Padres vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:11 a.m.

The San Diego Padres will take on the Kansas City Royals in MLB action on Saturday.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Royals Game Info

• San Diego Padres (40-35) vs. Kansas City Royals (38-38)
• Date: Saturday, June 21, 2025
• Time: 7:15 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: FOX

Padres vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-166) | KC: (+140)
• Spread: SD: -1.5 (+128) | KC: +1.5 (-154)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Padres vs Royals Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 2-6, 4.69 ERA vs Noah Cameron (Royals) - 2-2, 1.91 ERA

The Padres will give the nod to Dylan Cease (2-6) versus the Royals and Noah Cameron (2-2). When Cease starts, his team is 7-8-0 against the spread this season. Cease's team has won 66.7% of his starts when they are favored on the moneyline (6-3). The Royals have a 4-3-0 ATS record in Cameron's seven starts with a set spread. The Royals have a 2-3 record in Cameron's five starts this season when they were the underdog on the moneyline.

Padres vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.6%)

Padres vs Royals Moneyline

• The moneyline numbers for Padres vs. Royals reveal San Diego as the favorite (-166) and Kansas City as the underdog (+140) on the road.

Padres vs Royals Spread

• The Padres are 1.5-run home favorites on the runline against the Royals. The Padres are +128 to cover, and the Royals are -154.

Padres vs Royals Over/Under

• Padres versus Royals on June 21 has an over/under of 7.5 runs, with the odds on the over -122 and the under set at -100.

Bet on San Diego Padres vs. Kansas City Royals on FanDuel today!

Padres vs Royals Betting Trends

• The Padres have been victorious in 21, or 60%, of the 35 contests they have been chosen as favorites in this season.
• San Diego has a record of 9-6 when favored by -166 or more this year.
• The Padres and their opponents have gone over the total this season in 32 of their 74 opportunities.
• The Padres are 40-34-0 against the spread in their 74 games with a line set by sportsbooks this season.
• The Royals have gone 23-22 in games they were the underdog on the moneyline (winning 51.1% of those games).
• Kansas City has gone 3-3 when playing as a moneyline underdog with odds of +140 or longer (50%).
• The Royals have combined with opponents to go over the total 30 times this season for a 30-44-2 record against the over/under.
• The Royals are 41-35-0 ATS this season.

Padres Player Leaders

• Manny Machado leads San Diego in OBP (.371), slugging percentage (.507) and total hits (89) this season. He has a .311 batting average.
• Among qualifying hitters in MLB, he ranks 11th in batting average, 25th in on-base percentage, and 19th in slugging.
• Machado will look for his third straight game with a hit in this contest. In his last five games he is hitting .250 with a double, two home runs, two walks and three RBIs.
• Fernando Tatis Jr. is batting .267 with 11 doubles, a triple, 13 home runs and 35 walks. He's slugging .452 with an on-base percentage of .355.
• He ranks 56th in batting average, 42nd in on-base percentage and 54th in slugging in the major leagues.
• Luis Arraez has 79 hits this season and has a slash line of .280/.311/.397.
• Arraez has recorded a hit in seven straight games. During his last 10 games he is hitting .311 with three doubles, a triple, a walk and four RBIs.
• Gavin Sheets has 12 home runs, 45 RBI and a batting average of .266 this season.
• Sheets has safely hit in 11 straight games. In his last 10 outings he is batting .361 with three doubles, a home run, five walks and seven RBIs.

Royals Player Leaders

• Bobby Witt Jr. has 25 doubles, three triples, 10 home runs and 26 walks while hitting .284. He's slugging .490 with an on-base percentage of .342.
• Including all the qualified players in the big leagues, his batting average ranks 31st, his on-base percentage is 59th, and he is 24th in slugging.
• Witt brings a five-game hitting streak into this game. In his last five games he is hitting .400 with three doubles, two home runs, two walks and three RBIs.
• Maikel Garcia leads his team with 87 hits and a .375 on-base percentage, with a team-best .498 slugging percentage. He has a batting average of .319.
• Including all qualified hitters, he is seventh in batting average, 22nd in on-base percentage and 22nd in slugging percentage.
• Vinnie Pasquantino is batting .271 with seven doubles, a triple, 11 home runs and 23 walks.
• Jonathan India has 13 doubles, four home runs and 28 walks while hitting .245.

Padres vs Royals Head to Head

• 6/20/2025: 6-5 KC (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/2/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/1/2024: 7-3 SD (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/31/2024: 11-8 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2023: 4-3 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 5/16/2023: 5-4 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/15/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/28/2022: 15-7 KC (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/27/2022: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 8/26/2022: 13-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -194, Underdog Moneyline: +162)

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