Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 1:11 p.m.

The Boston Red Sox are among the MLB squads playing on Wednesday, up against the Baltimore Orioles.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Orioles Game Info

• Boston Red Sox (51-48) vs. Baltimore Orioles (49-52)
• Date: Wednesday, July 22, 2026
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-138) | BAL: (+118)
• Spread: BOS: -1.5 (+140) | BAL: +1.5 (-170)
• Total: 8.5 -- Over: (-122) | Under: (+100)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Jake Bennett (Red Sox) - 5-3, 2.35 ERA vs Dean Kremer (Orioles) - 1-2, 4.15 ERA

The probable pitchers are Jake Bennett (5-3) for the Red Sox and Dean Kremer (1-2) for the Orioles. When Bennett starts, his team is 5-4-0 against the spread this season. When Bennett starts a game and his team is the favorite on the moneyline, they have a record of 2-3. The Orioles are 2-3-0 against the spread when Kremer starts. The Orioles were the underdog on the moneyline for two Kremer starts this season -- they split the games.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (61.2%)

Red Sox vs Orioles Moneyline

• The Red Sox vs Orioles moneyline has Boston as a -138 favorite, while Baltimore is a +118 underdog on the road.

Red Sox vs Orioles Spread

• The Red Sox are 1.5-run home favorites on the runline against the Orioles. The Red Sox are +140 to cover, and the Orioles are -170.

Red Sox vs Orioles Over/Under

• An over/under of 8.5 has been set for Red Sox-Orioles on July 22, with the over being -122 and the under +100.

Bet on Boston Red Sox vs. Baltimore Orioles on FanDuel today!

Red Sox vs Orioles Betting Trends

• The Red Sox have won in 31, or 50%, of the 62 contests they have been named as odds-on favorites in this year.
• This year Boston has won 10 of 23 games when listed as at least -138 on the moneyline.
• The Red Sox's games have gone over the total in 43 of their 97 opportunities.
• In 97 games with a line this season, the Red Sox have a mark of 46-51-0 against the spread.
• The Orioles have won 22 of the 47 games they were the underdog on the moneyline this season (46.8%).
• Baltimore is 6-9 (winning 40% of its games) when playing as a moneyline underdog of +118 or longer.
• The Orioles have had an over/under set by oddsmakers 100 times, and have combined with opponents to go over the total in 54 of those games (54-43-3).
• The Orioles have covered 51% of their games this season, going 51-49-0 ATS.

Red Sox Player Leaders

• Willson Contreras has 94 hits and an OBP of .384, both of which are best among Boston hitters this season. He has a .289 batting average and a slugging percentage of .557.
• Among all qualified batters in MLB, he ranks 16th in batting average, 12th in on-base percentage, and sixth in slugging.
• Contreras has recorded at least one hit in two straight games. In his last five games he is batting .333 with a double, two home runs, two walks and five RBIs.
• Wilyer Abreu has 21 doubles, three triples, 15 home runs and 41 walks. He's batting .267 and slugging .461 with an on-base percentage of .339.
• Among qualifying batters, he ranks 54th in batting average, 64th in on-base percentage and 48th in slugging percentage.
• Ceddanne Rafaela has hit eight homers with a team-high .433 SLG this season.
• Rafaela takes an eight-game hitting streak into this game. During his last 10 games he is hitting .256 with five doubles, a walk and four RBIs.
• Caleb Durbin is batting .236 with a .299 OBP and 42 RBI for Boston this season.
• Durbin has hit safely in two games in a row. During his last five outings he is hitting .350 with a home run and three RBIs.

Orioles Player Leaders

• Pete Alonso has collected 92 hits, a team-high for the Orioles. He's batting .246 and slugging .460 with an on-base percentage of .347.
• Including all qualifying players in the big leagues, he ranks 95th in batting average, 54th in on-base percentage and 49th in slugging percentage.
• Taylor Ward's .386 on-base percentage and .361 slugging percentage are both team-highs. He has a batting average of .251.
• Including all qualified hitters, he is 81st in batting average, 10th in on-base percentage and 125th in slugging percentage.
• Gunnar Henderson has a slugging percentage of .402, a team-best for the Orioles.
• Samuel Basallo is batting .241 with nine doubles, a triple, 16 home runs and 26 walks.

Red Sox vs Orioles Head to Head

• 7/20/2026: 6-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/4/2026: 8-2 BAL (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2026: 8-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/2/2026: 4-2 BAL (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/26/2026: 5-3 BOS (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/25/2026: 17-1 BOS (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/24/2026: 10-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/28/2025: 3-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/27/2025: 3-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/26/2025: 5-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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