USC vs Purdue Prediction, Odds, Picks, Best Bets for Week 3 2025

The college football slate on Saturday includes the USC Trojans taking on the Purdue Boilermakers.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

USC vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-1587) | Purdue: (+860)
• Spread: USC: -21.5 (-102) | Purdue: +21.5 (-120)
• Total: 59.5 -- Over: (-105) | Under: (-115)

USC vs Purdue Betting Trends

• USC has two wins against the spread this season.
• USC has covered every time (2-0) as a 21.5-point favorite or greater this year.
• Every USC game has hit the over this year.
• Purdue has posted one win against the spread this year.
• None of Purdue's two games has gone over the point total in 2025.

USC vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (91.1%)

USC vs Purdue Point Spread

Purdue is listed as an underdog by 21.5 points (-120 odds), and USC, the favorite, is -102 to cover.

USC vs Purdue Over/Under

The USC-Purdue game on Sept. 13 has been given an over/under of 59.5 points. The over is -105 and the under is -115.

USC vs Purdue Moneyline

Purdue is a +860 underdog on the moneyline, while USC is a -1587 favorite.

USC vs. Purdue Points Insights

USC vs. Purdue Game Info

• Game day: Saturday, September 13, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth USC vs. Purdue analysis on FanDuel Research.