Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 12:12 p.m.

The Pittsburgh Pirates versus the Chicago Cubs is on the MLB schedule for Thursday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (12-19) vs. Chicago Cubs (18-13)
• Date: Thursday, May 1, 2025
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-130) | CHC: (+110)
• Spread: PIT: -1.5 (+164) | CHC: +1.5 (-200)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-2, 2.39 ERA vs Colin Rea (Cubs) - 1-0, 0.96 ERA

The probable starters are Paul Skenes (3-2) for the Pirates and Colin Rea (1-0) for the Cubs. Skenes' team is 3-3-0 against the spread in his starts this season. Skenes' team has been victorious in 40% of the games he's started as the moneyline favorite with a record of 2-3. Rea has started two games with set spreads, and the Cubs covered in both chances. The Cubs were the moneyline underdog for two Rea starts this season -- they won both.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (56.6%)

Pirates vs Cubs Moneyline

• The moneyline numbers for Pirates vs. Cubs reveal Pittsburgh as the favorite (-130) and Chicago as the underdog (+110) on the road.

Pirates vs Cubs Spread

• The Cubs are at the Pirates, and are +1.5 on the runline. The Cubs are +164 to cover the spread, and the Pirates are -200.

Pirates vs Cubs Over/Under

• The over/under for Pirates-Cubs on May 1 is 7.5. The over is -120, and the under is -102.

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Pirates vs Cubs Betting Trends

• The Pirates have been victorious in five, or 45.5%, of the 11 contests they have been chosen as favorites in this season.
• Pittsburgh has a record of 3-3 when favored by -130 or more this year.
• The Pirates' games have gone over the total in 14 of their 31 opportunities.
• The Pirates have an against the spread record of 12-19-0 in 31 games with a line this season.
• The Cubs have won seven of the 14 games they were the underdog on the moneyline this season (50%).
• When playing as a moneyline underdog with odds of +110 or longer, Chicago has gone 2-5 (28.6%).
• The Cubs have had an over/under set by oddsmakers 29 times, and have combined with opponents to go over the total in 19 of those games (19-9-1).
• The Cubs have a 15-14-0 record against the spread this season.

Pirates Player Leaders

• Oneil Cruz leads Pittsburgh in OBP (.367) and total hits (25) this season. He's batting .253 batting average while slugging .535.
• Among the qualifying batters in MLB, his batting average ranks 75th, his on-base percentage ranks 39th, and he is 19th in slugging.
• Andrew McCutchen is hitting .277 with six doubles, three home runs and 12 walks. He's slugging .458 with an on-base percentage of .368.
• McCutchen has picked up at least one hit in three straight games. In his last five games he is hitting .368 with two doubles, a home run, two walks and three RBI.
• Enmanuel Valdez is batting .227 with a .424 slugging percentage and 11 RBI this year.
• Valdez brings a two-game hitting streak into this game. In his last five games he is batting .250 with a home run, a walk and two RBI.
• Isiah Kiner-Falefa has no home runs, but seven RBI and a batting average of .280 this season.

Cubs Player Leaders

• Kyle Tucker has a team-best .386 on-base percentage. He's batting .279 and slugging .549.
• He ranks 42nd in batting average, 23rd in on-base percentage and 12th in slugging percentage among all qualified hitters in the majors.
• Pete Crow-Armstrong is batting .275 with 10 doubles, a triple, six home runs and six walks. He's slugging .525 with an on-base percentage of .315.
• Including all qualified players, he ranks 47th in batting average, 90th in on-base percentage and 23rd in slugging percentage.
• Carson Kelly has a double, a triple, seven home runs and 15 walks while batting .360.
• Seiya Suzuki's 31 hits lead his team.

Pirates vs Cubs Head to Head

• 4/30/2025: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/29/2025: 9-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2024: 12-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/3/2024: 5-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/2/2024: 5-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/28/2024: 14-10 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/27/2024: 9-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/26/2024: 18-8 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/19/2024: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/18/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -205, Underdog Moneyline: +172)

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