Phillies vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 6:12 a.m.

The MLB slate on Wednesday includes the Philadelphia Phillies taking on the Houston Astros.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs Astros Game Info

• Philadelphia Phillies (47-32) vs. Houston Astros (46-33)
• Date: Wednesday, June 25, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-PH

Phillies vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-158) | HOU: (+134)
• Spread: PHI: -1.5 (+105) | HOU: +1.5 (-126)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Phillies vs Astros Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 7-2, 2.61 ERA vs Colton Gordon (Astros) - 2-1, 4.54 ERA

The Phillies will call on Zack Wheeler (7-2) against the Astros and Colton Gordon (2-1). Wheeler's team is 8-7-0 against the spread this season in his starts. When Wheeler starts a game and his team is the favorite on the moneyline, they have a record of 11-2. The Astros have a 4-3-0 record against the spread in Gordon's starts. The Astros have played as the moneyline underdog for three of Gordon's starts this season, and they won each time.

Phillies vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (52.2%)

Phillies vs Astros Moneyline

• The Phillies vs Astros moneyline has Philadelphia as a -158 favorite, while Houston is a +134 underdog at home.

Phillies vs Astros Spread

• The Phillies are at the Astros and are favored by 1.5 runs (+105 to cover) on the runline. Houston is -126 to cover.

Phillies vs Astros Over/Under

• Phillies versus Astros on June 25 has an over/under of 7.5 runs, with the odds on the over -106 and the under set at -114.

Bet on Philadelphia Phillies vs. Houston Astros on FanDuel today!

Phillies vs Astros Betting Trends

• The Phillies have been chosen as favorites in 61 games this year and have walked away with the win 41 times (67.2%) in those games.
• Philadelphia has a record of 25-7 in contests when oddsmakers favor them by -158 or more on the moneyline.
• Contests with the Phillies have gone over the total set by sportsbooks in 31 of 75 chances this season.
• In 75 games with a line this season, the Phillies have a mark of 38-37-0 against the spread.
• The Astros have won 13 of the 23 games they were the moneyline underdog this season (56.5%).
• Houston has played as a moneyline underdog of +134 or longer in only two games this season, which it won both.
• The Astros have played in 78 games with an over/under set, and have combined with opponents to go over the total 31 times (31-45-2).
• The Astros have collected a 40-38-0 record against the spread this season (covering 51.3% of the time).

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.378) and total hits (71) this season. He's batting .247 batting average while slugging .535.
• Among qualified hitters in MLB, his batting average ranks 102nd, his on-base percentage ranks 18th, and he is 13th in slugging.
• Trea Turner has hit nine homers this season while driving in 35 runs. He's batting .300 this season and slugging .448 with an on-base percentage of .355.
• He ranks 18th in batting average, 39th in on-base percentage and 57th in slugging in the majors.
• Turner has picked up at least one hit in two games in a row. In his last five games he is hitting .238 with a double and an RBI.
• Nick Castellanos is batting .285 with a .443 slugging percentage and 41 RBI this year.
• Castellanos enters this game with four games in a row with at least one hit. In his last five games he is batting .350 with three doubles, a home run, a walk and five RBIs.
• Alec Bohm has seven home runs, 36 RBI and a batting average of .287 this season.

Astros Player Leaders

• Jeremy Pena has totaled 100 hits with a .382 on-base percentage and a .495 slugging percentage, all club-bests for the Astros. He's batting .326.
• Including all qualifying hitters in the big leagues, he is fifth in batting average, 16th in on-base percentage and 25th in slugging percentage.
• Isaac Paredes has 10 doubles, a triple, 16 home runs and 42 walks while batting .254. He's slugging .471 with an on-base percentage of .360.
• His batting average ranks 90th among all qualified players, his on-base percentage ranks 33rd, and he is 40th in slugging.
• Jose Altuve is hitting .266 with 10 doubles, 12 home runs and 25 walks.
• Jake Meyers is hitting .307 with 13 doubles, a triple, three home runs and 23 walks.

Phillies vs Astros Head to Head

• 6/24/2025: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/28/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2024: 5-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/30/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2023: 6-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/28/2023: 3-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 11/5/2022: 4-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 11/3/2022: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 11/2/2022: 5-0 HOU (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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