Video
Sunday, Oct. 12 at 1 p.m. ET@ Buccaneers-Raymond James Stadium, Tampa, FloridaCBS
Sunday, Oct. 19 at 8:20 p.m. ETFalcons-Levi's Stadium, Santa Clara, CaliforniaNBC

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