Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 8:11 p.m.

On Wednesday in MLB, the San Diego Padres are playing the Colorado Rockies.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Rockies Game Info

• San Diego Padres (16-7) vs. Colorado Rockies (9-15)
• Date: Wednesday, April 22, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | COL: (+132)
• Spread: SD: -1.5 (-106) | COL: +1.5 (-113)
• Total: 12 -- Over: (-120) | Under: (-102)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 1-1, 4.58 ERA vs Tomoyuki Sugano (Rockies) - 1-1, 3.92 ERA

This contest's pitching matchup is set, as the Padres will send Walker Buehler (1-1) to the mound, while Tomoyuki Sugano (1-1) will get the nod for the Rockies. Buehler and his team have covered in each of the four games he's started with a spread this season. Buehler's team is 1-1 this season when he starts and they're favored on the moneyline. The Rockies have a 2-2-0 ATS record in Sugano's four starts that had a set spread. The Rockies are 2-2 in Sugano's four starts this season that they were the moneyline underdog.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.6%)

Padres vs Rockies Moneyline

• San Diego is a -156 favorite on the moneyline, while Colorado is a +132 underdog at home.

Padres vs Rockies Spread

• The Padres are at the Rockies and are favored by 1.5 runs on the spread. The Padres are -106 to cover the runline, with the Rockies being -113.

Padres vs Rockies Over/Under

• Padres versus Rockies, on April 22, has an over/under of 12, with the over being -120 and the under -102.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have been favorites in 10 games this season and have come away with the win eight times (80%) in those contests.
• San Diego has not lost in four games when named as a moneyline favorite of -156 or better.
• Contests with the Padres have gone over the total set by bookmakers in nine of 23 chances this season.
• The Padres have posted a record of 15-8-0 against the spread this season.
• The Rockies have gone 9-15 in games they were listed as the moneyline underdog (winning 37.5% of those games).
• Colorado has an 8-14 record (winning only 36.4% of its games) when it has played as a moneyline underdog of +132 or longer.
• In the 24 games bookmakers have set an over/under for the Rockies, they have combined with opponents to go over the total nine times (9-15-0).
• The Rockies have a 15-9-0 record ATS this season (covering 62.5% of the time).

Padres Player Leaders

• Xander Bogaerts leads San Diego with a slugging percentage of .398, fueled by five extra-base hits. He has a .265 batting average and an on-base percentage of .337.
• Among qualified hitters in MLB, he ranks 61st in batting average, 78th in on-base percentage, and 84th in slugging.
• Bogaerts hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .188 with three walks and an RBI.
• Ramon Laureano leads San Diego with 21 hits. He is batting .259 this season and has nine extra-base hits. He's also slugging .481 with an on-base percentage of .315.
• He ranks 71st in batting average, 114th in on-base percentage and 41st in slugging among qualifying hitters.
• Jackson Merrill has 19 hits this season and has a slash line of .213/.271/.382.
• Fernando Tatis Jr. leads the Padres with an OPS of .660. He has a slash line of .265/.347/.313 this season.
• Tatis brings a three-game hitting streak into this game. In his last five games he is batting .353 with three walks and four RBIs.

Rockies Player Leaders

• Mickey Moniak is hitting .271 with three doubles, six home runs and three walks. He's slugging .627 with an on-base percentage of .302.
• Moniak hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is hitting .286 with three doubles, three home runs, two walks and seven RBIs.
• T.J. Rumfield is batting .244 with a double, a triple, three home runs and seven walks. He's slugging .390 with an on-base percentage of .300.
• Including all qualified hitters, he is 89th in batting average, 131st in on-base percentage and 91st in slugging percentage.
• Troy Johnston has put up a team-high OBP (.360) and slugging percentage (.478), while pacing the Rockies in hits (21).
• Hunter Goodman has four doubles, five home runs and six walks while batting .241.

Padres vs Rockies Head to Head

• 4/21/2026: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/9/2026: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/14/2025: 9-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 9/13/2025: 11-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/12/2025: 4-2 COL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!