Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 27

Odds updated as of 7:12 p.m.

In MLB action on Monday, the Chicago Cubs play the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Cardinals Game Info

• Chicago Cubs (59-46) vs. St. Louis Cardinals (53-52)
• Date: Monday, July 27, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-122) | STL: (+104)
• Spread: CHC: -1.5 (+126) | STL: +1.5 (-152)
• Total: 9.5 -- Over: (-106) | Under: (-114)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: David Peterson (Cubs) - 5-7, 5.97 ERA vs Matthew Liberatore (Cardinals) - 5-7, 5.18 ERA

The Cubs will call on David Peterson (5-7) against the Cardinals and Matthew Liberatore (5-7). When Peterson starts, his team is 4-8-0 against the spread this season. When Peterson starts a game and his team is the favorite on the moneyline, they have a record of 3-4. The Cardinals have a 10-10-0 ATS record in Liberatore's 20 starts with a set spread. The Cardinals are 7-7 in Liberatore's 14 starts this season that they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (60.2%)

Cubs vs Cardinals Moneyline

• The Cubs vs Cardinals moneyline has Chicago as a -122 favorite, while St. Louis is a +104 underdog at home.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Cubs. The Cardinals are -152 to cover, and the Cubs are +126.

Cubs vs Cardinals Over/Under

• The over/under for the Cubs versus Cardinals game on July 27 has been set at 9.5, with -106 odds on the over and -114 odds on the under.

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Cubs vs Cardinals Betting Trends

• The Cubs have been victorious in 38, or 56.7%, of the 67 contests they have been chosen as favorites in this season.
• Chicago has a record of 29-25 in contests when oddsmakers favor them by -122 or more on the moneyline.
• The Cubs and their opponents have gone over the total this season in 55 of their 101 opportunities.
• The Cubs have posted a record of 46-55-0 against the spread this season.
• The Cardinals have won 34 of the 71 games they were the underdog on the moneyline this season (47.9%).
• When playing as a moneyline underdog with odds of +104 or longer, St. Louis has a 26-25 record (winning 51% of its games).
• The Cardinals have played in 103 games with an over/under set, and have combined with their opponents to go over the total 41 times (41-56-6).
• The Cardinals have collected a 57-46-0 record against the spread this season (covering 55.3% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 114 hits and an OBP of .388, plus a team-best slugging percentage of .545. He's batting .290.
• Among qualifying hitters, he ranks 15th in batting average, his on-base percentage ranks sixth, and he is ninth in slugging.
• Crow-Armstrong will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .474 with three doubles, two triples, two home runs, four walks and seven RBIs.
• Nico Hoerner is hitting .247 with 23 doubles, a triple, four home runs and 36 walks, while slugging .337 with an on-base percentage of .312.
• He is 91st in batting average, 107th in on-base percentage and 143rd in slugging among qualified hitters.
• Hoerner has picked up a hit in three games in a row. In his last five games he is hitting .238 with an RBI.
• Dansby Swanson has collected 76 base hits, an OBP of .299 and a slugging percentage of .413 this season.
• Swanson enters this game with three games in a row with at least one hit. In his last five games he is batting .389 with a double, two walks and three RBIs.
• Michael Busch is batting .247 with a .368 OBP and 56 RBI for Chicago this season.
• Busch has hit safely in two games in a row. In his last five games he is hitting .292 with a double, a walk and three RBIs.

Cardinals Player Leaders

• Jordan Walker has 114 hits, a team-best for the Cardinals. He's batting .286 and slugging .510 with an on-base percentage of .346.
• Including all qualified hitters, he ranks 21st in batting average, while his on-base percentage ranks 55th and he is 16th in slugging.
• Alec Burleson paces his team with a .471 slugging percentage. He has a batting average of .289 with an on-base percentage of .348.
• He ranks 16th in batting average, 51st in on-base percentage and 38th in slugging percentage in the big leagues.
• JJ Wetherholt has 10 doubles, 15 home runs and 45 walks while batting .253.
• Ivan Herrera paces his team with a .366 OBP.

Cubs vs Cardinals Head to Head

• 7/5/2026: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/3/2026: 17-1 STL (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/31/2026: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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