USC vs Northwestern Prediction, Odds, Picks, Best Bets for Week 11 2025

On Friday in college football, the USC Trojans are up against the Northwestern Wildcats.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

USC vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-649) | Northwestern: (+460)
• Spread: USC: -13.5 (-118) | Northwestern: +13.5 (-104)
• Total: 51.5 -- Over: (-115) | Under: (-105)

USC vs Northwestern Betting Trends

• USC has four wins in eight games against the spread this season.
• USC has won twice ATS (2-2) as a 13.5-point or bigger favorite this year.
• This season, four of USC's eight games have hit the over.
• Northwestern is 6-2-0 against the spread this season.
• Northwestern has covered every time (2-0) as a 13.5-point or greater underdog this year.
• Northwestern has played two games (out of eight) which finished over the total this season.

USC vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (86.3%)

USC vs Northwestern Point Spread

Northwestern is an underdog by 13.5 points against USC. Northwestern is -104 to cover the spread, and USC is -118.

USC vs Northwestern Over/Under

A total of 51.5 points has been set for the USC-Northwestern game on Nov. 7, with the over available at -115 and the under at -105.

USC vs Northwestern Moneyline

The moneyline numbers for USC vs. Northwestern reveal USC as the favorite (-649) and Northwestern as the underdog (+460).

USC vs. Northwestern Points Insights

USC vs. Northwestern Game Info

• Game day: Friday, November 7, 2025
• Game time: 9 p.m. ET
• TV channel: FOX
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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