Phillies vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

On Tuesday in MLB, the Philadelphia Phillies are up against the Boston Red Sox.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs Red Sox Game Info

• Philadelphia Phillies (57-43) vs. Boston Red Sox (54-48)
• Date: Tuesday, July 22, 2025
• Time: 6:45 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: TBS, NBCS-PH, and NESN

Phillies vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-188) | BOS: (+158)
• Spread: PHI: -1.5 (+108) | BOS: +1.5 (-130)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Phillies vs Red Sox Probable Starting Pitchers

Probable Pitchers: Cristopher Sanchez (Phillies) - 8-2, 2.43 ERA vs Richard Fitts (Red Sox) - 1-3, 4.28 ERA

The Phillies will look to Cristopher Sanchez (8-2) versus the Red Sox and Richard Fitts (1-3). When Sanchez starts, his team is 11-8-0 against the spread this season. Sanchez's team has won 81.2% of his starts when they are favored on the moneyline (13-3). The Red Sox have gone 2-5-0 ATS in Fitts' seven starts with a set spread. The Red Sox were the moneyline underdog for three Fitts starts this season -- they lost each time.

Phillies vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.8%)

Phillies vs Red Sox Moneyline

• Looking at the moneyline for Phillies-Red Sox, Philadelphia is the favorite at -188, and Boston is +158 playing on the road.

Phillies vs Red Sox Spread

• The Red Sox are +1.5 on the run line against the Phillies. The Red Sox are -130 to cover, and the Phillies are +108.

Phillies vs Red Sox Over/Under

• An over/under of 8.5 has been set for Phillies-Red Sox on July 22, with the over being -105 and the under -115.

Bet on Philadelphia Phillies vs. Boston Red Sox on FanDuel today!

Phillies vs Red Sox Betting Trends

• The Phillies have been chosen as favorites in 75 games this year and have walked away with the win 49 times (65.3%) in those games.
• Philadelphia has a record of 18-3 when favored by -188 or more this year.
• The Phillies and their opponents have gone over in 37 of their 94 games with a total set by sportsbooks this season.
• The Phillies are 47-47-0 against the spread in their 94 games that had a posted line this season.
• The Red Sox have been the moneyline underdog 33 total times this season. They've gone 14-19 in those games.
• Boston has a 1-3 record (winning just 25% of its games) when it has played as a moneyline underdog of +158 or longer.
• The Red Sox have combined with opponents to hit the over on the total 47 times this season for a 47-50-4 record against the over/under.
• The Red Sox have a 55-46-0 record against the spread this season (covering 54.5% of the time).

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia with 91 hits, batting .248 this season with 47 extra-base hits. He has an on-base percentage of .377 and a slugging percentage of .553.
• Among qualified batters, he is 105th in batting average, his on-base percentage ranks 14th, and he is 10th in slugging.
• Trea Turner has hit 11 homers this season while driving in 41 runs. He's batting .286 this season and slugging .425 with an on-base percentage of .343.
• Among qualifying batters, he is 22nd in batting average, 59th in on-base percentage and 80th in slugging percentage.
• Bryce Harper has 73 hits this season and a team-best OBP of .379.
• Nick Castellanos has 12 home runs, 53 RBI and a batting average of .270 this season.

Red Sox Player Leaders

• Ceddanne Rafaela has 90 hits, a team-best for the Red Sox. He's batting .270 and slugging .471 with an on-base percentage of .311.
• Including all qualified hitters in MLB, he is 55th in batting average, 119th in on-base percentage and 41st in slugging percentage.
• Jarren Duran's .323 OBP and .433 slugging percentage both pace his team. He has a batting average of .257.
• His batting average ranks 84th among all qualified players, his on-base percentage is 92nd, and he is 73rd in slugging.
• Wilyer Abreu is batting .253 with 11 doubles, 20 home runs and 31 walks.
• Trevor Story is batting .252 with 13 doubles, 15 home runs and 19 walks.

Phillies vs Red Sox Head to Head

• 7/21/2025: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/13/2024: 9-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/12/2024: 8-6 BOS (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/11/2024: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/7/2023: 6-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 10, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/6/2023: 7-4 BOS (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/5/2023: 5-3 BOS (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)

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