Rays vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 7:16 p.m.

The Monday slate in MLB includes a matchup between the Tampa Bay Rays and the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Rays vs White Sox Game Info

• Tampa Bay Rays (52-48) vs. Chicago White Sox (35-65)
• Date: Monday, July 21, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CHSN

Rays vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-215) | CHW: (+180)
• Spread: TB: -1.5 (-110) | CHW: +1.5 (-110)
• Total: 9 -- Over: (-102) | Under: (-120)

Rays vs White Sox Probable Starting Pitchers

Probable Pitchers: Shane Baz (Rays) - 8-5, 4.17 ERA vs Sean Burke (White Sox) - 4-8, 4.36 ERA

The Rays will look to Shane Baz (8-5) versus the White Sox and Sean Burke (4-8). Baz and his team have a record of 11-7-0 against the spread when he starts. Baz's team is 6-4 this season when he starts and they are the moneyline favorite. The White Sox have a 10-6-0 record against the spread in Burke's starts. The White Sox have a 7-9 record in Burke's 16 starts this season when they were the moneyline underdog.

Rays vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (69%)

Rays vs White Sox Moneyline

• The Rays vs White Sox moneyline has Tampa Bay as a -215 favorite, while Chicago is a +180 underdog on the road.

Rays vs White Sox Spread

• The White Sox are +1.5 on the run line against the Rays. The White Sox are -110 to cover, and the Rays are -110.

Rays vs White Sox Over/Under

• The over/under for the Rays versus White Sox game on July 21 has been set at 9, with -102 odds on the over and -120 odds on the under.

Bet on Tampa Bay Rays vs. Chicago White Sox on FanDuel today!

Rays vs White Sox Betting Trends

• The Rays have been victorious in 30, or 60%, of the 50 contests they have been chosen as favorites in this season.
• Tampa Bay has played as a favorite of -215 or more just one time this year and came away with a win in that game.
• The Rays and their opponents have gone over in 38 of their 97 games with a total set by sportsbooks this season.
• The Rays are 45-52-0 against the spread in their 97 games that had a posted line this season.
• The White Sox have won 32 of the 94 games they were the moneyline underdog this season (34%).
• When playing as a moneyline underdog with odds of +180 or longer, Chicago has a 5-28 record (winning just 15.2% of its games).
• The White Sox have played in 97 games with an over/under set, and have combined with opponents to go over the total 42 times (42-50-5).
• The White Sox have covered 54.6% of their games this season, going 53-44-0 ATS.

Rays Player Leaders

• Yandy Diaz has an OPS of .820, fueled by an OBP of .352 and a team-best slugging percentage of .468 this season. He has a .294 batting average.
• Among all qualifying batters in baseball, his batting average ranks 11th, his on-base percentage ranks 43rd, and he is 45th in slugging.
• Diaz has picked up at least one hit in five games in a row. During his last five outings he is batting .500 with a double, a home run, four walks and four RBIs.
• Junior Caminero has 96 hits, which leads Tampa Bay batters this season. He's batting .259 with 45 extra-base hits. He's also slugging .515 with an on-base percentage of .296.
• He ranks 76th in batting average, 135th in on-base percentage and 18th in slugging among qualifying hitters.
• Caminero brings a four-game streak with at least one hit into this one. During his last five outings he is batting .333 with a double, two home runs and five RBIs.
• Jonathan Aranda has 102 hits this season and a team-best OBP of .392.
• Brandon Lowe has been key for Tampa Bay with 87 hits, an OBP of .320 plus a slugging percentage of .480.

White Sox Player Leaders

• Miguel Vargas has 25 doubles, two triples, 11 home runs and 36 walks while batting .222. He's slugging .398 with an on-base percentage of .301.
• Including all the qualifying hitters in the big leagues, he ranks 141st in batting average, 128th in on-base percentage and 104th in slugging percentage.
• Andrew Benintendi is hitting .234 with 11 doubles, two triples, 11 home runs and 24 walks. He's slugging .427 with an on-base percentage of .301.
• Luis Robert has nine doubles, 10 home runs and 34 walks while hitting .201.
• Lenyn Sosa paces his team with 81 hits and has a club-leading .417 slugging percentage.

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