Tigers vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:13 p.m.

The Detroit Tigers versus the Milwaukee Brewers is on the MLB schedule for Wednesday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Brewers Game Info

• Detroit Tigers (12-12) vs. Milwaukee Brewers (13-9)
• Date: Wednesday, April 22, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Brewers.TV

Tigers vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | MIL: (+116)
• Spread: DET: -1.5 (+152) | MIL: +1.5 (-184)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Tigers vs Brewers Probable Starting Pitchers

Probable Pitchers: Casey Mize (Tigers) - 1-1, 2.78 ERA vs D.L. Hall (Brewers) - 0-0, 2.79 ERA

The Tigers will give the nod to Casey Mize (1-1, 2.78 ERA), who is eyeing win No. 2 on the season, and the Brewers will counter with D.L. Hall. Mize and his team have a record of 2-2-0 against the spread when he starts. Mize's team won his only start as a favorite this season. Last season Hall and his team covered the spread in each of their three chances when he pitched. Hall and his team never lost a game he appeared in when they were moneyline underdogs a season ago (in two opportunities).

Tigers vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (52%)

Tigers vs Brewers Moneyline

• Detroit is the favorite, -134 on the moneyline, while Milwaukee is a +116 underdog on the road.

Tigers vs Brewers Spread

• The Brewers are +1.5 on the spread (-184 to cover), and Detroit is +152 to cover the runline.

Tigers vs Brewers Over/Under

• The Tigers-Brewers game on April 22 has been given an over/under of 7.5 runs. The over is set at -124 and the under at +102.

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Tigers vs Brewers Betting Trends

• The Tigers have been chosen as favorites in 15 games this year and have walked away with the win nine times (60%) in those games.
• This year Detroit has won six of 10 games when listed as at least -134 on the moneyline.
• The Tigers and their opponents have gone over in 11 of their 24 games with a total set by sportsbooks this season.
• The Tigers have an against the spread mark of 12-12-0 in 24 games with a line this season.
• The Brewers have a 4-4 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Milwaukee has played as a moneyline underdog of +116 or longer in only two games this season, which it lost both.
• The Brewers have played in 22 games with a set over/under, and have combined with opponents to go over the total 13 times (13-9-0).
• The Brewers have a 14-8-0 record ATS this season (covering 63.6% of the time).

Tigers Player Leaders

• Kevin McGonigle leads Detroit OPS (.904) this season. He has a .322 batting average, an on-base percentage of .410, and a slugging percentage of .494.
• Among the qualifying hitters in baseball, his batting average ranks ninth, his on-base percentage ranks 11th, and he is 35th in slugging.
• McGonigle has recorded a base hit in six straight games. In his last 10 outings he is hitting .368 with three doubles, a triple, a home run, seven walks and three RBIs.
• Dillon Dingler has 19 hits, which is best among Detroit batters this season. He's batting .264 with nine extra-base hits. He's also slugging .528 with an on-base percentage of .346.
• Among qualified hitters, his batting average ranks him 65th, his on-base percentage 68th, and his slugging percentage 24th.
• Riley Greene has 22 hits this season and has a slash line of .265/.378/.386.
• Greene takes a three-game hitting streak into this game. During his last five outings he is batting .308 with a double, five walks and two RBIs.
• Gleyber Torres is batting .244 with a .371 OBP and seven RBI for Detroit this season.
• Torres takes a four-game hitting streak into this matchup. In his last five games he is hitting .222 with four walks and two RBIs.

Brewers Player Leaders

• Brice Turang has a slugging percentage of .560 and has 23 hits, both team-high figures for the Brewers. He's batting .307 and with an on-base percentage of .430.
• He is 16th in batting average, fifth in on-base percentage and 14th in slugging percentage among all qualifying batters in the big leagues.
• Turang hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .316 with a double, a home run, four walks and seven RBIs.
• William Contreras paces his team with a .449 slugging percentage. He has a batting average of .295 with an on-base percentage of .382.
• He is currently 23rd in batting average, 24th in on-base percentage and 58th in slugging percentage among all qualified batters.
• Jake Bauers has two doubles, five home runs and seven walks while hitting .236.
• Gary Sanchez is batting .234 with a double, a triple, five home runs and 13 walks.

Tigers vs Brewers Head to Head

• 4/21/2026: 12-4 MIL (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/16/2025: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/15/2025: 5-0 MIL (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/14/2025: 9-1 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/9/2024: 10-2 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/8/2024: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/7/2024: 10-0 MIL (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2023: 6-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/25/2023: 4-3 DET (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/24/2023: 4-2 DET (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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