Guardians vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for June 28

Odds updated as of 4:13 a.m.

On Saturday in MLB, the Cleveland Guardians are up against the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Cardinals Game Info

• Cleveland Guardians (40-40) vs. St. Louis Cardinals (45-38)
• Date: Saturday, June 28, 2025
• Time: 4:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSMW

Guardians vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | STL: (-100)
• Spread: CLE: +1.5 (-196) | STL: -1.5 (+162)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Guardians vs Cardinals Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 3-3, 3.38 ERA vs Miles Mikolas (Cardinals) - 4-5, 4.31 ERA

This contest's pitching matchup is set, as the Guardians will send Slade Cecconi (3-3) to the mound, while Miles Mikolas (4-5) will get the nod for the Cardinals. When Cecconi starts, his team is 5-2-0 against the spread this season. When Cecconi starts a game and his team is the favorite on the moneyline, they have a record of 2-1. The Cardinals are 7-8-0 against the spread when Mikolas starts. The Cardinals have a 5-6 record in Mikolas' 11 starts this season when they were the moneyline underdog.

Guardians vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.5%)

Guardians vs Cardinals Moneyline

• Cleveland is a -118 favorite on the moneyline, while St. Louis is a -100 underdog on the road.

Guardians vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Guardians. The Cardinals are +162 to cover, while the Guardians are -196 to cover as a 1.5-run underdog on the runline.

Guardians vs Cardinals Over/Under

• A combined run total of 8.5 has been set for Guardians-Cardinals on June 28, with the over at -106 and the under at -114.

Bet on Cleveland Guardians vs. St. Louis Cardinals on FanDuel today!

Guardians vs Cardinals Betting Trends

• The Guardians have been victorious in 17, or 60.7%, of the 28 contests they have been chosen as favorites in this season.
• Cleveland has a record of 14-9 when favored by -118 or more this year.
• The Guardians' games have gone over the total in 33 of their 78 opportunities.
• The Guardians are 38-40-0 against the spread in their 78 games with a line set by sportsbooks this season.
• The Cardinals have compiled a 24-22 record in games they were the underdog on the moneyline (winning 52.2% of those games).
• When it has played as a moneyline underdog with odds of -100 or longer, St. Louis has a record of 13-19 (40.6%).
• The Cardinals have played in 83 games with a set over/under, and have combined with their opponents to go over the total 43 times (43-37-3).
• The Cardinals have a 45-38-0 record against the spread this season (covering 54.2% of the time).

Guardians Player Leaders

• Jose Ramirez has 92 hits and an OBP of .378 to go with a slugging percentage of .514. All three of those stats rank first among Cleveland hitters this season. He has a .317 batting average, as well.
• Among qualified hitters in baseball, he ranks sixth in batting average, 16th in on-base percentage, and 15th in slugging.
• Steven Kwan has 18 doubles, six home runs and 28 walks. He's batting .302 and slugging .423 with an on-base percentage of .366.
• Among qualified hitters, his batting average places him 13th, his on-base percentage 26th, and his slugging percentage 80th.
• Carlos Santana has collected 61 base hits, an OBP of .328 and a slugging percentage of .360 this season.
• Kyle Manzardo has 12 home runs, 32 RBI and a batting average of .219 this season.

Cardinals Player Leaders

• Nolan Arenado is hitting .246 with 12 doubles, a triple, 10 home runs and 24 walks. He's slugging .396 with an on-base percentage of .307.
• Including all the qualified hitters in the big leagues, his batting average places him 107th, his on-base percentage is 117th, and he is 108th in slugging.
• Brendan Donovan leads his team with a .368 OBP, and has a club-leading .423 slugging percentage. He has a batting average of .300.
• He is currently 15th in batting average, 23rd in on-base percentage and 80th in slugging percentage among all qualifying batters.
• Lars Nootbaar is hitting .228 with 13 doubles, 11 home runs and 45 walks.
• Alec Burleson has racked up 73 hits to lead his team.

Guardians vs Cardinals Head to Head

• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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