Royals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 7:11 p.m.

The MLB's Wednesday schedule includes the Kansas City Royals taking on the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Royals vs Guardians Game Info

• Kansas City Royals (17-19) vs. Cleveland Guardians (18-19)
• Date: Wednesday, May 6, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Royals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-134) | CLE: (+116)
• Spread: KC: -1.5 (+158) | CLE: +1.5 (-192)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Royals vs Guardians Probable Starting Pitchers

Probable Pitchers: Cole Ragans (Royals) - 1-4, 5.29 ERA vs Joey Cantillo (Guardians) - 1-1, 3.67 ERA

The probable starters are Cole Ragans (1-4) for the Royals and Joey Cantillo (1-1) for the Guardians. Ragans' team is 2-4-0 against the spread this season in his starts. Ragans' team has won 33.3% of his starts when they are favored on the moneyline (1-2). The Guardians have gone 5-2-0 against the spread when Cantillo starts. The Guardians have been the underdog on the moneyline in four of Cantillo's starts this season, and they went 3-1 in those matchups.

Royals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (53.9%)

Royals vs Guardians Moneyline

• Looking at the moneyline for Guardians-Royals, Cleveland is the underdog at +116, and Kansas City is -134 playing at home.

Royals vs Guardians Spread

• The Guardians are at the Royals, and are +1.5 on the runline. The Guardians are +158 to cover the spread, and the Royals are -192.

Royals vs Guardians Over/Under

• A total of 7.5 runs has been set for the Royals-Guardians contest on May 6, with the over available at -104 and the under at -118.

Bet on Kansas City Royals vs. Cleveland Guardians on FanDuel today!

Royals vs Guardians Betting Trends

• The Royals have been favorites in 15 games this season and have come away with the win nine times (60%) in those contests.
• This season Kansas City has been victorious four times in seven chances when named as a favorite of at least -134 on the moneyline.
• The Royals and their opponents have gone over in 14 of their 34 games with a total set by sportsbooks this season.
• The Royals have posted a record of 17-17-0 against the spread this season.
• The Guardians have put together a 9-10 record in games they were listed as the moneyline underdog (winning 47.4% of those games).
• Cleveland has gone 5-6 when it has played as a moneyline underdog with odds of +116 or longer (45.5%).
• The Guardians have combined with opponents to hit the over on the total 18 times this season for an 18-18-0 record against the over/under.
• The Guardians have collected an 18-18-0 record against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. has 41 hits to go with a slugging percentage of .434, both of which lead Kansas City hitters this season. He has a .287 batting average and an on-base percentage of .358.
• Among qualified batters in baseball, his batting average ranks 35th, his on-base percentage ranks 54th, and he is 63rd in slugging.
• Witt has picked up at least one hit in five straight games. In his last five games he is batting .273 with a double, a home run, a walk and an RBI.
• Maikel Garcia is batting .256 with nine doubles, a triple, three home runs and 14 walks. He's slugging .406 with an on-base percentage of .322.
• His batting average ranks 77th among qualified players, his on-base percentage 104th, and his slugging percentage 84th.
• Vinnie Pasquantino is batting .192 with a .352 slugging percentage and 18 RBI this year.
• Salvador Perez has five home runs, 16 RBI and a batting average of .209 this season.
• Perez has hit safely in two straight games. In his last five games he is hitting .263 with two doubles and five RBIs.

Guardians Player Leaders

• Jose Ramirez has eight doubles, six home runs and 24 walks while hitting .212. He's slugging .401 with an on-base percentage of .329.
• Including all qualified hitters, he is 144th in batting average, while his on-base percentage ranks 93rd and he is 87th in slugging.
• Chase DeLauter's 35 hits, .388 OBP and .543 slugging percentage all lead his team. He has a batting average of .302.
• He is 28th in batting average, 23rd in on-base percentage and 17th in slugging percentage in the big leagues.
• Brayan Rocchio is hitting .261 with four doubles, three home runs and 11 walks.
• Angel Martinez has seven doubles, five home runs and four walks while batting .271.

Royals vs Guardians Head to Head

• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/11/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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