Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 8:11 p.m.

The MLB's Tuesday slate includes the San Diego Padres taking on the Colorado Rockies.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Rockies Game Info

• San Diego Padres (15-7) vs. Colorado Rockies (9-14)
• Date: Tuesday, April 21, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | COL: (+124)
• Spread: SD: -1.5 (+100) | COL: +1.5 (-120)
• Total: 11 -- Over: (-115) | Under: (-105)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-0, 2.49 ERA vs Jimmy Herget (Rockies) - 0-1, 1.64 ERA

The Padres will give the ball to Randy Vasquez (1-0, 2.49 ERA), who is eyeing win No. 2 on the season, and the Rockies will turn to Jimmy Herget (0-1, 1.64 ERA). Vasquez and his team have covered in each of his four starts with a spread this season. Vasquez's team won his only start as a favorite this season. Herget has started just one game with a set spread, which the Rockies failed to cover. The Rockies were the underdog on the moneyline for one Herget start this season -- they lost.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (68.4%)

Padres vs Rockies Moneyline

• Looking at the moneyline for Rockies-Padres, Colorado is the underdog at +124, and San Diego is -146 playing on the road.

Padres vs Rockies Spread

• The Padres are at the Rockies and are favored by 1.5 runs on the spread. The Padres are +100 to cover the runline, with the Rockies being -120.

Padres vs Rockies Over/Under

• The over/under for Padres-Rockies on April 21 is 11. The over is -115, and the under is -105.

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Padres vs Rockies Betting Trends

• The Padres have been chosen as favorites in nine games this year and have walked away with the win seven times (77.8%) in those games.
• San Diego has been a -146 moneyline favorite on six occasions this season and won every time.
• The Padres and their opponents have gone over the total this season in nine of their 22 opportunities.
• The Padres have posted a record of 15-7-0 against the spread this season.
• The Rockies have won nine of the 23 games they were the moneyline underdog this season (39.1%).
• When it has played as a moneyline underdog with odds of +124 or longer, Colorado has gone 8-14 (36.4%).
• The Rockies have combined with opponents to go over the total nine times this season for a 9-14-0 record against the over/under.
• The Rockies have put together a 14-9-0 record ATS this season.

Padres Player Leaders

• Xander Bogaerts has an OPS of .746, fueled by an OBP of .341 to go with a slugging percentage of .405. He has a .266 batting average, as well.
• He is 64th in batting average, 76th in on-base percentage, and 80th in slugging among qualified hitters in baseball.
• Bogaerts has picked up at least one hit in two games in a row. In his last five games he is batting .250 with a home run, three walks and three RBIs.
• Ramon Laureano leads San Diego with 21 hits and a team-best slugging percentage of .506. He's batting .273 with an on-base percentage of .329.
• Among qualifying batters, he ranks 54th in batting average, 93rd in on-base percentage and 33rd in slugging percentage.
• Jackson Merrill has 19 hits this season and has a slash line of .221/.272/.395.
• Fernando Tatis Jr. is batting .253 with a .340 OBP and 12 RBI for San Diego this season.
• Tatis has safely hit in two straight games. In his last five games he is hitting .308 with three walks and five RBIs.

Rockies Player Leaders

• Mickey Moniak is batting .273 with three doubles, six home runs and three walks. He's slugging .655 with an on-base percentage of .305.
• Moniak brings a five-game hitting streak into this game. In his last five games he is batting .333 with three doubles, a home run, two walks and three RBIs.
• T.J. Rumfield has a double, a triple, three home runs and seven walks while hitting .253. He's slugging .405 with an on-base percentage of .310.
• Including all qualified hitters, his batting average puts him 81st, his on-base percentage ranks 118th, and he is 80th in slugging.
• Troy Johnston has accumulated a team-best OBP (.375) and slugging percentage (.500), and paces the Rockies in hits (21).
• Hunter Goodman is hitting .241 with four doubles, five home runs and six walks.

Padres vs Rockies Head to Head

• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/9/2026: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/14/2025: 9-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 9/13/2025: 11-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/12/2025: 4-2 COL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/6/2025: 10-8 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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