Pirates vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 4:14 a.m.

The Pittsburgh Pirates are among the MLB teams in action on Wednesday, up against the Milwaukee Brewers.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Brewers Game Info

• Pittsburgh Pirates (32-49) vs. Milwaukee Brewers (44-36)
• Date: Wednesday, June 25, 2025
• Time: 2:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: MLB Network, FDSWI, and SportsNet PT

Pirates vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-120) | MIL: (+102)
• Spread: PIT: -1.5 (+152) | MIL: +1.5 (-184)
• Total: 6.5 -- Over: (-115) | Under: (-105)

Pirates vs Brewers Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 4-6, 1.85 ERA vs Jacob Misiorowski (Brewers) - 2-0, 1.64 ERA

The Pirates will give the ball to Paul Skenes (4-6, 1.85 ERA), who is eyeing win No. 5 on the season, and the Brewers will turn to Jacob Misiorowski (2-0, 1.64 ERA). Skenes and his team have a record of 7-9-0 against the spread when he starts. Skenes' team has been victorious in 45.5% of the games he's started as the moneyline favorite with a record of 5-6. Misiorowski has started two games with set spreads, and the Brewers covered in both opportunities. The Brewers were the moneyline underdog for two Misiorowski starts this season -- they won both.

Pirates vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.4%)

Pirates vs Brewers Moneyline

• Looking at the moneyline for Pirates-Brewers, Pittsburgh is the favorite at -120, and Milwaukee is +102 playing at home.

Pirates vs Brewers Spread

• The Brewers are +1.5 on the spread (-184 to cover), and Pittsburgh is +152 to cover the runline.

Pirates vs Brewers Over/Under

• The Pirates-Brewers contest on June 25 has been given an over/under of 6.5 runs. The over is set at -115 and the under at -105.

Bet on Pittsburgh Pirates vs. Milwaukee Brewers on FanDuel today!

Pirates vs Brewers Betting Trends

• The Pirates have been chosen as favorites in 21 games this year and have walked away with the win 10 times (47.6%) in those games.
• This season Pittsburgh has come away with a win six times in 14 chances when named as a favorite of at least -120 on the moneyline.
• The Pirates and their opponents have gone over in 29 of their 75 games with a total set by sportsbooks this season.
• In 75 games with a line this season, the Pirates have a mark of 37-38-0 against the spread.
• The Brewers have a 17-23 record in games they were listed as the moneyline underdog (winning 42.5% of those games).
• Milwaukee has a 12-20 record (winning just 37.5% of its games) when it has played as a moneyline underdog of +102 or longer.
• The Brewers have had an over/under set by oddsmakers 79 times, and have combined with opponents to go over the total in 33 of those games (33-45-1).
• The Brewers have gone 41-38-0 ATS this season.

Pirates Player Leaders

• Oneil Cruz is hitting .208 with 10 doubles, a triple, 13 home runs and 42 walks. He has an on-base percentage of .321 while slugging .404.
• Among qualifying hitters in baseball, his batting average ranks 154th, his on-base percentage ranks 98th, and he is 102nd in slugging.
• Andrew McCutchen has 65 hits and an OBP of .338, both of which lead the Pirates this season. He's batting .259 and slugging .406.
• His batting average ranks 77th among qualified players, his on-base percentage 67th, and his slugging percentage 101st.
• Bryan Reynolds has an OPS of .677, fueled by an OBP of .304 and a team-best slugging percentage of .373 this season.
• Reynolds enters this matchup with three games in a row with at least one hit. During his last five outings he is batting .389 with three doubles and a walk.
• Isiah Kiner-Falefa has one home run, 18 RBI and a batting average of .276 this season.
• Kiner-Falefa has hit safely in two straight games. In his last five games he is batting .125 with a triple, a walk and an RBI.

Brewers Player Leaders

• Jackson Chourio has a .445 slugging percentage, which paces the Brewers. He's batting .257 with an on-base percentage of .287.
• Including all qualifying hitters, he is 79th in batting average, while his on-base percentage is 143rd and he is 60th in slugging.
• Christian Yelich paces his team with 75 hits. He has a batting average of .264 while slugging .458 with an on-base percentage of .344.
• Including all qualified hitters, his batting average places him 66th, his on-base percentage is 58th, and he is 55th in slugging.
• Sal Frelick is batting .295 with nine doubles, three triples, four home runs and 21 walks.
• Brice Turang is hitting .277 with 11 doubles, five home runs and 35 walks.

Pirates vs Brewers Head to Head

• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2024: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/25/2024: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/24/2024: 7-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/11/2024: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!