Reds vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for July 27

Odds updated as of 1:11 p.m.

In MLB action on Tuesday, the Cincinnati Reds play the Cleveland Guardians.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Reds vs Guardians Game Info

• Cincinnati Reds (49-55) vs. Cleveland Guardians (54-53)
• Date: Tuesday, July 28, 2026
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and CleGuardians.TV

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-162) | CLE: (+136)
• Spread: CIN: -1.5 (+120) | CLE: +1.5 (-144)
• Total: 9 -- Over: (-110) | Under: (-110)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 12-1, 2.42 ERA vs Slade Cecconi (Guardians) - 4-7, 4.60 ERA

The Reds will give the nod to Chase Burns (12-1) versus the Guardians and Slade Cecconi (4-7). Burns and his team are 15-4-0 ATS this season when he starts. Burns' team has been victorious in 76.9% of the games he's started as the moneyline favorite with a record of 10-3. When Cecconi starts, the Guardians have gone 9-9-0 against the spread. The Guardians have been the moneyline underdog in 13 of Cecconi's starts this season, and they went 3-10 in those matchups.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (59.8%)

Reds vs Guardians Moneyline

• Looking at the moneyline for Guardians-Reds, Cleveland is the underdog at +136, and Cincinnati is -162 playing at home.

Reds vs Guardians Spread

• The Guardians are +1.5 on the run line against the Reds. The Guardians are -144 to cover, and the Reds are +120.

Reds vs Guardians Over/Under

• The over/under for Reds-Guardians on July 28 is 9. The over is -110, and the under is -110.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have been favorites in 31 games this season and have come away with the win 16 times (51.6%) in those contests.
• This season Cincinnati has been victorious four times in six chances when named as a favorite of at least -162 on the moneyline.
• The Reds' games have gone over the total in 55 of their 102 opportunities.
• The Reds have an against the spread record of 56-46-0 in 102 games with a line this season.
• The Guardians have been the underdog on the moneyline 47 total times this season. They've gone 24-23 in those games.
• Cleveland has a 6-4 record (winning 60% of its games) when it has played as a moneyline underdog of +136 or longer.
• The Guardians have had an over/under set by bookmakers 101 times, and have combined with opponents to go over the total in 48 of those games (48-53-0).
• The Guardians have covered 48.5% of their games this season, going 49-52-0 ATS.

Reds Player Leaders

• Sal Stewart leads Cincinnati in slugging percentage (.470) thanks to 44 extra-base hits. He has a .253 batting average and an on-base percentage of .329.
• Among all qualifying hitters in MLB, his batting average ranks 78th, his on-base percentage ranks 78th, and he is 38th in slugging.
• Stewart hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .294 with a home run and six RBIs.
• Elly De La Cruz leads the Reds in OBP (.354) and total hits (94) this season. He's batting .278 while slugging .506.
• Among qualifying batters, he is 35th in batting average, 39th in on-base percentage and 17th in slugging percentage.
• De La Cruz has picked up at least one hit in three games in a row. In his last five games he is hitting .263 with two home runs, four walks and two RBIs.
• JJ Bleday has 64 hits this season and has a slash line of .234/.343/.469.
• Nathaniel Lowe has been key for Cincinnati with 57 hits, an OBP of .333 plus a slugging percentage of .475.
• Lowe has safely hit in two games in a row. In his last five games he is hitting .304 with two home runs and six RBIs.

Guardians Player Leaders

• Chase DeLauter has 94 hits with a .352 on-base percentage, leading the Guardians in both statistics. He's batting .282 and slugging .447.
• He is 25th in batting average, 43rd in on-base percentage and 57th in slugging percentage among all qualified batters in MLB.
• Brayan Rocchio is slugging .398 to lead his team. He has a batting average of .268 with an on-base percentage of .328.
• His batting average is 51st among all qualified players, his on-base percentage ranks 80th, and he is 102nd in slugging.
• Jose Ramirez has 18 doubles, 10 home runs and 43 walks while batting .236.
• Steven Kwan is batting .248 with 13 doubles, two triples, a home run and 51 walks.

Reds vs Guardians Head to Head

• 5/17/2026: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/16/2026: 7-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!