Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 7:13 a.m.

In MLB action on Tuesday, the Boston Red Sox play the Baltimore Orioles.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Orioles Game Info

• Boston Red Sox (51-48) vs. Baltimore Orioles (49-52)
• Date: Tuesday, July 21, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-136) | BAL: (+116)
• Spread: BOS: -1.5 (+158) | BAL: +1.5 (-192)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Red Sox) - 4-3, 3.15 ERA vs Kyle Bradish (Orioles) - 6-9, 3.61 ERA

The Red Sox will give the nod to Ranger Suarez (4-3, 3.15 ERA), who is eyeing win No. 5 on the season, and the Orioles will counter with Kyle Bradish (6-9, 3.61 ERA). Suarez and his team have a record of 9-8-0 against the spread when he starts. Suarez's team is 6-6 this season when he starts and they are the moneyline favorite. The Orioles have a 9-10-0 record against the spread in Bradish's starts. The Orioles have been the underdog on the moneyline in six of Bradish's starts this season, and they went 4-2 in those matchups.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (50.4%)

Red Sox vs Orioles Moneyline

• Boston is a -136 favorite on the moneyline, while Baltimore is a +116 underdog on the road.

Red Sox vs Orioles Spread

• The Orioles are at +1.5 on the runline against the Red Sox. The Orioles are -192 to cover the spread, and the Red Sox are +158.

Red Sox vs Orioles Over/Under

• Red Sox versus Orioles, on July 21, has an over/under of 8.5, with the over being +100 and the under -122.

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Red Sox vs Orioles Betting Trends

• The Red Sox have been chosen as favorites in 62 games this year and have walked away with the win 31 times (50%) in those games.
• This season Boston has been victorious 11 times in 27 chances when named as a favorite of at least -136 on the moneyline.
• The Red Sox's games have gone over the total in 43 of their 97 opportunities.
• The Red Sox have posted a record of 46-51-0 against the spread this season.
• The Orioles have a 22-25 record in games they were the underdog on the moneyline (winning 46.8% of those games).
• When it has played as a moneyline underdog with odds of +116 or longer, Baltimore has a 6-11 record (winning just 35.3% of its games).
• The Orioles have played in 100 games with a set over/under, and have combined with their opponents to go over the total 54 times (54-43-3).
• The Orioles have a 51-49-0 record ATS this season.

Red Sox Player Leaders

• Willson Contreras leads Boston with 94 hits and an OBP of .384 this season. He has a .289 batting average and a slugging percentage of .557.
• Among all qualifying hitters in the majors, his batting average ranks 16th, his on-base percentage ranks 12th, and he is fifth in slugging.
• Contreras hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .333 with a double, two home runs, two walks and five RBIs.
• Wilyer Abreu is batting .267 with 21 doubles, three triples, 15 home runs and 41 walks. He's slugging .461 with an on-base percentage of .339.
• He is 52nd in batting average, 64th in on-base percentage and 49th in slugging among qualified hitters.
• Ceddanne Rafaela leads Boston in slugging percentage (.433) powered by 36 extra-base hits.
• Rafaela enters this game with eight games in a row with at least one hit. During his last 10 games he is batting .256 with five doubles, a walk and four RBIs.
• Caleb Durbin has 10 home runs, 42 RBI and a batting average of .236 this season.
• Durbin has hit safely in two games in a row. In his last five games he is hitting .350 with a home run and three RBIs.

Orioles Player Leaders

• Pete Alonso has 92 hits, a team-best for the Orioles. He's batting .246 and slugging .460 with an on-base percentage of .347.
• Including all qualified hitters in the majors, he ranks 92nd in batting average, 52nd in on-base percentage and 52nd in slugging percentage.
• Taylor Ward leads his team with a .386 on-base percentage, and has a club-best .361 slugging percentage. He has a batting average of .251.
• He ranks 81st in batting average, ninth in on-base percentage and 123rd in slugging percentage in the big leagues.
• Gunnar Henderson has a .402 slugging percentage, which leads the Orioles.
• Samuel Basallo is hitting .241 with nine doubles, a triple, 16 home runs and 26 walks.

Red Sox vs Orioles Head to Head

• 7/20/2026: 6-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/4/2026: 8-2 BAL (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2026: 8-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/2/2026: 4-2 BAL (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/26/2026: 5-3 BOS (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/25/2026: 17-1 BOS (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/24/2026: 10-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/28/2025: 3-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/27/2025: 3-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/26/2025: 5-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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