Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 7:11 p.m.

The Minnesota Twins versus the Chicago White Sox is on the MLB schedule for Tuesday.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs White Sox Game Info

• Minnesota Twins (7-15) vs. Chicago White Sox (5-17)
• Date: Tuesday, April 22, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CHSN

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-250) | CHW: (+205)
• Spread: MIN: -1.5 (-120) | CHW: +1.5 (-100)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Bailey Ober (Twins) - 1-1, 6.16 ERA vs Davis Martin (White Sox) - 1-2, 4.84 ERA

The probable starters are Bailey Ober (1-1) for the Twins and Davis Martin (1-2) for the White Sox. Ober's team is 2-2-0 against the spread in his starts this season. Ober's team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 2-2-0 ATS in Martin's four starts with a set spread. The White Sox have a 1-3 record in Martin's four starts this season when they were the underdog on the moneyline.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (70.5%)

Twins vs White Sox Moneyline

• Minnesota is the favorite, -250 on the moneyline, while Chicago is a +205 underdog on the road.

Twins vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Twins. The White Sox are -100 to cover the spread, and the Twins are -120.

Twins vs White Sox Over/Under

• The over/under for Twins-White Sox on April 22 is 8.5. The over is -122, and the under is -100.

Bet on Minnesota Twins vs. Chicago White Sox on FanDuel today!

Twins vs White Sox Betting Trends

• The Twins have been victorious in six, or 40%, of the 15 contests they have been chosen as favorites in this season.
• Oddsmakers have given Minnesota the best odds of winning it has seen this season, with a -250 moneyline listed for this contest.
• The Twins and their opponents have gone over in eight of their 22 games with a total set by sportsbooks this season.
• The Twins are 9-13-0 against the spread in their 22 games that had a posted line this season.
• The White Sox are 5-17 in games they were the underdog on the moneyline (winning 22.7% of those games).
• Chicago is 1-2 (winning just 33.3% of its games) when playing as a moneyline underdog of +205 or longer.
• The White Sox have combined with opponents to hit the over on the total nine times this season for a 9-11-2 record against the over/under.
• The White Sox have covered 50% of their games this season, going 11-11-0 against the spread.

Twins Player Leaders

• Byron Keiron Buxton has 19 hits to go with a slugging percentage of .474, both of which are best among Minnesota hitters this season. He has a .244 batting average and an on-base percentage of .277.
• Among all qualified hitters in the majors, he ranks 82nd in batting average, 125th in on-base percentage, and 49th in slugging.
• Buxton hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .409 with a double, a triple, a home run and three RBI.
• Ty France has 18 hits this season and a team-best OBP of .314. He's batting .234 and slugging .351.
• Among all qualified hitters, he ranks 94th in batting average, 95th in on-base percentage and 118th in slugging percentage.
• Harrison Joseph Bader is batting .250 with a .429 slugging percentage and 12 RBI this year.
• Trevor Larnach is batting .194 with a .298 OBP and five RBI for Minnesota this season.
• Larnach has hit safely in three straight games. During his last five outings he is hitting .176 with a home run, a walk and an RBI.

White Sox Player Leaders

• Andrew Sebastian Benintendi has four home runs and four walks while hitting .245. He's slugging .490 with an on-base percentage of .302.
• Luis Robert is hitting .145 with a double, two home runs and 12 walks. He's slugging .246 with an on-base percentage of .268.
• He is currently 171st in batting average, 137th in on-base percentage and 165th in slugging percentage among all qualified hitters.
• Matt Thaiss is hitting .222 with two doubles, a home run and nine walks.
• Brooks Baldwin is hitting .254 with two doubles, two home runs and a walk.

Twins vs White Sox Head to Head

• 4/2/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/1/2025: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2025: 9-0 CHW (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2024: 13-7 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 8/3/2024: 6-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 8/2/2024: 10-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 7/10/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/10/2024: 3-1 CHW (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/8/2024: 8-6 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/1/2024: 10-5 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)

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