Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for April 26

Odds updated as of 12:14 a.m.

In MLB action on Sunday, the San Diego Padres face the Arizona Diamondbacks.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Diamondbacks Game Info

• San Diego Padres (18-8) vs. Arizona Diamondbacks (14-12)
• Date: Sunday, April 26, 2026
• Time: 4:05 p.m. ET
• Venue: Estadio Alfredo Harp Helu -- Mexico City, Mexico
• Coverage: Dbacks.TV and Padres.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-124) | ARI: (+106)
• Spread: SD: -1.5 (+106) | ARI: +1.5 (-128)
• Total: 15.5 -- Over: (-110) | Under: (-110)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 3-1, 2.28 ERA vs Ryne Nelson (Diamondbacks) - 1-2, 6.97 ERA

The Padres will give the nod to Michael King (3-1) against the Diamondbacks and Ryne Nelson (1-2). King and his team are 2-3-0 ATS this season when he starts. King's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Diamondbacks are 2-3-0 ATS in Nelson's five starts that had a set spread. The Diamondbacks have been the moneyline underdog in five of Nelson's starts this season, and they went 1-4 in those games.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (52.8%)

Padres vs Diamondbacks Moneyline

• The moneyline numbers for Padres vs. Diamondbacks reveal San Diego as the favorite (-124) and Arizona as the underdog (+106) despite being the home team.

Padres vs Diamondbacks Spread

• The Padres are 1.5-run road favorites on the runline against the Diamondbacks. The Padres are +106 to cover, and the Diamondbacks are -128.

Padres vs Diamondbacks Over/Under

• The Padres-Diamondbacks game on April 26 has been given an over/under of 15.5 runs. The over is set at -110 and the under at -110.

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Padres vs Diamondbacks Betting Trends

• The Padres have been chosen as favorites in 12 games this year and have walked away with the win nine times (75%) in those games.
• This season San Diego has been victorious eight times in 10 chances when named as a favorite of at least -124 on the moneyline.
• The Padres' games have gone over the total in 10 of their 26 opportunities.
• In 26 games with a line this season, the Padres have a mark of 17-9-0 against the spread.
• The Diamondbacks have won 43.8% of the games this season they were the underdog on the moneyline (7-9).
• In games it has played as a moneyline underdog with odds of +106 or longer, Arizona has a 7-6 record (winning 53.8% of its games).
• The Diamondbacks have played in 26 games with a set over/under, and have combined with opponents to go over the total 15 times (15-10-1).
• The Diamondbacks have covered 69.2% of their games this season, going 18-8-0 ATS.

Padres Player Leaders

• Xander Bogaerts leads San Diego with an OBP of .362, plus a team-best slugging percentage of .430. He's batting .280 on the season.
• He is 41st in batting average, 42nd in on-base percentage, and 68th in slugging among all qualified hitters in the majors.
• Ramon Laureano leads San Diego in total hits (24) this season while batting .255 with 10 extra-base hits. He's slugging .468 with an on-base percentage of .314.
• His batting average is 74th among qualified players, his on-base percentage 119th, and his slugging percentage 47th.
• Jackson Merrill has collected 20 base hits, an OBP of .278 and a slugging percentage of .357 this season.
• Manny Machado is batting .198 with a .324 OBP and 11 RBI for San Diego this season.
• Machado heads into this game on a three-game hitting streak. During his last five outings he is hitting .200 with a walk and an RBI.

Diamondbacks Player Leaders

• Corbin Carroll has accumulated a team-best OBP (.400), while pacing the Diamondbacks in hits (24). He's batting .289 and slugging.
• Including all the qualifying players in the majors, he ranks 30th in batting average, 15th in on-base percentage and 11th in slugging percentage.
• Ildemaro Vargas is slugging .649 to lead his team. He has a batting average of .351 with an on-base percentage of .368.
• Geraldo Perdomo has three doubles, three triples, a home run and 14 walks while hitting .250.
• Ketel Marte has three doubles, four home runs and nine walks while batting .240.

Padres vs Diamondbacks Head to Head

• 4/25/2026: 6-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 16, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/28/2025: 12-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/26/2025: 7-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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