Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 6:12 a.m.

The Wednesday schedule in MLB includes a matchup between the Chicago Cubs and the St. Louis Cardinals.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (46-33) vs. St. Louis Cardinals (44-36)
• Date: Wednesday, June 25, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-136) | STL: (+116)
• Spread: CHC: -1.5 (+126) | STL: +1.5 (-152)
• Total: 9 -- Over: (-100) | Under: (-122)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 6-3, 2.84 ERA vs Erick Fedde (Cardinals) - 3-6, 3.54 ERA

The Cubs will give the ball to Matthew Boyd (6-3, 2.84 ERA), who is eyeing win No. 7 on the season, and the Cardinals will counter with Erick Fedde (3-6, 3.54 ERA). Boyd and his team are 5-10-0 ATS this season when he starts. Boyd's team has a record of 7-3 this season when he starts and they are the favorite on the moneyline. When Fedde starts, the Cardinals are 8-7-0 against the spread. The Cardinals have a 3-7 record in Fedde's 10 starts this season when they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.6%)

Cubs vs Cardinals Moneyline

• St. Louis is a +116 underdog on the moneyline, while Chicago is a -136 favorite on the road.

Cubs vs Cardinals Spread

• The Cubs are 1.5-run road favorites on the runline against the Cardinals. The Cubs are +126 to cover, and the Cardinals are -152.

Cubs vs Cardinals Over/Under

• A total of 9 runs has been set for the Cubs-Cardinals game on June 25, with the over available at -100 and the under at -122.

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Cubs vs Cardinals Betting Trends

• The Cubs have been victorious in 35, or 68.6%, of the 51 contests they have been chosen as favorites in this season.
• Chicago has a record of 25-10 in contests when oddsmakers favor them by -136 or more on the moneyline.
• The Cubs and their opponents have gone over in 42 of their 77 games with a total set by sportsbooks this season.
• The Cubs have an against the spread record of 38-39-0 in 77 games with a line this season.
• The Cardinals have won 24 of the 44 games they were the underdog on the moneyline this season (54.5%).
• When playing as a moneyline underdog with odds of +116 or longer, St. Louis has gone 9-10 (47.4%).
• The Cardinals have had an over/under set by oddsmakers 80 times, and have combined with opponents to go over the total in 43 of those games (43-34-3).
• The Cardinals have a 44-36-0 record ATS this season (covering 55% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .397 this season while batting .288 with 52 walks and 56 runs scored. He has a slugging percentage of .524.
• Among the qualifying hitters in MLB, his batting average ranks 27th, his on-base percentage ranks fifth, and he is 14th in slugging.
• Pete Crow-Armstrong leads Chicago with 83 hits. He is batting .273 this season and has 43 extra-base hits. He's also slugging .563 with an on-base percentage of .310.
• Among qualifying batters, his batting average places him 52nd, his on-base percentage 117th, and his slugging percentage sixth.
• Crow-Armstrong brings a four-game streak with at least one hit into this contest. During his last five outings he is batting .316 with three doubles, a home run and an RBI.
• Seiya Suzuki has collected 79 base hits, an OBP of .315 and a slugging percentage of .546 this season.
• Suzuki brings a three-game hitting streak into this matchup. During his last five outings he is hitting .333 with a double, three home runs, a walk and six RBIs.
• Nico Hoerner has an OPS of .706, fueled by an OBP of .335 and a team-best slugging percentage of .370 this season.
• Hoerner has hit safely in three straight games. During his last five outings he is hitting .389 with a home run and three RBIs.

Cardinals Player Leaders

• Brendan Donovan has a .377 on-base percentage and a .438 slugging percentage, both team-best numbers for the Cardinals. He's batting .310.
• Including all qualifying hitters, he is ninth in batting average, while his on-base percentage is 19th and he is 68th in slugging.
• Nolan Arenado is batting .247 with 11 doubles, a triple, 10 home runs and 23 walks. He's slugging .399 with an on-base percentage of .309.
• Including all qualified players, he ranks 102nd in batting average, 120th in on-base percentage and 109th in slugging percentage.
• Lars Nootbaar is batting .230 with 13 doubles, 11 home runs and 44 walks.
• Willson Contreras has 18 doubles, 10 home runs and 25 walks while hitting .248.

Cubs vs Cardinals Head to Head

• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/14/2024: 8-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/13/2024: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/13/2024: 11-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2024: 5-1 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -196, Underdog Moneyline: +164)

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