Phillies vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 2:11 a.m.

The Philadelphia Phillies versus the Chicago White Sox is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Phillies vs White Sox Game Info

• Philadelphia Phillies (33-29) vs. Chicago White Sox (33-29)
• Date: Friday, June 5, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and CHSN

Phillies vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-188) | CHW: (+158)
• Spread: PHI: -1.5 (+108) | CHW: +1.5 (-130)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Phillies vs White Sox Probable Starting Pitchers

Probable Pitchers: Jesús Luzardo (Phillies) - 4-4, 4.30 ERA vs Anthony Kay (White Sox) - 5-1, 3.77 ERA

This contest's pitching matchup is set, as the Phillies will send Jesus Luzardo (4-4) to the mound, while Anthony Kay (5-1) will answer the bell for the White Sox. Luzardo's team is 5-7-0 against the spread in his starts this season. Luzardo's team has a record of 4-5 this season when he starts and they are the favorite on the moneyline. The White Sox are 7-2-0 ATS in Kay's nine starts with a set spread. The White Sox have been the underdog on the moneyline in nine of Kay's starts this season, and they went 6-3 in those games.

Phillies vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.5%)

Phillies vs White Sox Moneyline

• Looking at the moneyline for White Sox-Phillies, Chicago is the underdog at +158, and Philadelphia is -188 playing at home.

Phillies vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Phillies. The White Sox are -130 to cover the spread, and the Phillies are +108.

Phillies vs White Sox Over/Under

• A total of 8.5 runs has been set for the Phillies-White Sox contest on June 5, with the over available at -105 and the under at -115.

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Phillies vs White Sox Betting Trends

• The Phillies have come away with 25 wins in the 42 contests they have been listed as the favorites in this season.
• This season Philadelphia has been victorious eight times in nine chances when named as a favorite of at least -188 on the moneyline.
• The Phillies' games have gone over the total in 26 of their 61 opportunities.
• The Phillies are 19-42-0 against the spread in their 61 games with a line set by sportsbooks this season.
• The White Sox have won 49% of the games this season they were the underdog on the moneyline (24-25).
• When playing as a moneyline underdog with odds of +158 or longer, Chicago has a 1-2 record (winning just 33.3% of its games).
• The White Sox have played in 60 games with a set over/under, and have combined with opponents to go over the total 34 times (34-25-1).
• The White Sox have a 35-25-0 record against the spread this season (covering 58.3% of the time).

Phillies Player Leaders

• Bryce Harper has 56 hits this season and a team-best OBP of .363. He has a .259 batting average and a slugging percentage of .509.
• Among qualifying hitters, he is 64th in batting average, his on-base percentage ranks 36th, and he is 23rd in slugging.
• Kyle Schwarber has 52 hits, which is best among Philadelphia batters this season. He's batting .233 with 33 extra-base hits. He's also slugging .592 with an on-base percentage of .352.
• Among qualifying hitters, he is 119th in batting average, 51st in on-base percentage and third in slugging percentage.
• Schwarber takes a two-game streak with at least one hit into this matchup. In his last five games he is hitting .176 with a home run, five walks and an RBI.
• Brandon Marsh is slashing .333/.363/.478 this season and leads the Phillies with an OPS of .840.
• Marsh takes a three-game hitting streak into this game. In his last five games he is hitting .412 with a walk and an RBI.
• Trea Turner is batting .228 with a .276 OBP and 20 RBI for Philadelphia this season.
• Turner heads into this matchup on a five-game hitting streak. In his last five games he is batting .300 with an RBI.

White Sox Player Leaders

• Miguel Vargas is batting .242 with 10 doubles, a triple, 15 home runs and 40 walks. He's slugging .502 with an on-base percentage of .368.
• Including all qualifying players, he is 102nd in batting average, while his on-base percentage ranks 31st and he is 26th in slugging.
• Vargas takes a three-game hitting streak into this game. During his last five outings he is hitting .316 with a double, two home runs, three walks and seven RBIs.
• Chase Meidroth leads his team with a .397 slugging percentage. He has a batting average of .272 with an on-base percentage of .345.
• Including all qualified hitters, his batting average places him 49th, his on-base percentage is 64th, and he is 101st in slugging.
• Colson Montgomery is batting .222 with 11 doubles, 15 home runs and 22 walks.
• Sam Antonacci is hitting .291 with eight doubles, two triples, a home run and 11 walks.

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