Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 5:14 a.m.

MLB action on Tuesday includes the Boston Red Sox playing the Cleveland Guardians.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Guardians Game Info

• Boston Red Sox (77-62) vs. Cleveland Guardians (68-68)
• Date: Tuesday, September 2, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CLEG

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-250) | CLE: (+205)
• Spread: BOS: -1.5 (-125) | CLE: +1.5 (+104)
• Total: 8 -- Over: (-114) | Under: (-106)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Garrett Crochet (Red Sox) - 14-5, 2.40 ERA vs Slade Cecconi (Guardians) - 5-6, 4.41 ERA

The probable pitchers are Garrett Crochet (14-5) for the Red Sox and Slade Cecconi (5-6) for the Guardians. When Crochet starts, his team is 14-13-0 against the spread this season. Crochet's team has been victorious in 64% of the games he's started as the moneyline favorite with a record of 16-9. The Guardians have an 11-6-0 record against the spread in Cecconi's starts. The Guardians have a 5-4 record in Cecconi's nine starts this season when they were the moneyline underdog.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (69.9%)

Red Sox vs Guardians Moneyline

• Cleveland is a +205 underdog on the moneyline, while Boston is a -250 favorite at home.

Red Sox vs Guardians Spread

• The Guardians are +1.5 on the run line against the Red Sox. The Guardians are +104 to cover, and the Red Sox are -125.

Red Sox vs Guardians Over/Under

• A combined run total of 8 has been set for Red Sox-Guardians on Sept. 2, with the over at -114 and the under at -106.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have won in 51, or 59.3%, of the 86 contests they have been named as odds-on favorites in this year.
• This season Boston has been victorious five times in seven chances when named as a favorite of at least -250 on the moneyline.
• The Red Sox's games have gone over the total in 66 of their 138 opportunities.
• The Red Sox are 75-63-0 against the spread in their 138 games that had a posted line this season.
• The Guardians have compiled a 32-44 record in games they were listed as the moneyline underdog (winning 42.1% of those games).
• Cleveland has played as a moneyline underdog of +205 or longer in just two games this season, which it lost both.
• The Guardians have had an over/under set by bookmakers 133 times, and have combined with opponents to go over the total in 60 of those games (60-68-5).
• The Guardians have collected a 69-64-0 record ATS this season (covering 51.9% of the time).

Red Sox Player Leaders

• Jarren Duran has 138 hits and an OBP of .337 to go with a slugging percentage of .450. All three of those stats are tops among Boston hitters this season. He has a .260 batting average, as well.
• Among the qualifying batters in MLB, his batting average ranks 75th, his on-base percentage ranks 62nd, and he is 66th in slugging.
• Trevor Story has 23 doubles, 23 home runs and 30 walks. He's batting .260 and slugging .437 with an on-base percentage of .307.
• Among qualified hitters, his batting average ranks him 75th, his on-base percentage 119th, and his slugging percentage 75th.
• Ceddanne Rafaela is batting .248 with a .420 slugging percentage and 56 RBI this year.
• Alex Bregman is batting .286 with a .370 OBP and 53 RBI for Boston this season.
• Bregman heads into this game on a two-game hitting streak. During his last five outings he is hitting .095 with a double.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-high OBP (.355), while pacing the Guardians in hits (139). He's batting .280 and slugging.
• He ranks 26th in batting average, 31st in on-base percentage and 23rd in slugging percentage among all qualifying hitters in the big leagues.
• Steven Kwan is slugging .382 to lead his team. He has a batting average of .274 with an on-base percentage of .331.
• He ranks 35th in batting average, 76th in on-base percentage and 130th in slugging percentage in the big leagues.
• Kyle Manzardo has 14 doubles, two triples, 24 home runs and 41 walks while batting .233.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 16 walks while batting .225.

Red Sox vs Guardians Head to Head

• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/25/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/24/2024: 8-0 BOS (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/23/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 2-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2024: 10-7 CLE (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!