Red Sox vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 5

Odds updated as of 2:11 a.m.

Wednesday's slate in the MLB includes a matchup between the Boston Red Sox and the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Red Sox vs White Sox Game Info

• Boston Red Sox (61-51) vs. Chicago White Sox (59-53)
• Date: Wednesday, August 5, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CHSN

Red Sox vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-118) | CHW: (+100)
• Spread: BOS: +1.5 (-194) | CHW: -1.5 (+160)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Red Sox vs White Sox Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Red Sox) - 13-2, 2.93 ERA vs Sean Burke (White Sox) - 7-5, 3.04 ERA

This contest's pitching matchup is set, as the Red Sox will send Sonny Gray (13-2) to the mound, while Sean Burke (7-5) will take the ball for the White Sox. Gray and his team have a record of 13-6-0 against the spread when he starts. Gray's team has won 68.8% of his starts when they are favored on the moneyline (11-5). The White Sox have a 9-9-0 ATS record in Burke's 18 starts that had a set spread. The White Sox have a 5-8 record in Burke's 13 starts this season when they were the underdog on the moneyline.

Red Sox vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (55.9%)

Red Sox vs White Sox Moneyline

• The moneyline numbers for Red Sox vs. White Sox reveal Boston as the favorite (-118) and Chicago as the underdog (+100) on the road.

Red Sox vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Red Sox. The White Sox are +160 to cover, while the Red Sox are -194 to cover as a 1.5-run underdog on the runline.

Red Sox vs White Sox Over/Under

• An over/under of 8.5 has been set for Red Sox-White Sox on Aug. 5, with the over being -112 and the under -108.

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Red Sox vs White Sox Betting Trends

• The Red Sox have been chosen as favorites in 72 games this year and have walked away with the win 38 times (52.8%) in those games.
• This season Boston has come away with a win 32 times in 60 chances when named as a favorite of at least -118 on the moneyline.
• Contests with the Red Sox have gone over the total set by sportsbooks in 47 of 110 chances this season.
• The Red Sox have posted a record of 55-55-0 against the spread this season.
• The White Sox are 40-43 in games they were the underdog on the moneyline (winning 48.2% of those games).
• Chicago has a 34-36 record (winning 48.6% of its games) when playing as a moneyline underdog of +100 or longer.
• The White Sox have played in 109 games with an over/under set, and have combined with opponents to go over the total 60 times (60-48-1).
• The White Sox have a 64-45-0 record ATS this season (covering 58.7% of the time).

Red Sox Player Leaders

• Willson Contreras has 103 hits and an OBP of .393, both of which rank first among Boston hitters this season. He has a .286 batting average and a slugging percentage of .539.
• Among qualifying batters in the majors, he is 17th in batting average, fifth in on-base percentage, and ninth in slugging.
• Ceddanne Rafaela has hit 15 homers this season while driving in 59 runs. He's batting .289 this season and slugging .478 with an on-base percentage of .330.
• Among qualifying hitters, his batting average places him 13th, his on-base percentage 77th, and his slugging percentage 32nd.
• Rafaela has picked up a hit in nine straight games. In his last 10 games he is batting .357 with three doubles, five home runs and 14 RBIs.
• Wilyer Abreu has 106 hits this season and has a slash line of .251/.324/.452.
• Abreu has recorded a hit in two straight games. In his last five games he is batting .300 with four home runs, three walks and four RBIs.
• Caleb Durbin has been key for Boston with 86 hits, an OBP of .318 plus a slugging percentage of .405.
• Durbin enters this matchup on a two-game hitting streak. In his last five games he is batting .313 with a double, a home run, three walks and five RBIs.

White Sox Player Leaders

• Miguel Vargas paces the White Sox with 97 hits. He's batting .236 and slugging .477 with an on-base percentage of .341.
• Including all the qualifying hitters in MLB, his batting average ranks 115th, his on-base percentage ranks 57th, and he is 33rd in slugging.
• Munetaka Murakami is hitting .244 with 10 doubles, 24 home runs and 58 walks. He's slugging .542 with an on-base percentage of .376.
• Sam Antonacci has accumulated an on-base percentage of .362, a team-high for the White Sox.
• Chase Meidroth's .391 slugging percentage leads his team.

Red Sox vs White Sox Head to Head

• 8/4/2026: 14-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +128)
• 7/9/2026: 2-1 BOS (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/8/2026: 5-0 BOS (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/7/2026: 8-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2025: 4-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 4/20/2025: 8-4 CHW (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 4/19/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 4/18/2025: 10-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/13/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 4/12/2025: 3-2 CHW (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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