Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 2:12 a.m.

The MLB's Thursday schedule includes the Pittsburgh Pirates facing the Chicago Cubs.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (12-19) vs. Chicago Cubs (18-13)
• Date: Thursday, May 1, 2025
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-152) | CHC: (+128)
• Spread: PIT: -1.5 (+142) | CHC: +1.5 (-172)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-2, 2.39 ERA vs Colin Rea (Cubs) - 1-0, 0.96 ERA

The Pirates will give the nod to Paul Skenes (3-2) against the Cubs and Colin Rea (1-0). Skenes and his team have a record of 3-3-0 against the spread when he starts. Skenes' team has been victorious in 40% of the games he's started as the moneyline favorite with a record of 2-3. Rea has started two games with set spreads, and the Cubs covered in both opportunities. The Cubs were the moneyline underdog for two Rea starts this season -- they won both.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (56.7%)

Pirates vs Cubs Moneyline

• Pittsburgh is the favorite, -152 on the moneyline, while Chicago is a +128 underdog on the road.

Pirates vs Cubs Spread

• The Pirates are hosting the Cubs and are favored by 1.5 runs (+142 to cover) on the runline. Chicago is -172 to cover.

Pirates vs Cubs Over/Under

• A combined run total of 7.5 has been set for Pirates-Cubs on May 1, with the over at -115 and the under at -105.

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Pirates vs Cubs Betting Trends

• The Pirates have been favorites in 11 games this season and have come away with the win five times (45.5%) in those contests.
• Pittsburgh has been listed as a favorite of -152 or more on two occasions this season and split those games.
• The Pirates' games have gone over the total in 14 of their 31 opportunities.
• The Pirates are 12-19-0 against the spread in their 31 games that had a posted line this season.
• The Cubs have won 50% of the games this season they were the underdog on the moneyline (7-7).
• Chicago has a 2-1 record (winning 66.7% of its games) when playing as a moneyline underdog of +128 or longer.
• The Cubs have combined with opponents to go over the total 19 times this season for a 19-9-1 record against the over/under.
• The Cubs have covered 51.7% of their games this season, going 15-14-0 ATS.

Pirates Player Leaders

• Oneil Cruz has 25 hits and an OBP of .367, both of which are best among Pittsburgh hitters this season. He has a .253 batting average and a slugging percentage of .535.
• Among all qualifying hitters in MLB, he ranks 75th in batting average, 39th in on-base percentage, and 19th in slugging.
• Andrew McCutchen is hitting .277 with six doubles, three home runs and 12 walks, while slugging .458 with an on-base percentage of .368.
• McCutchen takes a three-game streak with at least one hit into this one. During his last five outings he is hitting .368 with two doubles, a home run, two walks and three RBI.
• Isiah Kiner-Falefa has 28 hits this season and has a slash line of .280/.333/.330.
• Ke'Bryan Hayes has one home run, 13 RBI and a batting average of .245 this season.
• Hayes heads into this matchup on a 10-game hitting streak. In his last 10 games he is batting .333 with a double, a walk and five RBI.

Cubs Player Leaders

• Kyle Tucker has put up a team-high .386 on-base percentage. He's batting .279 and slugging .549.
• Including all qualified hitters, he ranks 42nd in batting average, while his on-base percentage is 23rd and he is 12th in slugging.
• Pete Crow-Armstrong has 10 doubles, a triple, six home runs and six walks while hitting .275. He's slugging .525 with an on-base percentage of .315.
• Including all qualified hitters, he is 47th in batting average, 90th in on-base percentage and 23rd in slugging percentage.
• Carson Kelly has a double, a triple, seven home runs and 15 walks while batting .360.
• Ian Happ is slugging .371 to lead his team.

Pirates vs Cubs Head to Head

• 4/30/2025: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/29/2025: 9-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2024: 12-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/3/2024: 5-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/2/2024: 5-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/28/2024: 14-10 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/27/2024: 9-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/26/2024: 18-8 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/19/2024: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/18/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -205, Underdog Moneyline: +172)

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