Rays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 12:12 p.m.

The Tampa Bay Rays are among the MLB squads playing on Wednesday, versus the Cincinnati Reds.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Rays vs Reds Game Info

• Tampa Bay Rays (12-11) vs. Cincinnati Reds (16-8)
• Date: Wednesday, April 22, 2026
• Time: 1:10 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: Rays.TV and Reds.TV

Rays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-138) | CIN: (+118)
• Spread: TB: -1.5 (+142) | CIN: +1.5 (-172)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Rays vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Martínez (Rays) - 0-1, 2.45 ERA vs Brandon Williamson (Reds) - 2-1, 4.35 ERA

The Rays will look to Nick Martinez (0-1) against the Reds and Brandon Williamson (2-1). Martínez's team is 3-1-0 against the spread this season in his starts. This will be Martinez's first game as the moneyline favorite this season. When Williamson starts, the Reds are 3-1-0 against the spread. The Reds have a 2-1 record in Williamson's three starts this season when they were the underdog on the moneyline.

Rays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (58%)

Rays vs Reds Moneyline

• Tampa Bay is the favorite, -138 on the moneyline, while Cincinnati is a +118 underdog on the road.

Rays vs Reds Spread

• The Rays are favored by 1.5 runs at home versus the Reds. The Rays are +142 to cover the spread, while the Reds are -172.

Rays vs Reds Over/Under

• A total of 8.5 runs has been set for the Rays-Reds contest on April 22, with the over available at -105 and the under at -115.

Bet on Tampa Bay Rays vs. Cincinnati Reds on FanDuel today!

Rays vs Reds Betting Trends

• The Rays have been victorious in six, or 54.5%, of the 11 contests they have been chosen as favorites in this season.
• Tampa Bay has not played a game this season with better moneyline odds than -138.
• Contests with the Rays have gone over the total set by oddsmakers in 16 of 23 chances this season.
• The Rays have an against the spread record of 12-11-0 in 23 games with a line this season.
• The Reds have won 70.6% of the games this season they were the underdog on the moneyline (12-5).
• In games it has played as a moneyline underdog with odds of +118 or longer, Cincinnati has gone 3-2 (60%).
• In the 24 games bookmakers have set an over/under for the Reds, they have combined with opponents to go over the total 13 times (13-10-1).
• The Reds have a 15-9-0 record ATS this season (covering 62.5% of the time).

Rays Player Leaders

• Yandy Diaz leads Tampa Bay in OBP (.413) and total hits (29) this season. He's batting .322 batting average while slugging .478.
• Among qualified hitters in baseball, his batting average ranks ninth, his on-base percentage ranks ninth, and he is 44th in slugging.
• Jonathan Aranda is batting .229 with four doubles, four home runs and 18 walks, while slugging .422 with an on-base percentage of .356.
• Among qualifying hitters, he ranks 115th in batting average, 56th in on-base percentage and 75th in slugging percentage.
• Aranda takes a two-game streak with at least one hit into this one. In his last five games he is batting .250 with a home run, six walks and four RBIs.
• Junior Caminero has collected 24 base hits, an OBP of .349 and a slugging percentage of .457 this season.
• Caminero has recorded at least one base hit in seven straight games. During his last 10 outings he is hitting .310 with two doubles, three home runs, four walks and seven RBIs.
• Chandler Simpson has an OPS of .716, fueled by an OBP of .351 and a team-best slugging percentage of .366 this season.

Reds Player Leaders

• Sal Stewart has an on-base percentage of .394 and has 26 hits, both team-high numbers for the Reds. He's batting .299 and slugging .632.
• Including all qualifying players in the big leagues, he is 20th in batting average, 17th in on-base percentage and third in slugging percentage.
• Elly De La Cruz is slugging .571 to pace his team. He has a batting average of .276 with an on-base percentage of .343.
• Including all qualifying hitters, he is 46th in batting average, 73rd in on-base percentage and 12th in slugging percentage.
• Eugenio Suarez is batting .241 with three doubles, three home runs and nine walks.
• Matt McLain is hitting .198 with five doubles and 15 walks.

Rays vs Reds Head to Head

• 4/21/2026: 12-6 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2026: 6-1 CIN (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/27/2025: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/26/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/25/2025: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/28/2024: 2-1 TB (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/27/2024: 4-0 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/26/2024: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/19/2023: 8-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/18/2023: 10-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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