Royals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 7

Odds updated as of 1:11 p.m.

The Kansas City Royals are among the MLB squads in action on Thursday, up against the Cleveland Guardians.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Royals vs Guardians Game Info

• Kansas City Royals (17-20) vs. Cleveland Guardians (19-19)
• Date: Thursday, May 7, 2026
• Time: 2:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Royals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-144) | CLE: (+122)
• Spread: KC: -1.5 (+132) | CLE: +1.5 (-160)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Royals vs Guardians Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 1-1, 2.68 ERA vs Slade Cecconi (Guardians) - 1-4, 6.56 ERA

The Royals will give the nod to Seth Lugo (1-1) versus the Guardians and Slade Cecconi (1-4). Lugo and his team have a record of 5-2-0 against the spread when he starts. Lugo's team is 2-1 this season when he starts and they are the moneyline favorite. The Guardians have a 2-5-0 record against the spread in Cecconi's starts. The Guardians have been the moneyline underdog in six of Cecconi's starts this season, and they went 1-5 in those games.

Royals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (60%)

Royals vs Guardians Moneyline

• Kansas City is the favorite, -144 on the moneyline, while Cleveland is a +122 underdog on the road.

Royals vs Guardians Spread

• The Guardians are +1.5 on the run line against the Royals. The Guardians are -160 to cover, and the Royals are +132.

Royals vs Guardians Over/Under

• A combined run total of 9.5 has been set for Royals-Guardians on May 7, with the over at -110 and the under at -110.

Bet on Kansas City Royals vs. Cleveland Guardians on FanDuel today!

Royals vs Guardians Betting Trends

• The Royals have won in nine, or 56.2%, of the 16 contests they have been named as odds-on favorites in this year.
• This season Kansas City has been victorious three times in five chances when named as a favorite of at least -144 on the moneyline.
• Contests with the Royals have gone over the total set by oddsmakers in 14 of 35 chances this season.
• The Royals are 17-18-0 against the spread in their 35 games with a line set by sportsbooks this season.
• The Guardians have a 10-10 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Cleveland has a record of 4-4 in games it has played as a moneyline underdog with odds of +122 or longer (50%).
• The Guardians have combined with opponents to go over the total 18 times this season for an 18-19-0 record against the over/under.
• The Guardians have collected a 19-18-0 record against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. leads Kansas City with a slugging percentage of .422, fueled by 14 extra-base hits. He has a .279 batting average and an on-base percentage of .349.
• Among all qualifying hitters, he is 40th in batting average, his on-base percentage ranks 65th, and he is 69th in slugging.
• Maikel Garcia is hitting .265 with nine doubles, a triple, three home runs and 15 walks. He's slugging .412 with an on-base percentage of .333.
• He is 59th in batting average, 86th in on-base percentage and 78th in slugging in the major leagues.
• Vinnie Pasquantino has collected 25 base hits, an OBP of .280 and a slugging percentage of .349 this season.
• Salvador Perez has been key for Kansas City with 29 hits, an OBP of .245 plus a slugging percentage of .348.

Guardians Player Leaders

• Jose Ramirez is batting .209 with eight doubles, six home runs and 26 walks. He's slugging .396 with an on-base percentage of .333.
• Including all the qualified hitters in MLB, he ranks 148th in batting average, 86th in on-base percentage and 95th in slugging percentage.
• Chase DeLauter's 37 hits, .391 OBP and .550 slugging percentage all lead his team. He has a batting average of .308.
• Including all qualifying hitters, he ranks 19th in batting average, 16th in on-base percentage and 16th in slugging percentage.
• Brayan Rocchio is hitting .254 with four doubles, three home runs and 12 walks.
• Angel Martinez has seven doubles, five home runs and five walks while hitting .270.

Royals vs Guardians Head to Head

• 5/6/2026: 3-1 CLE (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/11/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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