Padres vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 10:11 a.m.

In MLB action on Tuesday, the San Diego Padres take on the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Orioles Game Info

• San Diego Padres (76-62) vs. Baltimore Orioles (62-76)
• Date: Tuesday, September 2, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-172) | BAL: (+144)
• Spread: SD: -1.5 (+125) | BAL: +1.5 (-150)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Padres vs Orioles Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-4, 5.66 ERA vs Tyler Wells (Orioles) - 0-0, 0.00 ERA

The Padres will give the ball to Yu Darvish (3-4, 5.66 ERA), who is eyeing win No. 4 on the season, and the Orioles will counter with Tyler Wells. Darvish's team is 7-2-0 against the spread in his starts this season. Darvish's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. Last season (in three games pitched with a spread) Wells and his team failed to cover the spread each time. Wells' team was the underdog on the moneyline only once in a game he pitched a season ago, and lost.

Padres vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (61.5%)

Padres vs Orioles Moneyline

• Looking at the moneyline for Padres-Orioles, San Diego is the favorite at -172, and Baltimore is +144 playing on the road.

Padres vs Orioles Spread

• The Orioles are at +1.5 on the runline against the Padres. The Orioles are -150 to cover the spread, and the Padres are +125.

Padres vs Orioles Over/Under

• The over/under for the Padres versus Orioles game on Sept. 2 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

Bet on San Diego Padres vs. Baltimore Orioles on FanDuel today!

Padres vs Orioles Betting Trends

• The Padres have won in 43, or 61.4%, of the 70 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win 13 times in 19 chances when named as a favorite of at least -172 on the moneyline.
• The Padres' games have gone over the total in 60 of their 136 opportunities.
• The Padres are 75-61-0 against the spread in their 136 games with a line set by sportsbooks this season.
• The Orioles have won 33 of the 75 games they were listed as the moneyline underdog this season (44%).
• Baltimore has gone 5-8 when playing as a moneyline underdog with odds of +144 or longer (38.5%).
• The Orioles have played in 135 games with a set over/under, and have combined with opponents to go over the total 59 times (59-72-4).
• The Orioles have gone 64-71-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 18 home runs and 81 walks while batting .264. He has an on-base percentage of .370 and a slugging percentage of .430.
• Among qualified hitters in MLB, his batting average ranks 60th, his on-base percentage ranks 14th, and he is 78th in slugging.
• Manny Machado has 151 hits, which is best among San Diego batters this season. He's batting .284 with 53 extra-base hits. He's also slugging .462 with an on-base percentage of .346.
• Among all qualifying players, he ranks 22nd in batting average, 45th in on-base percentage and 50th in slugging percentage.
• Luis Arraez has an OPS of .707, fueled by an OBP of .319 and a team-best slugging percentage of .388 this season.
• Arraez brings a four-game hitting streak into this game. During his last five outings he is batting .353 with a walk and two RBIs.
• Ramon Laureano has been key for San Diego with 108 hits, an OBP of .354 plus a slugging percentage of .541.
• Laureano brings a three-game hitting streak into this game. In his last five games he is hitting .190 with a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has totaled 138 hits with a .349 on-base percentage and a .457 slugging percentage, all club-bests for the Orioles. He's batting .279.
• Including all the qualified hitters in the big leagues, he ranks 27th in batting average, 42nd in on-base percentage and 56th in slugging percentage.
• Henderson hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .300 with a walk and two RBIs.
• Jackson Holliday has 20 doubles, three triples, 15 home runs and 44 walks while batting .245. He's slugging .384 with an on-base percentage of .312.
• Including all qualifying hitters, he ranks 109th in batting average, 112th in on-base percentage and 124th in slugging percentage.
• Ryan Mountcastle is hitting .264 with 17 doubles, five home runs and 12 walks.
• Colton Cowser is batting .210 with 12 doubles, 12 home runs and 17 walks.

Padres vs Orioles Head to Head

• 9/1/2025: 4-3 BAL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 7/28/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/27/2024: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/26/2024: 6-4 SD (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/16/2023: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2023: 10-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/14/2023: 4-1 BAL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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