Phillies vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 6:13 p.m.

The Friday schedule in MLB includes a matchup between the Philadelphia Phillies and the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs White Sox Game Info

• Philadelphia Phillies (33-29) vs. Chicago White Sox (33-29)
• Date: Friday, June 5, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and CHSN

Phillies vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-190) | CHW: (+160)
• Spread: PHI: -1.5 (+105) | CHW: +1.5 (-126)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Phillies vs White Sox Probable Starting Pitchers

Probable Pitchers: Jesús Luzardo (Phillies) - 4-4, 4.30 ERA vs Anthony Kay (White Sox) - 5-1, 3.77 ERA

The Phillies will give the nod to Jesus Luzardo (4-4, 4.30 ERA), who is eyeing win No. 5 on the season, and the White Sox will counter with Anthony Kay (5-1, 3.77 ERA). When Luzardo starts, his team is 5-7-0 against the spread this season. Luzardo's team is 4-5 this season when he starts and they are the moneyline favorite. The White Sox have a 7-2-0 ATS record in Kay's nine starts that had a set spread. The White Sox have been the moneyline underdog in nine of Kay's starts this season, and they went 6-3 in those games.

Phillies vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.5%)

Phillies vs White Sox Moneyline

• Philadelphia is the favorite, -190 on the moneyline, while Chicago is a +160 underdog on the road.

Phillies vs White Sox Spread

• The White Sox are +1.5 on the spread (-126 to cover), and Philadelphia is +105 to cover the runline.

Phillies vs White Sox Over/Under

• The Phillies-White Sox game on June 5 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

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Phillies vs White Sox Betting Trends

• The Phillies have been favorites in 42 games this season and have come away with the win 25 times (59.5%) in those contests.
• Philadelphia has a record of 7-1 when favored by -190 or more this year.
• The Phillies and their opponents have gone over the total this season in 26 of their 61 opportunities.
• The Phillies have an against the spread mark of 19-42-0 in 61 games with a line this season.
• The White Sox have won 24 of the 49 games they were listed as the moneyline underdog this season (49%).
• Chicago has played as a moneyline underdog of +160 or longer in just two games this season, which it split 1-1.
• The White Sox have played in 60 games with an over/under set, and have combined with their opponents to go over the total 34 times (34-25-1).
• The White Sox have gone 35-25-0 against the spread this season.

Phillies Player Leaders

• Bryce Harper leads Philadelphia in OBP (.363) this season, fueled by 56 hits. He has a .259 batting average and a slugging percentage of .509.
• Among all qualified hitters in baseball, his batting average ranks 64th, his on-base percentage ranks 37th, and he is 23rd in slugging.
• Kyle Schwarber has 52 hits, which leads Philadelphia batters this season. He's batting .233 with 33 extra-base hits. He's also slugging .592 with an on-base percentage of .352.
• Among qualified hitters, his batting average places him 119th, his on-base percentage 51st, and his slugging percentage third.
• Schwarber brings a two-game streak with at least one hit into this matchup. In his last five games he is batting .176 with a home run, five walks and an RBI.
• Brandon Marsh is slashing .333/.363/.478 this season and leads the Phillies with an OPS of .840.
• Marsh takes a three-game hitting streak into this game. During his last five outings he is batting .412 with a walk and an RBI.
• Trea Turner is batting .228 with a .276 OBP and 20 RBI for Philadelphia this season.
• Turner takes a five-game hitting streak into this game. In his last five games he is hitting .300 with an RBI.

White Sox Player Leaders

• Miguel Vargas has 10 doubles, a triple, 15 home runs and 40 walks while hitting .242. He's slugging .502 with an on-base percentage of .368.
• Including all qualified hitters in MLB, his batting average puts him 102nd, his on-base percentage ranks 31st, and he is 26th in slugging.
• Vargas takes a three-game hitting streak into this matchup. During his last five outings he is hitting .316 with a double, two home runs, three walks and seven RBIs.
• Chase Meidroth's .397 slugging percentage leads his team. He has a batting average of .272 with an on-base percentage of .345.
• Including all qualified hitters, he is 49th in batting average, 64th in on-base percentage and 101st in slugging percentage.
• Colson Montgomery is batting .222 with 11 doubles, 15 home runs and 22 walks.
• Sam Antonacci is batting .291 with eight doubles, two triples, a home run and 11 walks.

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