Royals vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 9:12 p.m.

The Kansas City Royals versus the Baltimore Orioles is on the MLB schedule for Wednesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Royals vs Orioles Game Info

• Kansas City Royals (7-16) vs. Baltimore Orioles (11-12)
• Date: Wednesday, April 22, 2026
• Time: 2:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and MASN

Royals vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-124) | BAL: (+106)
• Spread: KC: -1.5 (+164) | BAL: +1.5 (-200)
• Total: 9 -- Over: (-122) | Under: (+100)

Royals vs Orioles Probable Starting Pitchers

Probable Pitchers: Michael Wacha (Royals) - 2-0, 1.00 ERA vs Chris Bassitt (Orioles) - 0-2, 6.19 ERA

The Royals will give the ball to Michael Wacha (2-0, 1.00 ERA), who is eyeing win No. 3 on the season, and the Orioles will counter with Chris Bassitt (0-2, 6.19 ERA). When Wacha starts, his team is 2-2-0 against the spread this season. Wacha's team won his only start as a favorite this season. When Bassitt starts, the Orioles have gone 2-2-0 against the spread. The Orioles have a 2-1 record in Bassitt's three starts this season when they were the moneyline underdog.

Royals vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (56.4%)

Royals vs Orioles Moneyline

• The Royals vs Orioles moneyline has Kansas City as a -124 favorite, while Baltimore is a +106 underdog on the road.

Royals vs Orioles Spread

• The Orioles are +1.5 on the spread (-200 to cover), and Kansas City is +164 to cover the runline.

Royals vs Orioles Over/Under

• Royals versus Orioles, on April 22, has an over/under of 9, with the over being -122 and the under +100.

Bet on Kansas City Royals vs. Baltimore Orioles on FanDuel today!

Royals vs Orioles Betting Trends

• The Royals have come away with four wins in the nine contests they have been listed as the favorites in this season.
• Kansas City has a record of 3-3 when favored by -124 or more this year.
• The Royals and their opponents have gone over in seven of their 21 games with a total set by sportsbooks this season.
• The Royals are 8-13-0 against the spread in their 21 games that had a posted line this season.
• The Orioles have been the underdog on the moneyline eight total times this season. They've finished 2-6 in those games.
• Baltimore has a 1-3 record (winning only 25% of its games) when it has played as a moneyline underdog of +106 or longer.
• The Orioles have played in 23 games with an over/under set, and have combined with their opponents to go over the total 13 times (13-10-0).
• The Orioles have a 9-14-0 record ATS this season.

Royals Player Leaders

• Maikel Garcia leads Kansas City in slugging percentage (.402) thanks to eight extra-base hits. He has a .272 batting average and an on-base percentage of .333.
• Among all qualifying hitters in MLB, he ranks 55th in batting average, 83rd in on-base percentage, and 85th in slugging.
• Bobby Witt Jr. is slashing .287/.370/.356 this season and leads the Royals with an OPS of .726.
• Among qualified hitters, he ranks 37th in batting average, 42nd in on-base percentage and 122nd in slugging percentage.
• Witt brings a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .400 with three doubles, two walks and two RBIs.
• Carter Jensen leads Kansas City with 15 hits. He is batting .238 this season and six of his hits have gone for extra bases.
• Jensen enters this matchup with two games in a row with at least one hit. In his last five games he is batting .278 with a home run, three walks and three RBIs.
• Vinnie Pasquantino has two home runs, 11 RBI and a batting average of .149 this season.

Orioles Player Leaders

• Taylor Ward has a team-high OBP (.394) and slugging percentage (.457). He's batting .293.
• He is 30th in batting average, 17th in on-base percentage and 59th in slugging percentage among all qualified hitters in the big leagues.
• Ward heads into this matchup on a three-game hitting streak. During his last five outings he is batting .263 with two doubles, a home run, five walks and three RBIs.
• Gunnar Henderson is hitting .196 with three doubles, a triple, seven home runs and 11 walks. He's slugging .464 with an on-base percentage of .282.
• Including all qualified hitters, he ranks 156th in batting average, 146th in on-base percentage and 54th in slugging percentage.
• Jeremiah Jackson has racked up 21 hits, a team-high for the Orioles.
• Leody Taveras is hitting .341 with three doubles, two home runs and nine walks.

Royals vs Orioles Head to Head

• 4/20/2026: 7-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2025: 11-6 KC (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/3/2025: 4-0 KC (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/2/2025: 3-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 8-1 BAL (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 8-2 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 10/2/2024: 2-1 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 10/1/2024: 1-0 KC (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/21/2024: 5-0 BAL (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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