Yankees vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:12 p.m.

On Wednesday in MLB, the New York Yankees are up against the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Yankees vs Pirates Game Info

• New York Yankees (56-45) vs. Pittsburgh Pirates (53-49)
• Date: Wednesday, July 22, 2026
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and SportsNet PT

Yankees vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-190) | PIT: (+160)
• Spread: NYY: -1.5 (+106) | PIT: +1.5 (-128)
• Total: 9.5 -- Over: (-108) | Under: (-112)

Yankees vs Pirates Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 4-3, 3.21 ERA vs Bubba Chandler (Pirates) - 3-8, 4.77 ERA

This contest's pitching matchup is set, as the Yankees will send Max Fried (4-3) to the mound, while Bubba Chandler (3-8) will take the ball for the Pirates. When Fried starts, his team is 5-4-0 against the spread this season. Fried's team has won 55.6% of his starts when they are favored on the moneyline (5-4). The Pirates are 9-9-0 against the spread when Chandler starts. The Pirates have a 4-7 record in Chandler's 11 starts this season when they were the underdog on the moneyline.

Yankees vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (57.1%)

Yankees vs Pirates Moneyline

• Pittsburgh is the underdog, +160 on the moneyline, while New York is a -190 favorite at home.

Yankees vs Pirates Spread

• The Pirates are at the Yankees, and are +1.5 on the runline. The Pirates are +106 to cover the spread, and the Yankees are -128.

Yankees vs Pirates Over/Under

• Yankees versus Pirates, on July 22, has an over/under of 9.5, with the over being -108 and the under -112.

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Yankees vs Pirates Betting Trends

• The Yankees have been victorious in 47, or 58%, of the 81 contests they have been chosen as favorites in this season.
• This year New York has won nine of 15 games when listed as at least -190 on the moneyline.
• The Yankees' games have gone over the total in 43 of their 98 opportunities.
• The Yankees have an against the spread mark of 47-51-0 in 98 games with a line this season.
• The Pirates are 21-25 in games they were the underdog on the moneyline (winning 45.7% of those games).
• Pittsburgh has played as a moneyline underdog of +160 or longer in only two games this season, which it split 1-1.
• The Pirates have played in 100 games with an over/under set, and have combined with opponents to go over the total 59 times (59-39-2).
• The Pirates have covered 52% of their games this season, going 52-48-0 against the spread.

Yankees Player Leaders

• Ben Rice leads New York in OBP (.370), slugging percentage (.597) and total hits (100) this season. He has a .280 batting average.
• Among qualified hitters, he is 35th in batting average, his on-base percentage ranks 20th, and he is second in slugging.
• Rice has picked up at least one hit in 13 straight games. During his last 10 games he is batting .342 with two doubles, a triple, four home runs, five walks and 11 RBIs.
• Cody Bellinger is batting .255 with 19 doubles, three triples, 11 home runs and 53 walks. He's slugging .414 with an on-base percentage of .345.
• Among qualified hitters, he is 79th in batting average, 56th in on-base percentage and 86th in slugging percentage.
• Bellinger has picked up a hit in three straight games. During his last five outings he is batting .278 with two walks and an RBI.
• Trent Grisham has collected 63 base hits, an OBP of .329 and a slugging percentage of .410 this season.
• Jazz Chisholm has been key for New York with 76 hits, an OBP of .300 plus a slugging percentage of .416.

Pirates Player Leaders

• Bryan Reynolds has racked up a team-high .394 on-base percentage. He's batting .278 and slugging .468.
• Including all qualifying hitters in the big leagues, his batting average places him 40th, his on-base percentage ranks fifth, and he is 41st in slugging.
• Brandon Lowe has collected 91 hits to lead his team. He has a batting average of .245 while slugging .476 with an on-base percentage of .314.
• Including all qualifying hitters, his batting average puts him 95th, his on-base percentage ranks 99th, and he is 30th in slugging.
• Nick Gonzales has accumulated a slugging percentage of .414, a team-best for the Pirates.
• Ryan O'Hearn is batting .278 with 13 doubles, 16 home runs and 28 walks.

Yankees vs Pirates Head to Head

• 7/22/2026: 5-3 PIT (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/20/2026: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2025: 5-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/5/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/4/2025: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/28/2024: 9-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/27/2024: 4-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/17/2023: 3-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/16/2023: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/15/2023: 7-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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