Red Sox vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:12 p.m.

Friday's slate in the MLB includes a matchup between the Boston Red Sox and the Detroit Tigers.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Red Sox vs Tigers Game Info

• Boston Red Sox (87-72) vs. Detroit Tigers (86-73)
• Date: Friday, September 26, 2025
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: Apple TV+

Red Sox vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-120) | DET: (+102)
• Spread: BOS: +1.5 (-200) | DET: -1.5 (+164)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Red Sox vs Tigers Probable Starting Pitchers

Probable Pitchers: Kyle Harrison (Red Sox) - 1-1, 3.58 ERA vs Casey Mize (Tigers) - 14-6, 3.91 ERA

This contest's pitching matchup is set, as the Red Sox will send Kyle Harrison (1-1) to the mound, while Casey Mize (14-6) will answer the bell for the Tigers. Harrison and his team have a record of 3-2-0 against the spread when he starts. Harrison's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Tigers have gone 16-10-0 against the spread when Mize starts. The Tigers have a 5-2 record in Mize's seven starts this season when they were the moneyline underdog.

Red Sox vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (52.6%)

Red Sox vs Tigers Moneyline

• The Red Sox vs Tigers moneyline has Boston as a -120 favorite, while Detroit is a +102 underdog on the road.

Red Sox vs Tigers Spread

• The Tigers are 1.5-run favorites against the spread for this matchup with the Red Sox. The Tigers are +164 to cover, while the Red Sox are -200 to cover as a 1.5-run underdog on the runline.

Red Sox vs Tigers Over/Under

• The over/under for the Red Sox versus Tigers game on Sept. 26 has been set at 8.5, with -128 odds on the over and +104 odds on the under.

Bet on Boston Red Sox vs. Detroit Tigers on FanDuel today!

Red Sox vs Tigers Betting Trends

• The Red Sox have been victorious in 57, or 57.6%, of the 99 contests they have been chosen as favorites in this season.
• This year Boston has won 41 of 72 games when listed as at least -120 on the moneyline.
• The Red Sox and their opponents have gone over in 74 of their 158 games with a total set by sportsbooks this season.
• The Red Sox are 84-74-0 against the spread in their 158 games with a line set by sportsbooks this season.
• The Tigers have put together a 21-21 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Detroit is 10-15 (winning 40% of its games) when playing as a moneyline underdog of +102 or longer.
• The Tigers have played in 152 games with a set over/under, and have combined with opponents to go over the total 78 times (78-68-6).
• The Tigers have collected a 71-81-0 record against the spread this season.

Red Sox Player Leaders

• Jarren Duran has 40 doubles, 13 triples, 16 home runs and 60 walks while batting .257. He has an on-base percentage of .334 and a slugging percentage of .444.
• Among the qualified hitters in the majors, his batting average ranks 77th, his on-base percentage ranks 62nd, and he is 62nd in slugging.
• Trevor Story has hit 25 homers this season while driving in 96 runs. He's batting .267 this season and slugging .439 with an on-base percentage of .312.
• His batting average ranks 45th among qualified players, his on-base percentage 106th, and his slugging percentage 66th.
• Story takes a five-game streak with at least one hit into this matchup. In his last five games he is batting .304 with a double, a walk and two RBIs.
• Alex Bregman has 117 hits and an OBP of .360, both of which lead the Red Sox this season.
• Ceddanne Rafaela has 16 home runs, 62 RBI and a batting average of .245 this season.

Tigers Player Leaders

• Gleyber Torres has put up a team-high .362 on-base percentage. He's batting .258 and slugging .392.
• Including all the qualified hitters in MLB, his batting average is 74th, his on-base percentage ranks 19th, and he is 114th in slugging.
• Riley Greene's 155 hits and .500 slugging percentage are both team-highs. He has a batting average of .262 with an on-base percentage of .317.
• Including all qualified players, he ranks 61st in batting average, 98th in on-base percentage and 17th in slugging percentage.
• Spencer Torkelson is batting .240 with 27 doubles, a triple, 31 home runs and 71 walks.
• Zach McKinstry is hitting .261 with 23 doubles, 11 triples, 12 home runs and 46 walks.

Red Sox vs Tigers Head to Head

• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 5/13/2025: 10-9 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/12/2025: 14-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/1/2024: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/31/2024: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/30/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/2/2024: 8-4 DET (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/1/2024: 6-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/31/2024: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/30/2024: 5-0 DET (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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