White Sox vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for July 25

Odds updated as of 1:12 a.m.

The Chicago White Sox versus the Houston Astros is on the MLB schedule for Saturday.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Astros Game Info

• Chicago White Sox (54-48) vs. Houston Astros (51-54)
• Date: Saturday, July 25, 2026
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SCHN

White Sox vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-120) | HOU: (+102)
• Spread: CHW: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (-108) | Under: (-112)

White Sox vs Astros Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 7-4, 3.20 ERA vs Hunter Brown (Astros) - 1-1, 4.05 ERA

The probable pitchers are Sean Burke (7-4) for the White Sox and Hunter Brown (1-1) for the Astros. Burke and his team are 8-8-0 ATS this season when he starts. Burke has started three games with his team as the moneyline favorite and won each of them. The Astros have gone 4-4-0 ATS in Brown's eight starts that had a set spread. The Astros were the moneyline underdog for one Brown start this season -- they lost.

White Sox vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (58.8%)

White Sox vs Astros Moneyline

• Chicago is the favorite, -120 on the moneyline, while Houston is a +102 underdog on the road.

White Sox vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the White Sox. The Astros are +168 to cover, while the White Sox are -205 to cover as a 1.5-run underdog on the runline.

White Sox vs Astros Over/Under

• White Sox versus Astros, on July 25, has an over/under of 8.5, with the over being -108 and the under -112.

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White Sox vs Astros Betting Trends

• The White Sox have been chosen as favorites in 18 games this year and have walked away with the win 11 times (61.1%) in those games.
• This year Chicago has won 10 of 15 games when listed as at least -120 on the moneyline.
• Contests with the White Sox have gone over the total set by oddsmakers in 55 of 99 chances this season.
• The White Sox have posted a record of 57-42-0 against the spread this season.
• The Astros have won 50.8% of the games this season they were the moneyline underdog (31-30).
• Houston has gone 25-22 in games it has played as a moneyline underdog with odds of +102 or longer (53.2%).
• In the 105 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 55 times (55-46-4).
• The Astros have covered 48.6% of their games this season, going 51-54-0 against the spread.

White Sox Player Leaders

• Miguel Vargas leads Chicago with 90 hits, batting .243 this season with 46 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .482.
• Among all qualified batters in baseball, he ranks 96th in batting average, 47th in on-base percentage, and 30th in slugging.
• Sam Antonacci has 81 hits this season and a team-best OBP of .373. He's batting .281 and slugging .413.
• He is 30th in batting average, 18th in on-base percentage and 87th in slugging in the majors.
• Colson Montgomery has collected 79 base hits, an OBP of .300 and a slugging percentage of .463 this season.
• Chase Meidroth leads Chicago in slugging percentage (.384) thanks to 25 extra-base hits.
• Meidroth enters this game on a two-game hitting streak. In his last five games he is batting .412 with a double, a walk and four RBIs.

Astros Player Leaders

• Yordan Alvarez has accumulated 123 hits with a .432 on-base percentage and a .652 slugging percentage, all club-bests for the Astros. He's batting .327.
• Including all the qualifying hitters in the majors, he ranks second in batting average, first in on-base percentage and first in slugging percentage.
• Alvarez takes a 10-game hitting streak into this game. In his last 10 outings he is batting .486 with four doubles, five home runs, eight walks and 10 RBIs.
• Isaac Paredes has 18 doubles, a triple, 14 home runs and 40 walks while hitting .261. He's slugging .434 with an on-base percentage of .354.
• His batting average ranks 64th among all qualified players, his on-base percentage is 42nd, and he is 66th in slugging.
• Christian Walker is batting .233 with 20 doubles, a triple, 20 home runs and 33 walks.
• Jose Altuve is hitting .238 with 14 doubles, a triple, 12 home runs and 29 walks.

White Sox vs Astros Head to Head

• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/18/2024: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/17/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/16/2024: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)

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