Phillies vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:11 p.m.

Monday's slate in the MLB includes a matchup between the Philadelphia Phillies and the Boston Red Sox.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Red Sox Game Info

• Philadelphia Phillies (56-43) vs. Boston Red Sox (54-47)
• Date: Monday, July 21, 2025
• Time: 6:45 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and NESN

Phillies vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-225) | BOS: (+188)
• Spread: PHI: -1.5 (-113) | BOS: +1.5 (-106)
• Total: 8 -- Over: (-105) | Under: (-115)

Phillies vs Red Sox Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 9-3, 2.36 ERA vs Walker Buehler (Red Sox) - 6-6, 6.12 ERA

The Phillies will give the nod to Zack Wheeler (9-3, 2.36 ERA), who is eyeing win No. 10 on the season, and the Red Sox will turn to Walker Buehler (6-6, 6.12 ERA). When Wheeler starts, his team is 10-9-0 against the spread this season. Wheeler's team has a record of 13-4 this season when he starts and they are the favorite on the moneyline. The Red Sox are 8-8-0 ATS in Buehler's 16 starts that had a set spread. The Red Sox are 2-4 in Buehler's six starts this season that they were the underdog on the moneyline.

Phillies vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.6%)

Phillies vs Red Sox Moneyline

• Looking at the moneyline for Red Sox-Phillies, Boston is the underdog at +188, and Philadelphia is -225 playing at home.

Phillies vs Red Sox Spread

• The Phillies are 1.5-run home favorites on the runline against the Red Sox. The Phillies are -113 to cover, and the Red Sox are -106.

Phillies vs Red Sox Over/Under

• Phillies versus Red Sox on July 21 has an over/under of 8 runs, with the odds on the over -105 and the under set at -115.

Bet on Philadelphia Phillies vs. Boston Red Sox on FanDuel today!

Phillies vs Red Sox Betting Trends

• The Phillies have been chosen as favorites in 74 games this year and have walked away with the win 48 times (64.9%) in those games.
• This year Philadelphia has won eight of nine games when listed as at least -225 on the moneyline.
• The Phillies and their opponents have gone over in 37 of their 93 games with a total set by sportsbooks this season.
• The Phillies are 47-46-0 against the spread in their 93 games that had a posted line this season.
• The Red Sox have been the moneyline underdog 32 total times this season. They've finished 14-18 in those games.
• Boston has played as a moneyline underdog of +188 or longer in only two games this season, which it split 1-1.
• The Red Sox have played in 100 games with a set over/under, and have combined with their opponents to go over the total 47 times (47-49-4).
• The Red Sox are 54-46-0 ATS this season.

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.380) and total hits (91) this season. He's batting .251 batting average while slugging .559.
• Among qualified hitters, he ranks 94th in batting average, his on-base percentage ranks ninth, and he is seventh in slugging.
• Schwarber has hit safely in three straight games. During his last five outings he is hitting .200 with a double, two home runs, three walks and five RBIs.
• Trea Turner leads Philadelphia in slugging percentage (.429) thanks to 32 extra-base hits. He's batting .288 with an on-base percentage of .344.
• His batting average is 20th among qualified players, his on-base percentage 56th, and his slugging percentage 74th.
• Turner has picked up at least one hit in three games in a row. During his last five outings he is hitting .211 with a double, three walks and an RBI.
• Bryce Harper is batting .268 with a .491 slugging percentage and 41 RBI this year.
• Nick Castellanos has 12 home runs, 52 RBI and a batting average of .270 this season.

Red Sox Player Leaders

• Ceddanne Rafaela is leading the Red Sox with 88 hits. He's batting .267 and slugging .471 with an on-base percentage of .309.
• Including all the qualifying hitters in MLB, his batting average is 63rd, his on-base percentage ranks 117th, and he is 40th in slugging.
• Jarren Duran's .322 OBP and .427 slugging percentage both lead his team. He has a batting average of .257.
• Including all qualified players, he ranks 84th in batting average, 92nd in on-base percentage and 76th in slugging percentage.
• Wilyer Abreu is hitting .256 with 11 doubles, 20 home runs and 31 walks.
• Trevor Story has 13 doubles, 15 home runs and 19 walks while batting .249.

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