Mariners vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 3:11 p.m.

The MLB's Wednesday schedule includes the Seattle Mariners taking on the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Mariners vs Reds Game Info

• Seattle Mariners (51-51) vs. Cincinnati Reds (46-54)
• Date: Wednesday, July 22, 2026
• Time: 3:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and Reds.TV

Mariners vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-118) | CIN: (+100)
• Spread: SEA: +1.5 (-205) | CIN: -1.5 (+168)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Mariners vs Reds Probable Starting Pitchers

Probable Pitchers: Emerson Hancock (Mariners) - 6-4, 3.17 ERA vs Brady Singer (Reds) - 4-9, 4.56 ERA

The Mariners will give the ball to Emerson Hancock (6-4, 3.17 ERA), who is eyeing win No. 7 on the season, and the Reds will turn to Brady Singer (4-9, 4.56 ERA). When Hancock starts, his team is 7-11-0 against the spread this season. Hancock's team has been victorious in 57.1% of the games he's started as the moneyline favorite with a record of 8-6. When Singer starts, the Reds have gone 11-7-0 against the spread. The Reds have been the underdog on the moneyline in 16 of Singer's starts this season, and they went 6-10 in those games.

Mariners vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (63.1%)

Mariners vs Reds Moneyline

• Seattle is a -118 favorite on the moneyline, while Cincinnati is a +100 underdog on the road.

Mariners vs Reds Spread

• The Reds are 1.5-run favorites against the spread for this matchup with the Mariners. The Reds are +168 to cover, while the Mariners are -205 to cover as a 1.5-run underdog on the runline.

Mariners vs Reds Over/Under

• The over/under for Mariners-Reds on July 22 is 7.5. The over is -112, and the under is -108.

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Mariners vs Reds Betting Trends

• The Mariners have been chosen as favorites in 86 games this year and have walked away with the win 46 times (53.5%) in those games.
• This year Seattle has won 44 of 79 games when listed as at least -118 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 48 of their 101 opportunities.
• The Mariners have an against the spread mark of 37-64-0 in 101 games with a line this season.
• The Reds are 30-36 in games they were the underdog on the moneyline (winning 45.5% of those games).
• Cincinnati has a 20-35 record (winning just 36.4% of its games) when playing as a moneyline underdog of +100 or longer.
• The Reds have played in 98 games with an over/under set, and have combined with opponents to go over the total 55 times (55-42-1).
• The Reds have a 53-45-0 record ATS this season (covering 54.1% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle with 96 hits and an OBP of .382, plus a team-best slugging percentage of .446. He's batting .282.
• Among qualified hitters in baseball, his batting average ranks 29th, his on-base percentage ranks 14th, and he is 60th in slugging.
• Josh Naylor has hit eight homers this season while driving in 37 runs. He's batting .258 this season and slugging .355 with an on-base percentage of .321.
• Among qualifying hitters, his batting average places him 66th, his on-base percentage 92nd, and his slugging percentage 128th.
• Naylor heads into this matchup looking to extend his three-game hit streak. During his last five outings he is batting .368 with a walk and an RBI.
• Julio Rodriguez has 92 hits this season and has a slash line of .258/.321/.426.
• Rodriguez brings a three-game hitting streak into this matchup. During his last five outings he is batting .231 with a home run, two walks and three RBIs.
• Cole Young has been key for Seattle with 92 hits, an OBP of .310 plus a slugging percentage of .401.

Reds Player Leaders

• Sal Stewart has a team-best .466 slugging percentage. He's batting .249 with an on-base percentage of .328.
• Including all the qualifying hitters in the big leagues, his batting average puts him 86th, his on-base percentage is 80th, and he is 43rd in slugging.
• Elly De La Cruz has racked up 90 hits with a .354 OBP to lead his team in both. He has a batting average of .280 while slugging .509.
• Including all qualified hitters, he ranks 38th in batting average, 40th in on-base percentage and 18th in slugging percentage.
• Spencer Steer is hitting .245 with 14 doubles, 16 home runs and 34 walks.
• JJ Bleday has 11 doubles, a triple, 16 home runs and 41 walks while hitting .236.

Mariners vs Reds Head to Head

• 7/21/2026: 4-2 CIN (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/20/2026: 8-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/17/2025: 11-7 SEA (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/15/2025: 8-4 CIN (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/17/2024: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2024: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/15/2024: 9-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/6/2023: 8-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/5/2023: 7-6 CIN (Favorite: Mariners, Spread: -1.5, Total: 10.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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