White Sox vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for July 25

Odds updated as of 6:12 p.m.

The Saturday slate in MLB includes a matchup between the Chicago White Sox and the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Astros Game Info

• Chicago White Sox (54-48) vs. Houston Astros (51-54)
• Date: Saturday, July 25, 2026
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SCHN

White Sox vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-120) | HOU: (+102)
• Spread: CHW: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (-115) | Under: (-105)

White Sox vs Astros Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 7-4, 3.20 ERA vs Hunter Brown (Astros) - 1-1, 4.05 ERA

The White Sox will give the nod to Sean Burke (7-4, 3.20 ERA), who is eyeing win No. 8 on the season, and the Astros will counter with Hunter Brown (1-1, 4.05 ERA). Burke and his team are 8-8-0 ATS this season when he starts. Burke and his team have won each of the three games he's started as the moneyline favorite. The Astros have gone 4-4-0 ATS in Brown's eight starts with a set spread. The Astros were named the moneyline underdog for one Brown start this season -- they lost.

White Sox vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (59.3%)

White Sox vs Astros Moneyline

• Houston is a +102 underdog on the moneyline, while Chicago is a -120 favorite at home.

White Sox vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the White Sox. The Astros are +168 to cover, while the White Sox are -205 to cover as a 1.5-run underdog on the runline.

White Sox vs Astros Over/Under

• The over/under for the White Sox versus Astros contest on July 25 has been set at 8.5, with -115 odds on the over and -105 odds on the under.

Bet on Chicago White Sox vs. Houston Astros on FanDuel today!

White Sox vs Astros Betting Trends

• The White Sox have been victorious in 11, or 61.1%, of the 18 contests they have been chosen as favorites in this season.
• Chicago has a record of 10-5 when favored by -120 or more this year.
• The White Sox and their opponents have hit the over in 55 of their 99 games with a total set by oddsmakers this season.
• The White Sox have an against the spread mark of 57-42-0 in 99 games with a line this season.
• The Astros have been the underdog on the moneyline 61 total times this season. They've gone 31-30 in those games.
• Houston is 25-22 (winning 53.2% of its games) when it has played as a moneyline underdog of +102 or longer.
• The Astros have played in 105 games with a set over/under, and have combined with their opponents to go over the total 55 times (55-46-4).
• The Astros have a 51-54-0 record against the spread this season (covering 48.6% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (90) this season while batting .243 with 46 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .482.
• He is 96th in batting average, 47th in on-base percentage, and 30th in slugging among all qualified hitters in the majors.
• Sam Antonacci has 81 hits this season and a team-best OBP of .373. He's batting .281 and slugging .413.
• Among qualifiers, he ranks 31st in batting average, 19th in on-base percentage and 87th in slugging percentage.
• Colson Montgomery has collected 79 base hits, an OBP of .300 and a slugging percentage of .463 this season.
• Chase Meidroth leads Chicago in slugging percentage (.384) thanks to 25 extra-base hits.
• Meidroth heads into this game on a two-game hitting streak. During his last five outings he is hitting .412 with a double, a walk and four RBIs.

Astros Player Leaders

• Yordan Alvarez has a team-best OBP (.432) and slugging percentage (.652), and paces the Astros in hits (123, while batting .327).
• Including all the qualified hitters in MLB, his batting average is second, his on-base percentage is first, and he is first in slugging.
• Alvarez enters this game on a 10-game hitting streak. During his last 10 outings he is hitting .486 with four doubles, five home runs, eight walks and 10 RBIs.
• Isaac Paredes is batting .261 with 18 doubles, a triple, 14 home runs and 40 walks. He's slugging .434 with an on-base percentage of .354.
• He is currently 64th in batting average, 42nd in on-base percentage and 66th in slugging percentage among all qualified batters.
• Christian Walker is batting .233 with 20 doubles, a triple, 20 home runs and 33 walks.
• Jose Altuve is batting .238 with 14 doubles, a triple, 12 home runs and 29 walks.

White Sox vs Astros Head to Head

• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/18/2024: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/17/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/16/2024: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)

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