Yankees vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 7:12 a.m.

Tuesday's slate in the MLB includes a matchup between the New York Yankees and the Pittsburgh Pirates.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Pirates Game Info

• New York Yankees (56-44) vs. Pittsburgh Pirates (52-49)
• Date: Tuesday, July 21, 2026
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and SportsNet PT

Yankees vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-148) | PIT: (+126)
• Spread: NYY: -1.5 (+140) | PIT: +1.5 (-170)
• Total: 9 -- Over: (-110) | Under: (-110)

Yankees vs Pirates Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 7-4, 4.03 ERA vs Bubba Chandler (Pirates) - 3-8, 4.77 ERA

The Yankees will give the nod to Will Warren (7-4, 4.03 ERA), who is eyeing win No. 8 on the season, and the Pirates will turn to Bubba Chandler (3-8, 4.77 ERA). Warren's team is 10-9-0 against the spread in his starts this season. Warren's team has a record of 11-4 this season when he starts and they are the favorite on the moneyline. The Pirates are 9-9-0 ATS in Chandler's 18 starts with a set spread. The Pirates have a 4-7 record in Chandler's 11 starts this season when they were the underdog on the moneyline.

Yankees vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (53.4%)

Yankees vs Pirates Moneyline

• The moneyline numbers for Yankees vs. Pirates reveal New York as the favorite (-148) and Pittsburgh as the underdog (+126) on the road.

Yankees vs Pirates Spread

• The Yankees are hosting the Pirates and are favored by 1.5 runs on the spread. The Yankees are +140 to cover the runline, with the Pirates being -170.

Yankees vs Pirates Over/Under

• A combined run total of 9 has been set for Yankees-Pirates on July 21, with the over at -110 and the under at -110.

Bet on New York Yankees vs. Pittsburgh Pirates on FanDuel today!

Yankees vs Pirates Betting Trends

• The Yankees have come away with 47 wins in the 80 contests they have been listed as the favorites in this season.
• This season New York has come away with a win 26 times in 41 chances when named as a favorite of at least -148 on the moneyline.
• The Yankees and their opponents have hit the over in 43 of their 97 games with a total set by oddsmakers this season.
• The Yankees are 47-50-0 against the spread in their 97 games that had a posted line this season.
• The Pirates have won 20 of the 45 games they were listed as the moneyline underdog this season (44.4%).
• Pittsburgh is 4-7 (winning just 36.4% of its games) when playing as a moneyline underdog of +126 or longer.
• In the 99 games bookmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 59 times (59-38-2).
• The Pirates are 51-48-0 ATS this season.

Yankees Player Leaders

• Ben Rice leads New York in OBP (.372), slugging percentage (.594) and total hits (99) this season. He has a .281 batting average.
• Among the qualifying hitters in the majors, his batting average ranks 32nd, his on-base percentage ranks 20th, and he is second in slugging.
• Rice has recorded at least one hit in 12 straight games. In his last 10 games he is hitting .405 with two doubles, a triple, four home runs, five walks and 11 RBIs.
• Cody Bellinger is batting .255 with 19 doubles, three triples, 11 home runs and 52 walks, while slugging .416 with an on-base percentage of .344.
• Among qualified hitters, his batting average ranks him 76th, his on-base percentage 57th, and his slugging percentage 87th.
• Bellinger has picked up a hit in two straight games. During his last five outings he is hitting .353 with a double, two walks and an RBI.
• Trent Grisham has collected 62 base hits, an OBP of .328 and a slugging percentage of .412 this season.
• Jazz Chisholm has been key for New York with 76 hits, an OBP of .304 plus a slugging percentage of .422.
• Chisholm has safely hit in five games in a row. During his last five outings he is hitting .368 with two doubles, three home runs and seven RBIs.

Pirates Player Leaders

• Bryan Reynolds has put up a team-high .399 on-base percentage. He's batting .282 and slugging .474.
• Including all the qualified hitters in the majors, his batting average is 28th, his on-base percentage is fifth, and he is 38th in slugging.
• Brandon Lowe's 90 hits lead his team. He has a batting average of .245 while slugging .478 with an on-base percentage of .313.
• He ranks 95th in batting average, 105th in on-base percentage and 32nd in slugging percentage in the big leagues.
• Ryan O'Hearn is batting .281 with 13 doubles, 16 home runs and 28 walks.
• Nick Gonzales' .404 slugging percentage paces his team.

Yankees vs Pirates Head to Head

• 7/20/2026: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2025: 5-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/5/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/4/2025: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/28/2024: 9-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/27/2024: 4-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/17/2023: 3-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/16/2023: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/15/2023: 7-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/21/2022: 14-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -295, Underdog Moneyline: +240)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!