Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:13 a.m.

The San Diego Padres will face the Colorado Rockies in MLB action on Wednesday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Rockies Game Info

• San Diego Padres (16-7) vs. Colorado Rockies (9-15)
• Date: Wednesday, April 22, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-166) | COL: (+140)
• Spread: SD: -1.5 (-113) | COL: +1.5 (-106)
• Total: 12 -- Over: (-110) | Under: (-110)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 1-1, 4.58 ERA vs Tomoyuki Sugano (Rockies) - 1-1, 3.92 ERA

This contest's pitching matchup is set, as the Padres will send Walker Buehler (1-1) to the mound, while Tomoyuki Sugano (1-1) will answer the bell for the Rockies. Buehler and his team have covered in each of the four games he's started with a spread this season. Buehler's team is 1-1 this season when he starts and they're favored on the moneyline. The Rockies have a 2-2-0 record against the spread in Sugano's starts. The Rockies have been the moneyline underdog in four of Sugano's starts this season, and they went 2-2 in those games.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.6%)

Padres vs Rockies Moneyline

• San Diego is a -166 favorite on the moneyline, while Colorado is a +140 underdog at home.

Padres vs Rockies Spread

• The Padres are at the Rockies and are favored by 1.5 runs (-113 to cover) on the runline. Colorado is -106 to cover.

Padres vs Rockies Over/Under

• An over/under of 12 has been set for Padres-Rockies on April 22, with the over being -110 and the under -110.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have been chosen as favorites in 10 games this year and have walked away with the win eight times (80%) in those games.
• San Diego has not lost in four games this year when favored by -166 or better on the moneyline.
• The Padres and their opponents have gone over in nine of their 23 games with a total set by sportsbooks this season.
• The Padres have posted a record of 15-8-0 against the spread this season.
• The Rockies have won 37.5% of the games this season they were the moneyline underdog (9-15).
• Colorado is 6-14 (winning just 30% of its games) when playing as a moneyline underdog of +140 or longer.
• In the 24 games bookmakers have set an over/under for the Rockies, they have combined with opponents to go over the total nine times (9-15-0).
• The Rockies have a 15-9-0 record ATS this season (covering 62.5% of the time).

Padres Player Leaders

• Xander Bogaerts leads San Diego with a slugging percentage of .398, fueled by five extra-base hits. He has a .265 batting average and an on-base percentage of .337.
• Among all qualifying hitters in the majors, his batting average ranks 61st, his on-base percentage ranks 79th, and he is 86th in slugging.
• Bogaerts has hit safely in three games in a row. In his last five games he is batting .188 with three walks and an RBI.
• Ramon Laureano has 21 hits, which ranks first among San Diego batters this season. He's batting .259 with nine extra-base hits. He's also slugging .481 with an on-base percentage of .315.
• Among qualified hitters, he ranks 70th in batting average, 114th in on-base percentage and 43rd in slugging percentage.
• Jackson Merrill has 19 hits this season and has a slash line of .213/.271/.382.
• Fernando Tatis Jr. leads the Padres with an OPS of .660. He has a slash line of .265/.347/.313 this season.
• Tatis heads into this game on a three-game hitting streak. During his last five outings he is hitting .353 with three walks and four RBIs.

Rockies Player Leaders

• Mickey Moniak is hitting .271 with three doubles, six home runs and three walks. He's slugging .627 with an on-base percentage of .302.
• Moniak hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is batting .286 with three doubles, three home runs, two walks and seven RBIs.
• Troy Johnston paces his team with 21 hits and a .360 OBP, with a team-best .478 slugging percentage. He has a batting average of .304.
• He is currently 18th in batting average, 50th in on-base percentage and 44th in slugging percentage among all qualifying batters.
• T.J. Rumfield has a double, a triple, three home runs and seven walks while hitting .244.
• Hunter Goodman is hitting .241 with four doubles, five home runs and six walks.

Padres vs Rockies Head to Head

• 4/21/2026: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/9/2026: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/14/2025: 9-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 9/13/2025: 11-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/12/2025: 4-2 COL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)

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