Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:11 a.m.

On Monday in MLB, the New York Yankees are playing the San Diego Padres.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Padres Game Info

• New York Yankees (19-15) vs. San Diego Padres (22-11)
• Date: Monday, May 5, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: MLB Network, YES, and SDPA

Yankees vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-142) | SD: (+120)
• Spread: NYY: -1.5 (+140) | SD: +1.5 (-170)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Yankees vs Padres Probable Starting Pitchers

Probable Pitchers: Carlos Rodon (Yankees) - 4-3, 3.43 ERA vs Nicholas Pivetta (Padres) - 5-1, 1.78 ERA

This contest's pitching matchup is set, as the Yankees will send Carlos Rodon (4-3) to the mound, while Nicholas Pivetta (5-1) will take the ball for the Padres. Rodon and his team are 3-4-0 ATS this season when he starts. When Rodon starts a game and his team is the favorite on the moneyline, they have a record of 4-3. The Padres have a 5-1-0 record against the spread in Pivetta's starts. The Padres are 2-1 in Pivetta's three starts this season that they were the moneyline underdog.

Yankees vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (54.6%)

Yankees vs Padres Moneyline

• New York is the favorite, -142 on the moneyline, while San Diego is a +120 underdog on the road.

Yankees vs Padres Spread

• The Padres are at the Yankees, and are +1.5 on the runline. The Padres are +140 to cover the spread, and the Yankees are -170.

Yankees vs Padres Over/Under

• Yankees versus Padres on May 5 has an over/under of 7.5 runs, with the odds on the over -114 and the under set at -106.

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Yankees vs Padres Betting Trends

• The Yankees have been favorites in 27 games this season and have come away with the win 17 times (63%) in those contests.
• New York has a record of 13-6 in contests when sportsbooks favor them by -142 or more on the moneyline.
• The Yankees' games have gone over the total in 15 of their 33 opportunities.
• The Yankees are 16-17-0 against the spread in their 33 games that had a posted line this season.
• The Padres have been the moneyline underdog 14 total times this season. They've gone 7-7 in those games.
• San Diego is 1-4 (winning just 20% of its games) when playing as a moneyline underdog of +120 or longer.
• In the 32 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 13 times (13-18-1).
• The Padres have covered 59.4% of their games this season, going 19-13-0 against the spread.

Yankees Player Leaders

• Aaron Judge has 55 hits and an OBP of .510 to go with a slugging percentage of .777. All three of those stats rank first among New York hitters this season. He has a .423 batting average, as well.
• Among all qualifying hitters in baseball, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Judge has picked up at least one hit in 14 straight games. In his last 10 outings he is batting .450 with two doubles, two triples, four home runs, five walks and eight RBI.
• Paul Goldschmidt has eight doubles, three home runs and 10 walks. He's batting .349 and slugging .481 with an on-base percentage of .397.
• He ranks second in batting average, 11th in on-base percentage and 36th in slugging among qualifying hitters.
• Ben Rice has 26 hits this season and has a slash line of .255/.361/.559.
• Anthony Volpe is batting .233 with a .326 OBP and 19 RBI for New York this season.

Padres Player Leaders

• Fernando Tatis Jr. has an on-base percentage of .399, a slugging percentage of .574, and has 40 hits, all club-highs for the Padres (while batting .328).
• Including all qualifying players in the majors, he is seventh in batting average, eighth in on-base percentage and eighth in slugging percentage.
• Manny Machado is batting .295 with 11 doubles, three home runs and 13 walks. He's slugging .459 with an on-base percentage of .360.
• His batting average ranks 23rd among all qualified players, his on-base percentage ranks 42nd, and he is 49th in slugging.
• Luis Arraez is hitting .306 with four doubles, a triple, three home runs and five walks.
• Xander Bogaerts has nine doubles, a home run and 15 walks while batting .243.

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