UConn vs Buffalo Prediction, Odds, Picks, Best Bets for Week 5 2025

The college football slate on Saturday includes the UConn Huskies facing the Buffalo Bulls.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

UConn vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: UConn: (-170) | Buffalo: (+140)
• Spread: UConn: -3.5 (-112) | Buffalo: +3.5 (-108)
• Total: 50.5 -- Over: (-115) | Under: (-105)

UConn vs Buffalo Betting Trends

• UConn has won twice against the spread this year.
• As a 3.5-point or greater favorite, UConn has one win ATS (1-2) this season.
• There have been three UConn games (of four) that went over the total this year.
• Buffalo has posted two wins against the spread this season.
• Buffalo has yet to lose ATS (1-0) as a 3.5-point underdog or greater this year.
• Buffalo has played two games (out of four) which finished over the total this year.

UConn vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Huskies win (61.2%)

UConn vs Buffalo Point Spread

UConn is favored by 3.5 points versus Buffalo. UConn is -112 to cover the spread, while Buffalo is -108.

UConn vs Buffalo Over/Under

An over/under of 50.5 has been set for UConn-Buffalo on Sept. 27, with the over being -115 and the under -105.

UConn vs Buffalo Moneyline

The moneyline numbers for UConn vs. Buffalo reveal UConn as the favorite (-170) and Buffalo as the underdog (+140).

UConn vs. Buffalo Points Insights

UConn vs. Buffalo Game Info

• Game day: Saturday, September 27, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN+
• Location: Buffalo, New York
• Stadium: UB Stadium

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Check out even more in-depth UConn vs. Buffalo analysis on FanDuel Research.