Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 6:12 p.m.

The Boston Red Sox are among the MLB squads in action on Tuesday, versus the Cleveland Guardians.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Guardians Game Info

• Boston Red Sox (77-62) vs. Cleveland Guardians (68-68)
• Date: Tuesday, September 2, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CLEG

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-270) | CLE: (+220)
• Spread: BOS: -1.5 (-122) | CLE: +1.5 (+102)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Garrett Crochet (Red Sox) - 14-5, 2.40 ERA vs Slade Cecconi (Guardians) - 5-6, 4.41 ERA

The Red Sox will give the nod to Garrett Crochet (14-5, 2.40 ERA), who is eyeing win No. 15 on the season, and the Guardians will counter with Slade Cecconi (5-6, 4.41 ERA). When Crochet starts, his team is 14-13-0 against the spread this season. Crochet's team has been victorious in 64% of the games he's started as the moneyline favorite with a record of 16-9. The Guardians have an 11-6-0 ATS record in Cecconi's 17 starts with a set spread. The Guardians have been the moneyline underdog in nine of Cecconi's starts this season, and they went 5-4 in those matchups.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (70.3%)

Red Sox vs Guardians Moneyline

• Boston is the favorite, -270 on the moneyline, while Cleveland is a +220 underdog on the road.

Red Sox vs Guardians Spread

• The Guardians are +1.5 on the spread (+102 to cover), and Boston is -122 to cover the runline.

Red Sox vs Guardians Over/Under

• A total of 7.5 runs has been set for the Red Sox-Guardians contest on Sept. 2, with the over available at -115 and the under at -105.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have been chosen as favorites in 86 games this year and have walked away with the win 51 times (59.3%) in those games.
• Boston has a record of 4-1 in contests when bookmakers favor them by -270 or more on the moneyline.
• The Red Sox's games have gone over the total in 66 of their 138 opportunities.
• The Red Sox have an against the spread record of 75-63-0 in 138 games with a line this season.
• The Guardians have a 32-44 record in games they were the underdog on the moneyline (winning 42.1% of those games).
• Cleveland has played as a moneyline underdog of +220 or longer in just two games this season, which it lost both.
• The Guardians have played in 133 games with a set over/under, and have combined with opponents to go over the total 60 times (60-68-5).
• The Guardians have a 69-64-0 record ATS this season.

Red Sox Player Leaders

• Jarren Duran has 138 hits and an OBP of .337 to go with a slugging percentage of .450. All three of those stats are tops among Boston hitters this season. He has a .260 batting average, as well.
• Among all qualifying batters, he is 75th in batting average, his on-base percentage ranks 62nd, and he is 66th in slugging.
• Trevor Story has 23 doubles, 23 home runs and 30 walks. He's batting .260 and slugging .437 with an on-base percentage of .307.
• Among all qualified hitters, he ranks 75th in batting average, 119th in on-base percentage and 75th in slugging percentage.
• Ceddanne Rafaela has 116 hits this season and has a slash line of .248/.293/.420.
• Alex Bregman has 16 home runs, 53 RBI and a batting average of .286 this season.
• Bregman takes a two-game hitting streak into this game. In his last five games he is hitting .095 with a double.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-high OBP (.355), and leads the Guardians in hits (139). He's batting .280 and slugging.
• Including all qualifying hitters, he is 26th in batting average, while his on-base percentage is 31st and he is 23rd in slugging.
• Steven Kwan is slugging .382 to lead his team. He has a batting average of .274 with an on-base percentage of .331.
• Including all qualifying hitters, he ranks 35th in batting average, 76th in on-base percentage and 130th in slugging percentage.
• Kyle Manzardo is hitting .233 with 14 doubles, two triples, 24 home runs and 41 walks.
• Angel Martinez is batting .225 with 21 doubles, a triple, 10 home runs and 16 walks.

Red Sox vs Guardians Head to Head

• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/25/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/24/2024: 8-0 BOS (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/23/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 2-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2024: 10-7 CLE (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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