Astros vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 28

Odds updated as of 4:13 a.m.

MLB action on Saturday includes the Houston Astros playing the Chicago Cubs.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Cubs Game Info

• Houston Astros (49-33) vs. Chicago Cubs (48-34)
• Date: Saturday, June 28, 2025
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-124) | CHC: (+106)
• Spread: HOU: -1.5 (+158) | CHC: +1.5 (-192)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Astros vs Cubs Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 1-2, 4.91 ERA vs Colin Rea (Cubs) - 4-3, 4.42 ERA

The probable pitchers are Lance McCullers (1-2) for the Astros and Colin Rea (4-3) for the Cubs. McCullers' team is 4-3-0 against the spread this season in his starts. When McCullers starts a game and his team is the favorite on the moneyline, they have a record of 1-3. The Cubs have a 6-5-0 record against the spread in Rea's starts. The Cubs have a 3-1 record in Rea's four starts this season when they were the moneyline underdog.

Astros vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.5%)

Astros vs Cubs Moneyline

• The Astros vs Cubs moneyline has Houston as a -124 favorite, while Chicago is a +106 underdog on the road.

Astros vs Cubs Spread

• The Astros are hosting the Cubs and are favored by 1.5 runs on the spread. The Astros are +158 to cover the runline, with the Cubs being -192.

Astros vs Cubs Over/Under

• A combined run total of 8.5 has been set for Astros-Cubs on June 28, with the over at -122 and the under at -100.

Bet on Houston Astros vs. Chicago Cubs on FanDuel today!

Astros vs Cubs Betting Trends

• The Astros have been chosen as favorites in 56 games this year and have walked away with the win 34 times (60.7%) in those games.
• This year Houston has won 23 of 37 games when listed as at least -124 on the moneyline.
• The Astros and their opponents have hit the over in 32 of their 81 games with a total set by oddsmakers this season.
• In 81 games with a line this season, the Astros have a mark of 42-39-0 against the spread.
• The Cubs are 9-16 in games they were listed as the moneyline underdog (winning 36% of those games).
• Chicago has gone 5-10 when playing as a moneyline underdog with odds of +106 or longer (33.3%).
• The Cubs have played in 80 games with a set over/under, and have combined with opponents to go over the total 43 times (43-33-4).
• The Cubs have a 40-40-0 record against the spread this season (covering 50% of the time).

Astros Player Leaders

• Jeremy Pena has 102 hits and an OBP of .378 to go with a slugging percentage of .489. All three of those stats rank first among Houston hitters this season. He has a .322 batting average, as well.
• Among all qualified hitters in the majors, his batting average ranks fourth, his on-base percentage ranks 16th, and he is 29th in slugging.
• Isaac Paredes is batting .253 with 10 doubles, a triple, 16 home runs and 42 walks, while slugging .462 with an on-base percentage of .358.
• His batting average is 90th among qualified players, his on-base percentage 36th, and his slugging percentage 51st.
• Jose Altuve has collected 80 base hits, an OBP of .322 and a slugging percentage of .414 this season.
• Altuve has logged a hit or more in two straight games. During his last five outings he is hitting .167 with three walks.
• Jake Meyers has been key for Houston with 80 hits, an OBP of .365 plus a slugging percentage of .398.
• Meyers enters this game on a three-game hitting streak. In his last five games he is batting .294 with a walk and an RBI.

Cubs Player Leaders

• Kyle Tucker has a team-best .391 on-base percentage. He's batting .283 and slugging .520.
• He ranks 34th in batting average, eighth in on-base percentage and 14th in slugging percentage among all qualified hitters in the big leagues.
• Pete Crow-Armstrong has 85 hits to pace his team. He has a batting average of .268 while slugging .549 with an on-base percentage of .304.
• He is 60th in batting average, 121st in on-base percentage and eighth in slugging percentage in MLB.
• Seiya Suzuki is batting .259 with 19 doubles, two triples, 21 home runs and 28 walks.
• Nico Hoerner is slugging .378 to lead his team.

Astros vs Cubs Head to Head

• 6/27/2025: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/25/2024: 3-1 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/24/2024: 4-3 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/23/2024: 7-2 CHC (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/17/2023: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/16/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/15/2023: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!