Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 6:13 p.m.

Tuesday's slate in the MLB includes a matchup between the Cincinnati Reds and the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Pirates Game Info

• Cincinnati Reds (80-76) vs. Pittsburgh Pirates (67-89)
• Date: Tuesday, September 23, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SportsNet PT

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-172) | PIT: (+144)
• Spread: CIN: -1.5 (+125) | PIT: +1.5 (-150)
• Total: 8 -- Over: (-108) | Under: (-112)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 14-10, 3.86 ERA vs Johan Oviedo (Pirates) - 2-0, 3.52 ERA

This contest's pitching matchup is set, as the Reds will send Brady Singer (14-10) to the mound, while Johan Oviedo (2-0) will get the nod for the Pirates. Singer and his team are 17-11-0 ATS this season when he starts. Singer's team has a record of 7-5 this season when he starts and they are the favorite on the moneyline. The Pirates are 5-2-0 against the spread when Oviedo starts. The Pirates are 3-4 in Oviedo's seven starts this season that they were the moneyline underdog.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (62.8%)

Reds vs Pirates Moneyline

• Pittsburgh is the underdog, +144 on the moneyline, while Cincinnati is a -172 favorite at home.

Reds vs Pirates Spread

• The Pirates are at the Reds, and are +1.5 on the runline. The Pirates are +125 to cover the spread, and the Reds are -150.

Reds vs Pirates Over/Under

• The over/under for Reds-Pirates on Sept. 23 is 8. The over is -108, and the under is -112.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have won in 34, or 54%, of the 63 contests they have been named as odds-on favorites in this year.
• This year Cincinnati has won five of eight games when listed as at least -172 on the moneyline.
• The Reds and their opponents have gone over the total this season in 58 of their 148 opportunities.
• The Reds are 77-71-0 against the spread in their 148 games with a line set by sportsbooks this season.
• The Pirates are 41-61 in games they were the underdog on the moneyline (winning 40.2% of those games).
• Pittsburgh has a record of 12-20 in games it has played as a moneyline underdog with odds of +144 or longer (37.5%).
• The Pirates have had an over/under set by oddsmakers 148 times, and have combined with opponents to go over the total in 57 of those games (57-85-6).
• The Pirates have an 80-68-0 record ATS this season (covering 54.1% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.436) and total hits (159) this season. He's batting .263 with an on-base percentage of .336.
• Among all qualifying hitters, he is 56th in batting average, his on-base percentage ranks 55th, and he is 67th in slugging.
• De La Cruz will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .214 with a double, a home run, four walks and an RBI.
• TJ Friedl leads Cincinnati in OBP (.360) this season, fueled by 143 hits. He's batting .257 while slugging .371.
• Among all qualifying hitters, he ranks 75th in batting average, 19th in on-base percentage and 133rd in slugging percentage.
• Spencer Steer is batting .241 with a .419 slugging percentage and 74 RBI this year.
• Austin Hays has been key for Cincinnati with 101 hits, an OBP of .316 plus a slugging percentage of .454.

Pirates Player Leaders

• Bryan Reynolds has racked up 138 hits with a .403 slugging percentage, both team-best statistics for the Pirates. He's batting .244 and with an on-base percentage of .316.
• Including all qualifying hitters, he ranks 100th in batting average, while his on-base percentage is 99th and he is 94th in slugging.
• Reynolds heads into this matchup on a three-game hitting streak. During his last five outings he is batting .313 with a double, a home run, four walks and two RBIs.
• Andrew McCutchen leads his team with a .336 on-base percentage. He has a batting average of .240 while slugging .372.
• He is currently 112th in batting average, 55th in on-base percentage and 131st in slugging percentage among all qualified batters.
• Oneil Cruz has 18 doubles, three triples, 19 home runs and 64 walks while hitting .203.
• Spencer Horwitz has 23 doubles, nine home runs and 41 walks while hitting .257.

Reds vs Pirates Head to Head

• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/11/2025: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!