Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 11:12 a.m.

MLB action on Tuesday includes the Cincinnati Reds facing the Pittsburgh Pirates.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Pirates Game Info

• Cincinnati Reds (80-76) vs. Pittsburgh Pirates (67-89)
• Date: Tuesday, September 23, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SportsNet PT

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-158) | PIT: (+134)
• Spread: CIN: -1.5 (+130) | PIT: +1.5 (-156)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 14-10, 3.86 ERA vs Johan Oviedo (Pirates) - 2-0, 3.52 ERA

The probable pitchers are Brady Singer (14-10) for the Reds and Johan Oviedo (2-0) for the Pirates. Singer's team is 17-11-0 against the spread in his starts this season. When Singer starts a game and his team is the favorite on the moneyline, they have a record of 7-5. The Pirates have a 5-2-0 ATS record in Oviedo's seven starts with a set spread. The Pirates have a 3-4 record in Oviedo's seven starts this season when they were the moneyline underdog.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (62.8%)

Reds vs Pirates Moneyline

• Pittsburgh is the underdog, +134 on the moneyline, while Cincinnati is a -158 favorite at home.

Reds vs Pirates Spread

• The Pirates are at the Reds, and are +1.5 on the runline. The Pirates are +130 to cover the spread, and the Reds are -156.

Reds vs Pirates Over/Under

• The over/under for Reds-Pirates on Sept. 23 is 8.5. The over is -110, and the under is -110.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have won in 34, or 54%, of the 63 contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 8-4 when favored by -158 or more this year.
• The Reds and their opponents have hit the over in 58 of their 148 games with a total set by oddsmakers this season.
• The Reds are 77-71-0 against the spread in their 148 games that had a posted line this season.
• The Pirates have won 41 of the 102 games they were the moneyline underdog this season (40.2%).
• Pittsburgh is 18-28 (winning just 39.1% of its games) when it has played as a moneyline underdog of +134 or longer.
• The Pirates have combined with opponents to go over the total 57 times this season for a 57-85-6 record against the over/under.
• The Pirates are 80-68-0 against the spread this season.

Reds Player Leaders

• Elly De La Cruz has 159 hits to go with a slugging percentage of .436, both of which are tops among Cincinnati hitters this season. He has a .263 batting average and an on-base percentage of .336.
• He is 56th in batting average, 55th in on-base percentage, and 67th in slugging among all qualifying batters in baseball.
• De La Cruz has recorded a base hit in three straight games. In his last five games he is hitting .214 with a double, a home run, four walks and an RBI.
• TJ Friedl leads Cincinnati with an OBP of .360 this season while batting .257 with 76 walks and 79 runs scored. He's slugging .371.
• He is 75th in batting average, 19th in on-base percentage and 133rd in slugging among qualified hitters.
• Spencer Steer is batting .241 with a .419 slugging percentage and 74 RBI this year.
• Austin Hays has 15 home runs, 64 RBI and a batting average of .266 this season.

Pirates Player Leaders

• Bryan Reynolds has put up a team-high slugging percentage (.403) and leads the Pirates in hits (138). He's batting .244 and with an on-base percentage of .316.
• Including all qualifying hitters, he ranks 100th in batting average, while his on-base percentage ranks 99th and he is 94th in slugging.
• Reynolds hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .313 with a double, a home run, four walks and two RBIs.
• Andrew McCutchen's .336 on-base percentage leads his team. He has a batting average of .240 while slugging .372.
• Including all qualified hitters, his batting average puts him 112th, his on-base percentage is 55th, and he is 131st in slugging.
• Oneil Cruz has 18 doubles, three triples, 19 home runs and 64 walks while hitting .203.
• Spencer Horwitz has 23 doubles, nine home runs and 41 walks while hitting .257.

Reds vs Pirates Head to Head

• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/11/2025: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

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