Reds vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 28

Odds updated as of 2:12 a.m.

The MLB slate on Saturday includes the Cincinnati Reds facing the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Padres Game Info

• Cincinnati Reds (43-39) vs. San Diego Padres (44-37)
• Date: Saturday, June 28, 2025
• Time: 4:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SDPA

Reds vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-156) | SD: (+132)
• Spread: CIN: -1.5 (+122) | SD: +1.5 (-146)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Reds vs Padres Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 7-1, 1.79 ERA vs Randy Vasquez (Padres) - 3-4, 3.60 ERA

This contest's pitching matchup is set, as the Reds will send Andrew Abbott (7-1) to the mound, while Randy Vasquez (3-4) will answer the bell for the Padres. Abbott and his team have a record of 8-4-0 against the spread when he starts. Abbott's team has been victorious in 85.7% of the games he's started as the moneyline favorite with a record of 6-1. The Padres have gone 8-7-0 ATS in Vasquez's 15 starts with a set spread. The Padres have been the moneyline underdog in 10 of Vasquez's starts this season, and they went 3-7 in those games.

Reds vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.1%)

Reds vs Padres Moneyline

• The moneyline numbers for Reds vs. Padres reveal Cincinnati as the favorite (-156) and San Diego as the underdog (+132) on the road.

Reds vs Padres Spread

• The Padres are +1.5 on the run line against the Reds. The Padres are -146 to cover, and the Reds are +122.

Reds vs Padres Over/Under

• Reds versus Padres on June 28 has an over/under of 9.5 runs, with the odds on the over -100 and the under set at -122.

Bet on Cincinnati Reds vs. San Diego Padres on FanDuel today!

Reds vs Padres Betting Trends

• The Reds have been chosen as favorites in 31 games this year and have walked away with the win 16 times (51.6%) in those games.
• This season Cincinnati has been victorious five times in seven chances when named as a favorite of at least -156 on the moneyline.
• The Reds and their opponents have hit the over in 34 of their 78 games with a total set by oddsmakers this season.
• The Reds have an against the spread mark of 42-36-0 in 78 games with a line this season.
• The Padres have won 16 of the 36 games they were the moneyline underdog this season (44.4%).
• San Diego is 6-9 (winning 40% of its games) when it has played as a moneyline underdog of +132 or longer.
• The Padres have had an over/under set by bookmakers 80 times, and have combined with opponents to go over the total in 33 of those games (33-44-3).
• The Padres have a 42-38-0 record against the spread this season (covering 52.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.511) and total hits (88) this season. He's batting .279 with an on-base percentage of .352.
• Among all qualified hitters, he ranks 42nd in batting average, his on-base percentage ranks 49th, and he is 19th in slugging.
• De La Cruz hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is hitting .325 with a double, two triples, two home runs, two walks and six RBIs.
• TJ Friedl leads Cincinnati with an OBP of .371 this season while batting .284 with 39 walks and 48 runs scored. He's slugging .421.
• His batting average ranks 30th among qualified players, his on-base percentage 22nd, and his slugging percentage 83rd.
• Spencer Steer is batting .250 with a .402 slugging percentage and 31 RBI this year.
• Steer brings a six-game hitting streak into this matchup. During his last 10 games he is batting .410 with three doubles, a triple, four home runs and nine RBIs.
• Gavin Lux is batting .266 with a .353 OBP and 36 RBI for Cincinnati this season.
• Lux takes a three-game hitting streak into this matchup. During his last five outings he is batting .200 with a home run, a walk and five RBIs.

Padres Player Leaders

• Manny Machado has 91 hits with a .357 on-base percentage and a .487 slugging percentage, all club-bests for the Padres. He's batting .295.
• Including all the qualifying hitters in MLB, he ranks 19th in batting average, 40th in on-base percentage and 30th in slugging percentage.
• Fernando Tatis Jr. is hitting .258 with 11 doubles, a triple, 15 home runs and 38 walks. He's slugging .450 with an on-base percentage of .348.
• His batting average is 77th among all qualified players, his on-base percentage is 53rd, and he is 57th in slugging.
• Luis Arraez has 16 doubles, four triples, three home runs and 13 walks while batting .284.
• Gavin Sheets has 12 doubles, a triple, 12 home runs and 22 walks while batting .259.

Reds vs Padres Head to Head

• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/1/2023: 12-5 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/30/2023: 7-5 CIN (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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