Yankees vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 12:12 p.m.

The MLB schedule on Wednesday includes the New York Yankees taking on the Pittsburgh Pirates.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Pirates Game Info

• New York Yankees (56-44) vs. Pittsburgh Pirates (52-49)
• Date: Wednesday, July 22, 2026
• Time: 1:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and SportsNet PT

Yankees vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-184) | PIT: (+154)
• Spread: NYY: -1.5 (+106) | PIT: +1.5 (-128)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Yankees vs Pirates Probable Starting Pitchers

Probable Pitchers: Gerrit Cole (Yankees) - 3-5, 3.93 ERA vs Mitch Keller (Pirates) - 6-7, 5.14 ERA

The Yankees will give the ball to Gerrit Cole (3-5, 3.93 ERA), who is eyeing win No. 4 on the season, and the Pirates will turn to Mitch Keller (6-7, 5.14 ERA). Cole and his team are 4-6-0 ATS this season when he starts. Cole's team is 4-4 this season when he starts and they are the moneyline favorite. When Keller starts, the Pirates are 8-10-0 against the spread. The Pirates have a 5-8 record in Keller's 13 starts this season when they were the moneyline underdog.

Yankees vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (53.8%)

Yankees vs Pirates Moneyline

• The Yankees vs Pirates moneyline has New York as a -184 favorite, while Pittsburgh is a +154 underdog on the road.

Yankees vs Pirates Spread

• The Yankees are 1.5-run home favorites on the runline against the Pirates. The Yankees are +106 to cover, and the Pirates are -128.

Yankees vs Pirates Over/Under

• The over/under for Yankees-Pirates on July 22 is 9.5. The over is -110, and the under is -110.

Bet on New York Yankees vs. Pittsburgh Pirates on FanDuel today!

Yankees vs Pirates Betting Trends

• The Yankees have been victorious in 47, or 58.8%, of the 80 contests they have been chosen as favorites in this season.
• This season New York has been victorious 11 times in 16 chances when named as a favorite of at least -184 on the moneyline.
• The Yankees' games have gone over the total in 43 of their 97 opportunities.
• The Yankees have an against the spread record of 47-50-0 in 97 games with a line this season.
• The Pirates have won 44.4% of the games this season they were the moneyline underdog (20-25).
• Pittsburgh has a record of 2-1 when playing as a moneyline underdog with odds of +154 or longer (66.7%).
• In the 99 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 59 times (59-38-2).
• The Pirates have covered 51.5% of their games this season, going 51-48-0 ATS.

Yankees Player Leaders

• Ben Rice leads New York with 99 hits and an OBP of .372, plus a team-best slugging percentage of .594. He's batting .281.
• Among all qualifying hitters in MLB, he is 34th in batting average, 20th in on-base percentage, and second in slugging.
• Rice has recorded a base hit in 12 games in a row. In his last 10 games he is batting .405 with two doubles, a triple, four home runs, five walks and 11 RBIs.
• Cody Bellinger is batting .255 with 19 doubles, three triples, 11 home runs and 52 walks. He's slugging .416 with an on-base percentage of .344.
• His batting average ranks 79th among qualified players, his on-base percentage 58th, and his slugging percentage 85th.
• Bellinger has picked up at least one hit in two straight games. In his last five games he is hitting .353 with a double, two walks and an RBI.
• Trent Grisham has collected 62 base hits, an OBP of .328 and a slugging percentage of .412 this season.
• Jazz Chisholm is batting .228 with a .304 OBP and 43 RBI for New York this season.
• Chisholm brings a five-game hitting streak into this matchup. In his last five games he is batting .368 with two doubles, three home runs and seven RBIs.

Pirates Player Leaders

• Bryan Reynolds has put up an on-base percentage of .399, a team-high for the Pirates. He's batting .282 and slugging .474.
• Including all the qualifying hitters in the big leagues, his batting average is 29th, his on-base percentage ranks fifth, and he is 36th in slugging.
• Brandon Lowe's 90 hits pace his team. He has a batting average of .245 while slugging .478 with an on-base percentage of .313.
• Including all qualified hitters, he is 97th in batting average, 101st in on-base percentage and 29th in slugging percentage.
• Ryan O'Hearn is batting .281 with 13 doubles, 16 home runs and 28 walks.
• Nick Gonzales is slugging .404 to pace his team.

Yankees vs Pirates Head to Head

• 7/20/2026: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2025: 5-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/5/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/4/2025: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/28/2024: 9-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/27/2024: 4-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/17/2023: 3-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/16/2023: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/15/2023: 7-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/21/2022: 14-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -295, Underdog Moneyline: +240)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!