Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 12:12 p.m.

The Cincinnati Reds versus the Pittsburgh Pirates is on the MLB schedule for Thursday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Pirates Game Info

• Cincinnati Reds (80-78) vs. Pittsburgh Pirates (69-89)
• Date: Thursday, September 25, 2025
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and SportsNet PT

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-172) | PIT: (+144)
• Spread: CIN: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 8 -- Over: (-108) | Under: (-112)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Nick Lodolo (Reds) - 8-8, 3.44 ERA vs Braxton Ashcraft (Pirates) - 4-3, 2.62 ERA

This contest's pitching matchup is set, as the Reds will send Nick Lodolo (8-8) to the mound, while Braxton Ashcraft (4-3) will answer the bell for the Pirates. Lodolo and his team have a record of 14-11-0 against the spread when he starts. Lodolo's team has a record of 6-5 this season when he starts and they are the favorite on the moneyline. The Pirates are 5-2-0 against the spread when Ashcraft starts. The Pirates have a 3-2 record in Ashcraft's five starts this season when they were the underdog on the moneyline.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (57.6%)

Reds vs Pirates Moneyline

• The Reds vs Pirates moneyline has Cincinnati as a -172 favorite, while Pittsburgh is a +144 underdog on the road.

Reds vs Pirates Spread

• The Reds are hosting the Pirates and are favored by 1.5 runs (+126 to cover) on the runline. Pittsburgh is -152 to cover.

Reds vs Pirates Over/Under

• A total of 8 runs has been set for the Reds-Pirates contest on Sept. 25, with the over available at -108 and the under at -112.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have been favorites in 65 games this season and have come away with the win 34 times (52.3%) in those contests.
• Cincinnati has a record of 5-4 when favored by -172 or more this year.
• The Reds' games have gone over the total in 58 of their 150 opportunities.
• The Reds have posted a record of 78-72-0 against the spread this season.
• The Pirates have gone 43-61 in games they were the underdog on the moneyline (winning 41.3% of those games).
• Pittsburgh has gone 12-20 in games it has played as a moneyline underdog with odds of +144 or longer (37.5%).
• In the 150 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 57 times (57-86-7).
• The Pirates have covered 54% of their games this season, going 81-69-0 ATS.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.442) and total hits (163) this season. He's batting .266 with an on-base percentage of .339.
• He is 49th in batting average, 54th in on-base percentage, and 61st in slugging among all qualified hitters in MLB.
• De La Cruz has picked up at least one hit in five straight games. In his last five games he is hitting .438 with a double, two home runs, four walks and three RBIs.
• TJ Friedl has 145 hits this season and a team-best OBP of .360. He's batting .257 and slugging .369.
• Among qualified hitters, his batting average ranks him 76th, his on-base percentage 20th, and his slugging percentage 133rd.
• Friedl enters this game looking to extend his two-game hit streak. During his last five outings he is batting .250 with a home run, two walks and two RBIs.
• Spencer Steer has 119 hits this season and has a slash line of .240/.313/.416.
• Austin Hays is batting .266 with a .316 OBP and 64 RBI for Cincinnati this season.

Pirates Player Leaders

• Bryan Reynolds has 139 hits with a .402 slugging percentage, both team-high marks for the Pirates. He's batting .243 and with an on-base percentage of .318.
• Including all the qualified hitters in MLB, he is 107th in batting average, 96th in on-base percentage and 97th in slugging percentage.
• Andrew McCutchen's .335 OBP leads his team. He has a batting average of .240 while slugging .370.
• His batting average ranks 113th among all qualified players, his on-base percentage is 60th, and he is 131st in slugging.
• Oneil Cruz is hitting .201 with 18 doubles, three triples, 20 home runs and 64 walks.
• Spencer Horwitz is hitting .262 with 25 doubles, nine home runs and 41 walks.

Reds vs Pirates Head to Head

• 9/24/2025: 4-3 PIT (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/23/2025: 4-2 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)

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