Yankees vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:12 p.m.

The New York Yankees are among the MLB teams in action on Wednesday, up against the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Yankees vs Red Sox Game Info

• New York Yankees (14-9) vs. Boston Red Sox (9-14)
• Date: Wednesday, April 22, 2026
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and Amazon Prime Video

Yankees vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-134) | BOS: (+114)
• Spread: NYY: -1.5 (+126) | BOS: +1.5 (-152)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Yankees vs Red Sox Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 2-1, 2.97 ERA vs Ranger Suarez (Red Sox) - 1-1, 3.22 ERA

The probable starters are Max Fried (2-1) for the Yankees and Ranger Suarez (1-1) for the Red Sox. Fried's team is 2-2-0 against the spread this season in his starts. Fried's team has won 50% of his starts when they are favored on the moneyline (2-2). The Red Sox have a 1-3-0 ATS record in Suarez's four starts with a set spread. The Red Sox have not been the underdog on the moneyline when Suarez starts this season.

Yankees vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (51.2%)

Yankees vs Red Sox Moneyline

• Boston is the underdog, +114 on the moneyline, while New York is a -134 favorite despite being on the road.

Yankees vs Red Sox Spread

• The Red Sox are at +1.5 on the runline against the Yankees. The Red Sox are -152 to cover the spread, and the Yankees are +126.

Yankees vs Red Sox Over/Under

• A total of 7.5 runs has been set for the Yankees-Red Sox game on April 22, with the over available at -110 and the under at -110.

Bet on New York Yankees vs. Boston Red Sox on FanDuel today!

Yankees vs Red Sox Betting Trends

• The Yankees have been chosen as favorites in 19 games this year and have walked away with the win 11 times (57.9%) in those games.
• New York has a record of 8-6 when favored by -134 or more this year.
• The Yankees and their opponents have hit the over in eight of their 21 games with a total set by oddsmakers this season.
• In 21 games with a line this season, the Yankees have a mark of 11-10-0 against the spread.
• The Red Sox have not yet won a game they played as the moneyline underdog this season, going 2-0.
• Boston has played as a moneyline underdog of +114 or longer in only two games this season, which it lost both.
• The Red Sox have played in 23 games with an over/under set, and have combined with their opponents to go over the total 12 times (12-11-0).
• The Red Sox have a 7-16-0 record against the spread this season (covering only 30.4% of the time).

Yankees Player Leaders

• Ben Rice has 22 hits and an OBP of .461 to go with a slugging percentage of .754. All three of those stats are tops among New York hitters this season. He has a .319 batting average, as well.
• Among qualifying hitters in the majors, his batting average ranks 11th, his on-base percentage ranks second, and he is second in slugging.
• Aaron Judge is hitting .235 with three doubles, nine home runs and 13 walks, while slugging .588 with an on-base percentage of .343.
• His batting average is 104th among qualified players, his on-base percentage 73rd, and his slugging percentage ninth.
• Judge takes a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .235 with a double, two home runs, five walks and three RBIs.
• Cody Bellinger has hit three homers with a team-high .456 SLG this season.
• Bellinger takes a nine-game hitting streak into this game. During his last 10 outings he is batting .324 with two doubles, two home runs, six walks and seven RBIs.
• Trent Grisham has three home runs, 14 RBI and a batting average of .167 this season.

Red Sox Player Leaders

• Wilyer Abreu has put up a slugging percentage of .459 and has 24 hits, both team-high figures for the Red Sox. He's batting .282 and with an on-base percentage of .337.
• Including all qualified hitters, he ranks 38th in batting average, while his on-base percentage is 78th and he is 52nd in slugging.
• Willson Contreras leads his team with a .398 on-base percentage. He has a batting average of .273 while slugging .455.
• Including all qualified players, his batting average places him 49th, his on-base percentage ranks 15th, and he is 56th in slugging.
• Roman Anthony has three doubles, a triple, a home run and 16 walks while batting .225.
• Ceddanne Rafaela has three doubles, a home run and five walks while batting .288.

Yankees vs Red Sox Head to Head

• 4/21/2026: 4-0 NYY (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 10/2/2025: 4-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/1/2025: 4-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/30/2025: 3-1 BOS (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/14/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/13/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/12/2025: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/24/2025: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/23/2025: 12-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/22/2025: 1-0 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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