Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for July 25

Odds updated as of 1:12 a.m.

On Saturday in MLB, the Pittsburgh Pirates are playing the Chicago Cubs.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (53-51) vs. Chicago Cubs (58-45)
• Date: Saturday, July 25, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-132) | CHC: (+112)
• Spread: PIT: -1.5 (+168) | CHC: +1.5 (-205)
• Total: 8 -- Over: (-108) | Under: (-112)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 9-8, 3.43 ERA vs Shota Imanaga (Cubs) - 6-8, 3.91 ERA

This contest's pitching matchup is set, as the Pirates will send Paul Skenes (9-8) to the mound, while Shota Imanaga (6-8) will answer the bell for the Cubs. Skenes' team is 8-13-0 against the spread this season in his starts. Skenes' team has won 44.4% of his starts when they are favored on the moneyline (8-10). The Cubs have a 6-13-0 record against the spread in Imanaga's starts. The Cubs were named the moneyline underdog for two Imanaga starts this season -- they split the games.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (58.8%)

Pirates vs Cubs Moneyline

• Chicago is the underdog, +112 on the moneyline, while Pittsburgh is a -132 favorite at home.

Pirates vs Cubs Spread

• The Cubs are +1.5 on the run line against the Pirates. The Cubs are -205 to cover, and the Pirates are +168.

Pirates vs Cubs Over/Under

• The over/under for the Pirates versus Cubs contest on July 25 has been set at 8, with -108 odds on the over and -112 odds on the under.

Bet on Pittsburgh Pirates vs. Chicago Cubs on FanDuel today!

Pirates vs Cubs Betting Trends

• The Pirates have come away with 31 wins in the 53 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 17-17 when favored by -132 or more this year.
• The Pirates and their opponents have hit the over in 59 of their 102 games with a total set by oddsmakers this season.
• In 102 games with a line this season, the Pirates have a mark of 53-49-0 against the spread.
• The Cubs are 16-13 in games they were listed as the moneyline underdog (winning 55.2% of those games).
• Chicago has a record of 7-4 when it has played as a moneyline underdog with odds of +112 or longer (63.6%).
• The Cubs have combined with opponents to hit the over on the total 53 times this season for a 53-46-0 record against the over/under.
• The Cubs have put together a 44-55-0 record ATS this season (covering 44.4% of the time).

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh in OBP (.386) this season, fueled by 103 hits. He has a .272 batting average and a slugging percentage of .456.
• Among the qualifying hitters in MLB, his batting average ranks 46th, his on-base percentage ranks ninth, and he is 51st in slugging.
• Brandon Lowe leads Pittsburgh in total hits (91) this season while batting .241 with 43 extra-base hits. He's slugging .468 with an on-base percentage of .311.
• His batting average ranks 100th among qualified players, his on-base percentage 106th, and his slugging percentage 38th.
• Nick Gonzales has an OPS of .781, fueled by an OBP of .369 and a team-best slugging percentage of .412 this season.
• Gonzales takes an eight-game hitting streak into this game. In his last 10 games he is hitting .326 with four doubles, two home runs, a walk and six RBIs.
• Ryan O'Hearn has been key for Pittsburgh with 92 hits, an OBP of .340 plus a slugging percentage of .461.

Cubs Player Leaders

• Pete Crow-Armstrong has a team-best OBP (.385) and slugging percentage (.527), while pacing the Cubs in hits (109, while batting .285).
• Including all the qualifying hitters in MLB, his batting average ranks 22nd, his on-base percentage ranks 10th, and he is 14th in slugging.
• Nico Hoerner is hitting .244 with 23 doubles, a triple, four home runs and 36 walks. He's slugging .336 with an on-base percentage of .310.
• His batting average is 94th among all qualified players, his on-base percentage ranks 109th, and he is 141st in slugging.
• Dansby Swanson has 12 doubles, three triples, 16 home runs and 39 walks while hitting .213.
• Alex Bregman has 15 doubles, a triple, 10 home runs and 52 walks while batting .237.

Pirates vs Cubs Head to Head

• 7/24/2026: 3-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/28/2026: 7-2 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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